Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marcel Gubler"'
Autor:
Sabine Sewing, Marcel Gubler, Régine Gérard, Blandine Avignon, Yasmin Mueller, Annamaria Braendli-Baiocco, Marielle Odin, Annie Moisan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 67-79 (2019)
Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has
Externí odkaz:
https://doaj.org/article/2372d539f88947098a3a24ddd5408f46
Autor:
Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing, Régine Gérard, Blandine Avignon, Sylwia Huber, Fethallah Benmansour, Xing Chen, Roberto Villaseñor, Annamaria Braendli-Baiocco, Matthias Festag, Andreas Maunz, Thomas Singer, Franz Schuler, Adrian B. Roth
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 89-105 (2017)
Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in improving AON affinity and stability by incorporation of high affinity nucleotides, such as locked
Externí odkaz:
https://doaj.org/article/6a19a17eb817471d91d25a02041685db
Autor:
Marcel Gubler, Kamille Dumong Erichsen, Adrian Roth, Régine Gérard, Fethallah Benmansour, Xing Chen, Jitao David Zhang, Sylwia Huber, Matthias Festag, Yann Tessier, Roberto Villaseñor, Sabine Sewing, Blandine Avignon, Thomas Singer, Andreas Maunz, Franz Schuler, Annie Moisan, Annamaria Braendli-Baiocco
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss, Pp 89-105 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in improving AON affinity and stability by incorporation of high affinity nucleotides, such as locked
Autor:
Tim Tetaz, Marcel Gubler, Armin Ruf, Dragana Cubrilovic, Wolfgang Haap, Konstantin Barylyuk, Jörg Benz, Martin Badertscher, Renato Zenobi, Catherine Joseph
Publikováno v:
ACS chemical biology
This study highlights the benefits of nano electrospray ionization mass spectrometry (nanoESI-MS) as a fast and label-free method not only for determination of dissociation constants (KD) of a cooperatively regulated enzyme but also to better underst
Autor:
Stephan Kirchner, Paul Hebeisen, Eric A. Kitas, Effie Tozzo, Bernd Kuhn, Marcel Gubler, Armin Ruf, Hans Peter Wessel, Ulrich Zutter, Wolfgang Haap, Catherine Joseph, Peter Mohr, Rubén Alvarez-Sánchez, Jörg Benz, Agnès Bénardeau, Brigitte Schott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3237-3242
A novel sulfonylureido pyridine series exemplified by compound 19 yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the all
Autor:
Axel Paehler, Hans Peter Wessel, Armin Ruf, Jörg Benz, Catherine Joseph, Marcel Gubler, Eric A. Kitas, Brigitte Schott, Bernd Kuhn, Peter Mohr, Effie Tozzo, Agnès Bénardeau, Paul Hebeisen, Walter Huber, Ruben Alvarez Sanchez, Wolfgang Haap
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:594-599
Sulfonylureido thiazoles were identified from a HTS campaign and optimized through a combination of structure-activity studies, X-ray crystallography and molecular modeling to yield potent inhibitors of fructose-1,6-bisphosphatase. Compound 12 showed
Autor:
Brigitte Schott, Bernd Kuhn, Eric A. Kitas, Paul Hebeisen, Kohler Philipp Christoph, Marcel Gubler, Armin Ruf, Jörg Benz, Walter Huber, Catherine Joseph
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4708-4712
Human fructose-1,6-bisphosphatase (FBPase, EC 3.1.3.11) is a key gluconeogenic enzyme, responsible for the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate, and thus presents an opportunity for the development of novel therapeutics foc
Autor:
Abdul G. Dulloo, Sandro Rusconi, Marcel Gubler, Giovanni Solinas, Serge Summermatter, Josiane Seydoux, Jean-Pierre Montani, Davide Mainieri, Matthias P. Wymann, Luciano Pirola
Publikováno v:
FEBS Letters. 577:539-544
We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP-activ
Autor:
Krzysztof Wrzesinski, Maria Bobadilla, Stephen J. Fey, Tobias Bergauer, Line Visby Hansen, Signe Marie Andersen, Kira Joensen, Jacques Mizrahi, Marcel Gubler, Ove B. Schaffalitzky de Muckadell, Jacob Bastholm Olesen, Christina Møller Andreasen, Kelan Zhang, Maria Chiara Magnone, Marianne Ehrhorn Kruse
Publikováno v:
Wrzesinski, K, Magnone, M C, Hansen, L V, Ehrhorn Kruse, M, Bergauer, T, Bobadilla, M, Gubler, M, Mizrahi, J, Zhang, K, Andreasen, C M, Joensen, K, Andersen, S M, Olesen, J B, Schaffalitzky de Muckadell, O B & Fey, S J 2013, ' HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation ', Toxicology Research, vol. 2, no. 3, pp. 163-172 . https://doi.org/10.1039/c3tx20086h
Primary human hepatocytes are widely used as an in vitro system for the assessment of drug metabolism and toxicity. Nevertheless a cell system with higher stability of physiological functions is required for the investigation of drugs’ mode of acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4053ffb15294539a9dc44f05c77ffa7f
https://findresearcher.sdu.dk:8443/ws/files/118365785/c3tx20086h_3.pdf
https://findresearcher.sdu.dk:8443/ws/files/118365785/c3tx20086h_3.pdf
Autor:
Davide Mainieri, Jean-Pierre Montani, Marcel Gubler, Giovanni Solinas, Serge Summermatter, Abdul G. Dulloo, Steven R. Smith, Josiane Seydoux
The mechanisms by which CRH and related peptides (i.e. the CRH/urocortin system) exert their control over thermogenesis and weight regulation have until now focused only upon their effects on brain centers controlling sympathetic outflow. Using a met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ed6a2100ab79fad1fa487b835d754f
http://doc.rero.ch/record/5827/files/dulloo_crh.pdf
http://doc.rero.ch/record/5827/files/dulloo_crh.pdf