Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Marcel Hollenstein"'
Autor:
Maëva Pichon, Marcel Hollenstein
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Oligonucleotides are advancing as essential materials for the development of new therapeutics, artificial genes, or in storage of information applications. Hitherto, our capacity to write (i.e., synthesize) oligonucleotides is not as efficie
Externí odkaz:
https://doaj.org/article/8768d30ea5484a64ad2092f57bf6481a
Autor:
Mikaël Boullé, Alix Boucharlat, Ambre Leleu, Céline Banal, Aurélie Coussement, Marcel Hollenstein, Frank Yates, Nathalie Lefort, Fabrice Agou
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103350- (2024)
Human induced Pluripotent Stem Cells (hiPSCs) represent an invaluable source of primary cells to investigate development, establish cell and disease models, provide material for regenerative medicine and allow more physiological high-content screenin
Externí odkaz:
https://doaj.org/article/670abe90fddf4373896cf392088b9aec
Autor:
Marie Flamme, Steven Hanlon, Irene Marzuoli, Kurt Püntener, Filippo Sladojevich, Marcel Hollenstein
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-12 (2022)
Controlled enzymatic DNA synthesis represents an alternative synthetic methodology that circumvents the limitations of traditional soild-phase synthesis. Here, the authors explore the use of 3’-phosphate as a transient protecting group for the cont
Externí odkaz:
https://doaj.org/article/f8dffe1d56d24661a896a0d6fbbd77d3
Autor:
Nazarii Sabat, Dace Katkevica, Karlis Pajuste, Marie Flamme, Andreas Stämpfli, Martins Katkevics, Steven Hanlon, Serena Bisagni, Kurt Püntener, Filippo Sladojevich, Marcel Hollenstein
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Enzymatic, de novo XNA synthesis represents an alternative method for the production of long oligonucleotides containing chemical modifications at distinct locations. While such an approach is currently developed for DNA, controlled enzymatic synthes
Externí odkaz:
https://doaj.org/article/9b2b3d084b7e48e9b531540bf44bec58
Autor:
Chiara Figazzolo, Frédéric Bonhomme, Saidbakhrom Saidjalolov, Mélanie Ethève-Quelquejeu, Marcel Hollenstein
Publikováno v:
Molecules, Vol 27, Iss 24, p 8927 (2022)
Many potent antibiotics fail to treat bacterial infections due to emergence of drug-resistant strains. This surge of antimicrobial resistance (AMR) calls in for the development of alternative strategies and methods for the development of drugs with r
Externí odkaz:
https://doaj.org/article/645459c8315742fcb7153dae70022f8e
Autor:
Mikaël Boullé, Laurianne Davignon, Keïs Nabhane Saïd Halidi, Salomé Guez, Emilie Giraud, Marcel Hollenstein, Fabrice Agou
Publikováno v:
Cells, Vol 11, Iss 23, p 3862 (2022)
CEP55 is a central regulator of late cytokinesis and is overexpressed in numerous cancers. Its post-translationally controlled recruitment to the midbody is crucial to the structural coordination of the abscission sequence. Our recent evidence that C
Externí odkaz:
https://doaj.org/article/a4a2442309c844fd9690b9d3c13d989b
Autor:
Marcel Hollenstein
Publikováno v:
Molecules, Vol 20, Iss 11, Pp 20777-20804 (2015)
Deoxyribozymes or DNAzymes are single-stranded catalytic DNA molecules that are obtained by combinatorial in vitro selection methods. Initially conceived to function as gene silencing agents, the scope of DNAzymes has rapidly expanded into diverse fi
Externí odkaz:
https://doaj.org/article/ae0b0a2a4b6b4a25b76e2f45428f2799
Autor:
Stella Diafa, Marcel Hollenstein
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 16643-16671 (2015)
The enzymatic co-polymerization of modified nucleoside triphosphates (dN*TPs and N*TPs) is a versatile method for the expansion and exploration of expanded chemical space in SELEX and related combinatorial methods of in vitro selection. This strategy
Externí odkaz:
https://doaj.org/article/d1e0d93436fe48d7b45ac40f739700bf
Autor:
Marcel Hollenstein
Publikováno v:
Molecules, Vol 17, Iss 11, Pp 13569-13591 (2012)
Nucleoside triphosphates are moldable entities that can easily be functionalized at various locations. The enzymatic polymerization of these modified triphosphate analogues represents a versatile platform for the facile and mild generation of (highly
Externí odkaz:
https://doaj.org/article/d93a776134e8443d97d0726f2ed4247b
Autor:
Kyoung-Ran Kim, Pascal Röthlisberger, Seong Jae Kang, Kihwan Nam, Sangyoup Lee, Marcel Hollenstein, Dae-Ro Ahn
Publikováno v:
Molecules, Vol 23, Iss 7, p 1833 (2018)
Rolling circle amplification (RCA) is a robust way to generate DNA constructs, which are promising materials for biomedical applications including drug delivery because of their high biocompatibility. To be employed as a drug delivery platform, howev
Externí odkaz:
https://doaj.org/article/9920c02b5f894fa782d89c762aef39a3