Synthesis and anti-HIV-1 integrase activity of modified dinucleotides

Autor: Julien Weiss, Ulysse Asseline, Victoria Roig, Gladys Mbemba, Marcel Chassignol, Jean-François Mouscadet, Hervé Meudal, Yves Aubert

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (12), pp.5029-5044. ⟨10.1016/j.ejmech.2009.09.007⟩

International audience; The synthesis of a series of thirty-eight new modified dinucleotides and dinucleotide conjugate analogues of d-(5')ApC(3') is described. The inhibitory activity of these compounds toward HIV-1 integrase was examined in enzymat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b81009d8f77303de16c83119891bf3e
https://doi.org/10.1016/j.ejmech.2009.09.007

Solution structure of oligonucleotides covalently linked to a psoralen derivative

Autor: Marcel Chassignol, O. Bornet, Nguyen Thanh Thuong, Chantal Prévost, Françoise Vovelle, Gérard Lancelot

Publikováno v: Nucleic Acids Research. 23:788-795

Psoralen (pso) was attached via its C-5 position to the 5'-phosphate group of an oligodeoxynucleotide d(TAAGCCG) by a hexamethylene linker (m6). Complex formation between pso-m6-d(TAAGCCG) and the complementary strands d(CGGCTTA)[7-7mer] or d(CGGCTTA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a070152cd1055e1bc50ba80b986e90
https://doi.org/10.1093/nar/23.5.788

Photochemically and chemically activatable antisense oligonucleotides: comparison of their reactivities towards DNA and RNA targets

Autor: Gérard Godard, Isabelle Duroux, Nguyen Thanh Thuong, Ulysse Asseline, Claude Hélène, Tula Saison-Behmoaras, Marcel Chassignol, Jean-Christophe François

Publikováno v: Nucleic Acids Research. 22:4789-4795

Dodecadeoxyribonucleotides derivatized with 1,10-phenanthroline or psoralen were targeted to the point mutation (GU) in codon 12 of the Ha-ras mRNA. DNA and RNA fragments, 27 nucleotides in length, and containing the complementary sequence of the 12m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0facf3ac62408cd852e70f06768c685d
https://doi.org/10.1093/nar/22.22.4789

Solid-phase preparation of 5′,3′-heterobifunctional oligodeoxyribonucleotides using modified solid supports

Autor: Victoria Roig, Nguyen Thanh Thuong, Edwige Bonfils, Ulysse Asseline, Marcel Chassignol, Robin Kurfurst

Publikováno v: Tetrahedron. 48:1233-1254

The solid-phase preparation of oligodeoxyribonucleotides attached to intercalator or reactive groups through their 5′- and (or) 3′-ends is reported. These syntheses implicate the introduction of suitable masked functional groups at the 5′-end o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09d9eeefbc27442e08cb38073ad22f9f
https://doi.org/10.1016/s0040-4020(01)90786-0

Detection of terminal mismatches on DNA duplexes with fluorescent oligonucleotides

Autor: Marcel Chassignol, Yves Aubert, Victoria Roig, Ulysse Asseline

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2006, 4 (10), pp.1949-1957. ⟨10.1039/b602262f⟩

This paper describes the design of terminal-mismatch discriminating fluorescent oligonucleotides (TMDFOs). The method is based on the use of sets of oligo-2'-deoxyribonucleotide probes linked via their 5'-ends, and varying-sized flexible polymethylen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6023b0d46606fb3d11a9e9383603a0
https://hal.archives-ouvertes.fr/hal-00088833