Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marcel G M Wolfs"'
Autor:
Jingyuan Fu, Marcel G M Wolfs, Patrick Deelen, Harm-Jan Westra, Rudolf S N Fehrmann, Gerard J Te Meerman, Wim A Buurman, Sander S M Rensen, Harry J M Groen, Rinse K Weersma, Leonard H van den Berg, Jan Veldink, Roel A Ophoff, Harold Snieder, David van Heel, Ritsert C Jansen, Marten H Hofker, Cisca Wijmenga, Lude Franke
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002431 (2012)
It is known that genetic variants can affect gene expression, but it is not yet completely clear through what mechanisms genetic variation mediate this expression. We therefore compared the cis-effect of single nucleotide polymorphisms (SNPs) on gene
Externí odkaz:
https://doaj.org/article/c2e46c2fe1164b25a0671e51aed9423d
Autor:
Rudolf S N Fehrmann, Ritsert C Jansen, Jan H Veldink, Harm-Jan Westra, Danny Arends, Marc Jan Bonder, Jingyuan Fu, Patrick Deelen, Harry J M Groen, Asia Smolonska, Rinse K Weersma, Robert M W Hofstra, Wim A Buurman, Sander Rensen, Marcel G M Wolfs, Mathieu Platteel, Alexandra Zhernakova, Clara C Elbers, Eleanora M Festen, Gosia Trynka, Marten H Hofker, Christiaan G J Saris, Roel A Ophoff, Leonard H van den Berg, David A van Heel, Cisca Wijmenga, Gerard J Te Meerman, Lude Franke
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002197 (2011)
For many complex traits, genetic variants have been found associated. However, it is still mostly unclear through which downstream mechanism these variants cause these phenotypes. Knowledge of these intermediate steps is crucial to understand pathoge
Externí odkaz:
https://doaj.org/article/9c6dcd0644c6483f840acfa04a2fe276
Autor:
Bruce H. R. Wolffenbuttel, Ghazaleh Hajmousa, Ewa Szalowska, K Fluiter, Marcel G. M. Wolfs, Dicky Struik, J. V. van Vliet-Ostaptchouk, T. P. van der Meer, Johan W. Jonker, Ronit Shiri-Sverdlov, U A Unmehopa, Roel J. Vonk, Vera J. M. Nies, Dick F. Swaab, Farhad Rezaee, W.A. Buurman, Jan Greve, Sander S. Rensen
Publikováno v:
International journal of obesity (2005), 42, 376-383. Nature Publishing Group
International Journal of Obesity, 42(3), 376-383
International Journal of Obesity, 42(3), 376-383. Nature Publishing Group
International Journal of Obesity, 42, 376-383. Nature Publishing Group
International Journal of Obesity, 42(3), 376-383
International Journal of Obesity, 42(3), 376-383. Nature Publishing Group
International Journal of Obesity, 42, 376-383. Nature Publishing Group
BACKGROUND/OBJECTIVES: Mutations in the Tubby gene (TUB) cause late-onset obesity and insulin resistance in mice and syndromic obesity in humans. Although TUB gene function has not yet been fully elucidated, studies in rodents indicate that TUB is in
Autor:
Froukje J. Verdam, Jingyuan Fu, Lude Franke, M. H. Hofker, Cisca Wijmenga, Nanda Gruben, Sander S. Rensen, W.A. Buurman, Ann Driessen, Marcel G. M. Wolfs, Ronit Shiri-Sverdlov, T.W. van Haeften, Debby P.Y. Koonen, Jan Greve, Ludger Scheja
Publikováno v:
Nutrition & Diabetes
Nutrition & Diabetes, 5:e146. Nature Publishing Group
Nutrition & diabetes
Nutrition & Diabetes, 5:146. Nature Publishing Group
Nutrition & Diabetes, 5:e146. Nature Publishing Group
Nutrition & diabetes
Nutrition & Diabetes, 5:146. Nature Publishing Group
OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated disease, and in obesity adipokines are believed to be involved in the development of NAFLD. However, it is still not clear whether adipokines in the liver and/or adipose t
Autor:
Cisca Wijmenga, Gabriël J.E. Rinkel, Marcel G. M. Wolfs, Song Tang, Ruben van 't Slot, Ynte M. Ruigrok
Publikováno v:
Human Molecular Genetics. 15:3361-3368
Intracranial aneurysm is probably a complex disease with both genetic and non-genetic or environmental risk factors contributing to the etiology of the disease. A disruption of the extracellular matrix (ECM) of the arterial wall is a likely factor in
Autor:
Lude Franke, Mart Kals, Marc Jan Bonder, Kaie Lokk, Jan Greve, Marten H. Hofker, Cisca Wijmenga, Alexandra Zhernakova, Patrick Deelen, Jana V. van Vliet-Ostaptchouk, Wim A. Buurman, Magnus Ingelman-Sundberg, Riin Tamm, Isabel Barragan, Jingyuan Fu, Marcel G. M. Wolfs, Sander S. Rensen, Maxim Ivanov, Lili Milani, Silva Kasela
Publikováno v:
BMC Genomics, 15(1):860. BioMed Central Ltd
BMC Genomics
BMC Genomics, 15(860). BioMed Central Ltd.
