Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Marcel Frans Leopold De Bruyn"'
Autor:
Miroslav Cik, John R. Atack, Paula te Riele, Marcel Frans Leopold De Bruyn, Ria Wouters, Gregor James Macdonald, Jef Vermeire, Herman M. R. Hendrickx, Anton Megens, Luc Peeters, Hilde Lavreysen, Xavier Langlois
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:91-105
All marketed antipsychotics act by blocking dopamine D(2) receptors. Fast dissociation from D(2) receptors may be one of the elements contributing to the lower incidence of extrapyramidal symptoms (EPS) exhibited by newer antipsychotics. Therefore, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48a38efd535318d7970257f097b7ea8
https://doi.org/10.1124/jpet.111.190702
https://doi.org/10.1124/jpet.111.190702
Autor:
Marcel Frans Leopold De Bruyn, W. J. Janssens, Wim Gaston Verschueren, Josée E. Leysen, Jan Verrelst, Guy Van Lommen, Marc Francis Josephine Schroven
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2649-2654
The synthesis and SAR of a series of non-indole 5HT1D agonists is described. The most interesting molecule of this series is compound 13, alniditan. It is active as a constrictor of the saphenous vein of the dog and of the pig basilar artery with ED5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d024e8d6f0f545203b92aba50ede6927
https://doi.org/10.1016/0960-894x(95)00473-7
https://doi.org/10.1016/0960-894x(95)00473-7
Autor:
Marcel Janssen, Jan M. Van Nueten, Marcel Frans Leopold De Bruyn, Georges Henri Paul Van Daele, Francois Maria Sommen, Josée E. Leysen, Jan A.J. Schuurkes, Carlos J. E. Niemegeers
Publikováno v:
Drug Development Research. 8:225-232
A novel synthon, 3-hydroxy-4,4-dimethoxy-N-phenylmethylpiperidine, is reported on for the preparation of 3-oxygenated-4-substituted piperidines. Different synthetic approaches are described for the synthesis of cis and trans 3-hydroxy- or 3-methoxy-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e2a8b5791b5238eb900ed974863467
https://doi.org/10.1002/ddr.430080127
https://doi.org/10.1002/ddr.430080127