Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Marcel J. J. Blommers"'
Autor:
Youssef Hamway, Kaspar Zimmermann, Marcel J. J. Blommers, Mariana V. Sousa, Cécile Häberli, Shashank Kulkarni, Susanna Skalicky, Matthias Hackl, Marjo Götte, Jennifer Keiser, Clarissa Prazeres da Costa, Thomas Spangenberg, Kamal Azzaoui
Publikováno v:
ACS Infectious Diseases. 8:2028-2034
Autor:
Harald Schwalbe, Peter Schmieder, Marco Fragai, Nils Trieloff, Rebecca Del Conte, Hartmut Oschkinat, Edgar Specker, Lucia Banci, Kamal Azzaoui, Vladimir V. Ivanov, Till Kuehn, Sridhar Sreeramulu, Christian Richter, Marcel J. J. Blommers, Marc Nazaré
Publikováno v:
Journal of Biomolecular NMR
Journal of Biomolecular Nmr
Journal of Biomolecular Nmr
Fragment-based screening has evolved as a remarkable approach within the drug discovery process both in the industry and academia. Fragment screening has become a more structure-based approach to inhibitor development, but also towards development of
Autor:
Tatjana Schamber, Kamal Azzaoui, Nusrat S. Qureshi, Boris Fürtig, Oliver Binas, Jason N Martins, Marcel J. J. Blommers, Daniel Hymon, Alix Tröster, Jasleen Kaur Bains, Christian Richter, Harald Schwalbe, Elke Stirnal, Andreas Oxenfarth, Julia Wirmer-Bartoschek, Hannes Berg, Anna Wacker, Robbin Schnieders, Tom Landgraf, Vanessa de Jesus, Santosh Lakshmi Gande, Sridhar Sreeramulu, Thomas Biedenbänder, Maria Alexandra Wirtz Martin, Albrecht Eduard Völklein, Anna Niesteruk
Publikováno v:
ChemBioChem
Chembiochem
Chembiochem
We report here on the nuclear magnetic resonance (NMR) 19 F screening of 14 RNA targets with different secondary and tertiary structure to systematically assess druggability of RNAs. Our RNA targets include representative bacterial riboswitches that
Publikováno v:
Journal of chemical information and modeling. 59(5)
The Argonaute-2 protein is part of the RNA-induced silencing complex (RISC) and anchors the guide strand of the small interfering RNA (siRNA). The 3'-end of the RNA contains two unpaired nucleotides (3'-overhang) that interact with the PAZ (PIWI/Argo
Publikováno v:
CHIMIA, Vol 74, Iss 10, Pp 798-802 (2020)
Systemic lupus erythematosus (SLE) is an autoimmune disease that often leads to functional disorder in multiple organs, most often with symptoms related to skin lesions, cardiovascular disease and kidney damage. Although significant efforts have been
Autor:
Marcel J J, Blommers, Wolfgang, Jahnke
Publikováno v:
Angewandte Chemie (International ed. in English). 37(4)
Help in determining biomolecular structure by NMR spectroscopy is found in a new method recently proposed by Reif, Hennig, and Griesinger, which enables the direct measurement of angles between bond vectors (see picture; X, Y=
Autor:
Xiaolu Zhang, Jeffery A. Porter, Atwood K. Cheung, Vic E. Myer, Mark C. Fishman, Caroline Gubser Keller, Rajeev Sivasankaran, John A. Tallarico, Marc Hild, Sven Schuierer, Michael McLellan, Frada Berenshteyn, William F. Dietrich, Cecile Blaustein, Youngah Shin, Lei Shu, Michael Salcius, Monish Jain, Mailin Van Hoosear, Donovan N. Chin, Arnaud Lacoste, Martin Beibel, James Palacino, Nicole A. Renaud, Leo Murphy, Marcel J. J. Blommers, Lawrence G. Hamann, Caroline Bullock, Xiaoying Shi, Lin Deng, Jason R. Thomas, Daniel Curtis, Thomas M. Smith, Susanne E. Swalley, Gregory A. Michaud, Cheng Song, Brian Tseng, Guglielmo Roma, Natalie Dales, Rebecca Servais
Publikováno v:
Nature Chemical Biology. 11:511-517
Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric mortality. A duplicate copy (SMN2) is inefficiently spliced, producing a tru
The beta-chain of human interleukin 12 (IL-12) contains at position 319-322, the sequence Trp-x-x-Trp. In human RNase 2 this is the recognition motif for a new, recently discovered posttranslational modification, i.e., the C-glycosidic attachment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24f8c51bcf800d1adb3c07661cd7ce3
http://doc.rero.ch/record/304956/files/9-5-435.pdf
http://doc.rero.ch/record/304956/files/9-5-435.pdf
Autor:
Frank Petersen, Ashutosh Kumar, Siva Jeganathan, Marc Baldus, Eva-Maria Mandelkow, Henrike Heise, Esther K. Schmitt, Teresa Carlomagno, Marcel J. J. Blommers, Christian Griesinger, Philipp Krastel
Publikováno v:
Angewandte Chemie. 122:7666-7669
Solid evidence: Induction of the polymerization of β-tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid-state NMR spectroscopy of patupilone bound to micr
Autor:
Jens Meiler, Karel Kubíček, Víctor M. Sánchez-Pedregal, Teresa Carlomagno, Christian Griesinger, Marcel Reese, Marcel J. J. Blommers
Publikováno v:
Angewandte Chemie International Edition. 46:1864-1868
Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure-activity relationship data for epothilones with both native and mutant tubulins, an