BMC Genomics
BMC Genomics, 15(860). BioMed Central Ltd.
Background The liver plays a central role in the maintenance of homeostasis and health in general. However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less i
Autor:
Meena Kumari, Claire E. Hastie, Jonathan Stephens, Patricia B. Munroe, Christopher P. Nelson, John M. C. Connell, Martin D. Tobin, Hani Neuvrith, Jean Tichet, Paul Burton, Gudrun Veldre, Daniele Cusi, Anna Levinsson, Paul Elliott, Elin Org, Erika Salvi, Tina Shah, Nabila Devos, Harm-Jan Westra, Juan-Pablo Casas, Olle Melander, Jan A. Staessen, Nilesh J. Samani, Jackie A. Cooper, Peter S. Braund, Neil R Poulter, Alive V. Stanton, Abiodun Onipinla, Marcel G. M. Wolfs, Steve E. Humphries, Philippa J. Talmud, Rebecca Hardy, Fotios Drenos, Maris Laan, Mark J. Caulfield, Richard Dobson, Willem H. Ouwehand, Yun Zhang, Li Chen, SG Wannamethee, Sue Shaw-Hawkins, Christopher Newton-Cheh, Eoin O'Brien, Simon A. McG. Thom, Maria Grazia Franzosi, Charles A. Mein, Mika Kivimäki, Tom R. Gaunt, Jennifer G. Sambrook, Andrea Stucchi, Annika Rosengren, Sonia Shah, Thomas Hedner, George A. Wells, Dag S. Thelle, Debbie A Lawlor, Pierre-François Plouin, Fredrik Nyberg, Richard W Morris, Ian N M Day, Vesela Gateva, Lude Franke, Peter S. Sever, Morris J. Brown, Margus Putku, Sandosh Padmanabhan, John F. Peden, Pim van der Harst, Jutta Palmen, Ioanna Tzoulaki, Alexandre F.R. Stewart, Andrew Wong, Peeter Juhanson, Marciej Tomaszewski, Alison H. Goodall, Martin Farrall, Wai K. Lee, Nicola Glorioso, Hugh Watkins, Xavier Jeunemaitre, Anders Hamsten, Robert Clarke, Anna F. Dominiczak, Mark Lathrop, Stephen Newhouse, Margus Viigimaa, George Davey Smith, Robert Roberts, John C. Whittaker, Michael V. Holmes, Toby Johnson, F. Gerald R. Fowkes, Aroon D. Hingorani, Udo Seedorf, Siim Sõber, Denis C. Shields, Diana Kuh, Chris Wallace, Philip Howard, Peter H. Whincup, Gonçalo R. Abecasis, Anuj Goel, Christian Delles, Björn Wahlstrand
Publikováno v:
American Journal of Human Genetics, 89(6), 688-700. CELL PRESS
American journal of human genetics, vol. 89, no. 6, pp. 688-700
The American Journal of Human Genetics; Vol 89
Johnson, T, Gaunt, T R, Newhouse, S J, Padmanabhan, S, Tomaszewski, M, Kumari, M, Morris, R W, Tzoulaki, I, O'Brien, E T, Poulter, N R, Sever, P, Shields, D C, Thom, S, Wannamethee, S G, Whincup, P H, Brown, M J, Connell, J M, Dobson, R J, Howard, P J, Mein, C A, Onipinla, A, Shaw-Hawkins, S, Zhang, Y, Smith, G D, Day, I N M, Lawlor, D A, Goodall, A H, Fowkes, F G, Abecasis, G R, Elliott, P, Gateva, V, Braund, P S, Burton, P R, Nelson, C P, Tobin, M D, van der Harst, P, Glorioso, N, Neuvrith, H, Salvi, E, Staessen, J A, Stucchi, A, Devos, N, Jeunemaitre, X, Plouin, P-F, Tichet, J, Juhanson, P, Org, E, Putku, M, Sober, S, Veldre, G 2011, ' Blood Pressure Loci Identified with a Gene-Centric Array ', American Journal of Human Genetics, vol. 89, no. 6, pp. 688-700 . https://doi.org/10.1016/j.ajhg.2011.10.013
