Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marcel Grunert"'
Autor:
Emilie Auxerre-Plantié, Tanja Nielsen, Marcel Grunert, Olga Olejniczak, Andreas Perrot, Cemil Özcelik, Dennis Harries, Faramarz Matinmehr, Cristobal Dos Remedios, Christian Mühlfeld, Theresia Kraft, Rolf Bodmer, Georg Vogler, Silke R. Sperling
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 12 (2020)
The causal genetic underpinnings of congenital heart diseases, which are often complex and multigenic, are still far from understood. Moreover, there are also predominantly monogenic heart defects, such as cardiomyopathies, with known disease genes f
Externí odkaz:
https://doaj.org/article/3ad5653fc6794cb9940a877a8adecd22
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 4, p 55 (2020)
Congenital heart defects (CHDs) are the most common birth defect in human with an incidence of almost 1% of all live births. Most cases have a multifactorial origin with both genetics and the environment playing a role in its development and progress
Externí odkaz:
https://doaj.org/article/b6c47bd4008142038e5b1d4a46caa9f6
Autor:
Huanhuan Cui, Vikas Bansal, Marcel Grunert, Barbora Malecova, Alessandra Dall'Agnese, Lucia Latella, Sole Gatto, Tammy Ryan, Kerstin Schulz, Wei Chen, Cornelia Dorn, Pier Lorenzo Puri, Silke R Sperling
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179464 (2017)
Post-translational modifications of histones play a key role in the regulation of gene expression during development and differentiation. Numerous studies have shown the dynamics of combinatorial regulation by transcription factors and histone modifi
Externí odkaz:
https://doaj.org/article/f32d63eabccb4d259cc60d9c53e249b9
Autor:
Vikas Bansal, Cornelia Dorn, Marcel Grunert, Sabine Klaassen, Roland Hetzer, Felix Berger, Silke R Sperling
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85375 (2014)
Copy number variations (CNVs) are one of the main sources of variability in the human genome. Many CNVs are associated with various diseases including cardiovascular disease. In addition to hybridization-based methods, next-generation sequencing (NGS
Externí odkaz:
https://doaj.org/article/8507afd5487b4e10898e10604e2e3f00
Autor:
Jenny Schlesinger, Markus Schueler, Marcel Grunert, Jenny J Fischer, Qin Zhang, Tammo Krueger, Martin Lange, Martje Tönjes, Ilona Dunkel, Silke R Sperling
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001313 (2011)
The transcriptome, as the pool of all transcribed elements in a given cell, is regulated by the interaction between different molecular levels, involving epigenetic, transcriptional, and post-transcriptional mechanisms. However, many previous studies
Externí odkaz:
https://doaj.org/article/72cd5d310afe4fc48a30165758214c33
Autor:
Marcel Grunert, Georg Vogler, Christian Mühlfeld, Tanja Nielsen, Andreas Perrot, Rolf Bodmer, Emilie Auxerre-Plantié, Cemil Özcelik, Faramarz Matinmehr, Cristobal G. dos Remedios, Theresia Kraft, Dennis Harries, Olga Olejniczak, Silke Sperling
The causal genetic underpinnings of congenital heart diseases, which are often complex and with multigenic background, are still far from understood. Moreover, there are also predominantly monogenic heart defects, such as cardiomyopathies, with known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c785b5c6aef9e656b2b17e1be78824
https://doi.org/10.1101/2020.08.18.255760
https://doi.org/10.1101/2020.08.18.255760
Autor:
Marcel Grunert, Sandra Appelt, Sophia Schönhals, Kerstin Mika, Huanhuan Cui, Ashley Cooper, Lukas Cyganek, Kaomei Guan, Silke R. Sperling
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Patient-specific induced pluripotent stem cells (ps-iPSCs) and their differentiated cell types are a powerful model system to gain insight into mechanisms driving early developmental and disease-associated regulatory networks. In this study, we use p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cade378397d1dfcf6ac1b7e3a41295
http://edoc.mdc-berlin.de/19672/1/19672oa.pdf
http://edoc.mdc-berlin.de/19672/1/19672oa.pdf
Autor:
Emilie, Auxerre-Plantié, Tanja, Nielsen, Marcel, Grunert, Olga, Olejniczak, Andreas, Perrot, Cemil, Özcelik, Dennis, Harries, Faramarz, Matinmehr, Cristobal, Dos Remedios, Christian, Mühlfeld, Theresia, Kraft, Rolf, Bodmer, Georg, Vogler, Silke R, Sperling
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The causal genetic underpinnings of congenital heart diseases, which are often complex and multigenic, are still far from understood. Moreover, there are also predominantly monogenic heart defects, such as cardiomyopathies, with known disease genes f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc249f3bb6d50a9f199efe2245a8f042
https://pubmed.ncbi.nlm.nih.gov/33033063
https://pubmed.ncbi.nlm.nih.gov/33033063
Publikováno v:
Oxford Medicine
A large quantity of molecular information on heart development, function, and disease has been generated over recent decades. However, most recent studies have been dominated by reductionistic approaches, and thus many aspects remain unclear, particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eaa16c5adfa3a40f70cc5f3903d08d4
https://doi.org/10.1093/med/9780198757269.003.0033
https://doi.org/10.1093/med/9780198757269.003.0033
Autor:
Tammy Ryan, Barbora Malecova, Alessandra Dall’Agnese, Lucia Latella, Marcel Grunert, Wei Chen, Vikas Bansal, Sole Gatto, Pier Lorenzo Puri, Kerstin Schulz, Huanhuan Cui, Cornelia Dorn, Silke Sperling
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179464 (2017)
PLoS ONE
PLoS ONE
Post-translational modifications of histones play a key role in the regulation of gene expression during development and differentiation. Numerous studies have shown the dynamics of combinatorial regulation by transcription factors and histone modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2525076111de0f91f26e47876366f55f
http://europepmc.org/articles/PMC5469484?pdf=render
http://europepmc.org/articles/PMC5469484?pdf=render