Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Marcel Hibert"'
Autor:
Michael C. Johnson, Jonathan A. Zweig, Yangmiao Zhang, Louis Nunez, Olga P. Ryabinina, Marcel Hibert, Andrey E. Ryabinin
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract There is much interest in targeting the activity in the oxytocin system to regulate social bonding. However, studies with exogenous administration of oxytocin face the caveats of its low stability, poor brain permeability and insufficient re
Externí odkaz:
https://doaj.org/article/d8e68e12c8d74b4db84c6210d29cefe0
Autor:
Florent Péron, Stéphanie Riché, Brigitte Lesur, Marcel Hibert, Philippe Breton, Jean-Marie Fourquez, Nicolas Girard, Dominique Bonnet
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 15182-15192 (2018)
Externí odkaz:
https://doaj.org/article/c4d6b21dab3c4184bf1a90c890f0c662
Autor:
Maria Zeniou, Marie Fève, Samir Mameri, Jihu Dong, Christophe Salomé, Wanyin Chen, Elias A El-Habr, Fanny Bousson, Mohamadou Sy, Julie Obszynski, Alexandre Boh, Pascal Villa, Suzana Assad Kahn, Bruno Didier, Dominique Bagnard, Marie-Pierre Junier, Hervé Chneiweiss, Jacques Haiech, Marcel Hibert, Marie-Claude Kilhoffer
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134793 (2015)
Cancer stem-like cells reside in hypoxic and slightly acidic tumor niches. Such microenvironments favor more aggressive undifferentiated phenotypes and a slow growing "quiescent state" which preserves them from chemotherapeutic agents that essentiall
Externí odkaz:
https://doaj.org/article/156722edabe1482bb542a356e8277dd4
Autor:
Michael Zimmermann, Cédric Atmanene, Qingyan Xu, Laetitia Fouillen, Alain Van Dorsselaer, Dominique Bonnet, Claire Marsol, Marcel Hibert, Sarah Sanglier-Cianferani, Claire Pigault, Laurie K McNamara, D Martin Watterson, Jacques Haiech, Marie-Claude Kilhoffer
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14120 (2010)
Death-Associated Protein Kinase (DAPK) is a member of the Ca2+/calmodulin regulated serine/threonine protein kinases. Its biological function has been associated with induced cell death, and in vivo use of selective small molecule inhibitors of DAPK
Externí odkaz:
https://doaj.org/article/d9359a116e634e4bb98d0150476fb795
Autor:
Sheena Potretzke, Yangmiao Zhang, Ju Li, Kristopher M. Fecteau, David W. Erikson, Marcel Hibert, Andrey E. Ryabinin
Publikováno v:
Neuropsychopharmacology. 48:920-928
Targeting the oxytocin (OXT) peptide system has emerged as a promising new approach for the treatment of alcohol use disorder (AUD). However, further advancements in this development depend on properly modeling various complex social aspects of AUD a
Autor:
Marcel Hibert
Publikováno v:
Biologie Aujourd’hui. 216:125-130
L’ocytocine est une neurohormone connue à l’origine pour son rôle dans les contractions de l’utérus au moment de l’accouchement et les contractions des glandes mammaires pour permettre l’éjection du lait lors de la tétée. Depuis les 2
Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking
Publikováno v:
Journal of medicinal chemistry. 65(20)
We here describe a computational approach (POEM: Pocket Oriented Elaboration of Molecules) to drive the generation of target-focused libraries while taking advantage of all publicly available structural information on protein-ligand complexes. A coll
Autor:
Jean-Marie Fourquez, Brigitte Lesur, Nicolas Girard, Stéphanie Riché, Florent Péron, Marcel Hibert, Dominique Bonnet, Philippe Breton
Publikováno v:
ACS Omega
ACS Omega, ACS Publications, 2018, 3 (11), pp.15182-15192. ⟨10.1021/acsomega.8b01752⟩
ACS Omega, 2018, 3 (11), pp.15182-15192. ⟨10.1021/acsomega.8b01752⟩
ACS Omega, Vol 3, Iss 11, Pp 15182-15192 (2018)
ACS Omega, ACS Publications, 2018, 3 (11), pp.15182-15192. ⟨10.1021/acsomega.8b01752⟩
ACS Omega, 2018, 3 (11), pp.15182-15192. ⟨10.1021/acsomega.8b01752⟩
ACS Omega, Vol 3, Iss 11, Pp 15182-15192 (2018)
Herein, we report a convenient synthesis of unprecedented aza-diketopiperazines (aza-DKPs). The strategy is based on selective diversification of bicyclic aza-DKP scaffolds by click reaction, N-acylation, and/or N-alkylation. These scaffolds containi
Autor:
Claire Marsol, Christel Valencia, Thierry Durroux, Marcel Hibert, Dominique Bonnet, Julie Le Merrer, Pascal Villa, Marie-Céline Frantz, Jérôme A.J. Becker, Stéphanie Loison, Elsa Pflimlin, Bernard Mouillac, Lucie P. Pellissier, Jorge Gandía
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/ACS.JMEDCHEM.8B00697⟩
Journal of Medicinal Chemistry, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/ACS.JMEDCHEM.8B00697⟩
Journal of Medicinal Chemistry, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
International audience; Oxytocin (OT) and its receptor (OT-R) are implicated in the etiology of autism spectrum disorders (ASD), and OT-R is a potential target for therapeutic intervention. Very few nonpeptide oxytocin agonists have currently been re
Autor:
Eléonore Réal, Perrine Inquimbert, Hervé Chneiweiss, Laëtitia Chézeau, Marie-Pierre Junier, Jihu Dong, Pascal Villa, Wanyin Chen, Songlin Niu, Sylvain Hugel, Jacques Haiech, Maria Zeniou, Marie-Claude Kilhoffer, Leonel Nguekeu Zebaze, Frédéric Bihel, Emmanuel Boutant, Marcel Hibert
Publikováno v:
Oncotarget. 9:27197-27219
Glioblastoma is a highly heterogeneous brain tumor. The presence of cancer cells with stem-like and tumor initiation/propagation properties contributes to poor prognosis. Glioblastoma cancer stem-like cells (GSC) reside in hypoxic and acidic niches f