American journal of human genetics, vol. 89, no. 6, pp. 688-700
The American Journal of Human Genetics; Vol 89
Johnson, T, Gaunt, T R, Newhouse, S J, Padmanabhan, S, Tomaszewski, M, Kumari, M, Morris, R W, Tzoulaki, I, O'Brien, E T, Poulter, N R, Sever, P, Shields, D C, Thom, S, Wannamethee, S G, Whincup, P H, Brown, M J, Connell, J M, Dobson, R J, Howard, P J, Mein, C A, Onipinla, A, Shaw-Hawkins, S, Zhang, Y, Smith, G D, Day, I N M, Lawlor, D A, Goodall, A H, Fowkes, F G, Abecasis, G R, Elliott, P, Gateva, V, Braund, P S, Burton, P R, Nelson, C P, Tobin, M D, van der Harst, P, Glorioso, N, Neuvrith, H, Salvi, E, Staessen, J A, Stucchi, A, Devos, N, Jeunemaitre, X, Plouin, P-F, Tichet, J, Juhanson, P, Org, E, Putku, M, Sober, S, Veldre, G 2011, ' Blood Pressure Loci Identified with a Gene-Centric Array ', American Journal of Human Genetics, vol. 89, no. 6, pp. 688-700 . https://doi.org/10.1016/j.ajhg.2011.10.013
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a055dcda09bbb36bdfdb963307732402
https://lirias.kuleuven.be/handle/123456789/341626
https://lirias.kuleuven.be/handle/123456789/341626
Autor:
Sander S. Rensen, Marcel G. M. Wolfs, Marcel Bruinenberg, Bahram Sanjabi, Wim A. Buurman, Cisca Wijmenga, Jan Greve, Elinda J. Bruin-Van Dijk, Froukje J. Verdam, Timon W. van Haeften, Marten H. Hofker, Lude Franke
Publikováno v:
BMC Medical Genomics, 3(1):34. BioMed Central Ltd
BMC Medical Genomics
BMC Medical Genomics, 3:34. BioMed Central Ltd.
BMC Medical Genomics, Vol 3, Iss 1, p 34 (2010)
BMC Medical Genomics
BMC Medical Genomics, 3:34. BioMed Central Ltd.
BMC Medical Genomics, Vol 3, Iss 1, p 34 (2010)
Background Excessive accumulation of body fat, in particular in the visceral fat depot, is a major risk factor to develop a variety of diseases such as type 2 diabetes. The mechanisms underlying the increased risk of obese individuals to develop co-m
Publikováno v:
Current Genomics, 10(2), 110-118. BENTHAM SCIENCE PUBL LTD
Current Genomics
Current Genomics
Type 2 diabetes is a disorder of dysregulated glucose homeostasis. Normal glucose homeostasis is a complex process involving several interacting mechanisms, such as insulin secretion, insulin sensitivity, glucose production, and glucose uptake. The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22dd2e1fb58d48c32d13eb9357df8a6
https://research.rug.nl/en/publications/c57e7677-440d-422c-aeb7-4d6ee0a9e5f6
https://research.rug.nl/en/publications/c57e7677-440d-422c-aeb7-4d6ee0a9e5f6
Autor:
Niels J. Kloosterhuis, Marten H. Hofker, Debby P.Y. Koonen, Marcel G. M. Wolfs, Henk van der Molen, Marijke Schreurs, Nanda Gruben, Fareeba Sheedfar, Anouk Funke
Publikováno v:
Nederlands Tijdschrift voor Diabetologie. 9:98-98
Features of the metabolic syndrome, such as dyslipidaemia and inflammation, are risk factors contributing to insulin resistance and type 2 diabetes. However, little is known regarding the contribution of these features in the development of insulin r