Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Marcel B. Bally"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background The tumor microenvironment is profoundly heterogeneous particularly when comparing sites of metastases. Establishing the extent of this heterogeneity may provide guidance on how best to design lipid-based drug delivery systems to
Externí odkaz:
https://doaj.org/article/9192e449a6724fde9d21e119bf73a0bd
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2022 (2023)
Immunotherapy has changed the way many cancers are being treated. Researchers in the field of immunotherapy and tumor immunology are investigating similar questions: How can the positive benefits achieved with immunotherapies be enhanced? Can this be
Externí odkaz:
https://doaj.org/article/eb99b9eb33a04b9c94d4b5bce8a95c81
Autor:
Chandra Lebovitz, Nicole Wretham, Maryam Osooly, Katy Milne, Tia Dash, Shelby Thornton, Basile Tessier-Cloutier, Paalini Sathiyaseelan, Svetlana Bortnik, Nancy Erro Go, Elizabeth Halvorsen, Rachel A. Cederberg, Norman Chow, Nancy Dos Santos, Kevin L. Bennewith, Brad H. Nelson, Marcel B. Bally, Wan L. Lam, Sharon M. Gorski
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson’s disease, whereas our previous analyses of public cancer patient data revealed that decreased LRRK2 expression is as
Externí odkaz:
https://doaj.org/article/a628231eefc547ca89a67c8ce3fcdf31
Autor:
Courtney van Ballegooie, Nicole Wretham, Tanya Ren, Ioana-Mihaela Popescu, Donald T. Yapp, Marcel B. Bally
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1831 (2022)
Zein can be utilized to form nanoscale particles for drug delivery applications. Despite the ease of synthesis, these particles often aggregate when exposed to physiologically relevant conditions (e.g., pH and salt concentrations). This instability h
Externí odkaz:
https://doaj.org/article/eb980ce762fe45bcbfaa86d0e5df9aba
Autor:
Minghan Shi, Malathi Anantha, Mohamed Wehbe, Marcel B. Bally, David Fortin, Laurent-Olivier Roy, Gabriel Charest, Maxime Richer, Benoit Paquette, Léon Sanche
Publikováno v:
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is hampered by the blood–brain barrier which limits the entry into the brain of most drugs from the blood. To bypass this barrier, convection-enhanced de
Externí odkaz:
https://doaj.org/article/1d8455aa27bc4982b78c994a351776fe
Autor:
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J. O’Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia, Farhia Kabeer, Daniel Lai, Priscilla Soriano, Judit Banáth, Derek S. Chiu, Damian Yap, Daniel D. Le, Frank B. Ye, Anni Zhang, Kelsie Thu, John Soong, Shu-chuan Lin, Angela Hsin Chin Tsai, Tomo Osako, Teresa Algara, Darren N. Saunders, Jason Wong, Jian Xian, Marcel B. Bally, James D. Brenton, Grant W. Brown, Sohrab P. Shah, David Cescon, Tak W. Mak, Carlos Caldas, Peter C. Stirling, Phil Hieter, Shankar Balasubramanian, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be
Externí odkaz:
https://doaj.org/article/5b722e62084b4032919682ab16257e1a
Publikováno v:
Pharmaceutics, Vol 11, Iss 3, p 124 (2019)
Liposomes are considered one of the most successful drug delivery systems (DDS) given their established utility and success in the clinic. In the past 40–50 years, Canadian scientists have made ground-breaking discoveries, many of which were succes
Externí odkaz:
https://doaj.org/article/aebded877fac4bf786831e9953c71b06
Autor:
Roger Gilabert-Oriol, Gemma M. Ryan, Ada W.Y. Leung, Natalie S. Firmino, Kevin L. Bennewith, Marcel B. Bally
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 2922 (2018)
Tumours are complex systems of genetically diverse malignant cells that proliferate in the presence of a heterogeneous microenvironment consisting of host derived microvasculature, stromal, and immune cells. The components of the tumour microenvironm
Externí odkaz:
https://doaj.org/article/a6988743527c4cf992f962125ef3b6f5
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Fig.S1 shows that SCCOHT cells are sensitive to HDAC inhibition. Fig. S2 shows that SCCOHT cells are sensitive to HDAC inhibition or depletion. Fig.S3 shows that SMARCA4/A2 dual deficiency is not associated with hypersensitivity to HDAC inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2396ee9de14b76e5d7859ed9f267bb73
https://doi.org/10.1158/1535-7163.22510063.v1
https://doi.org/10.1158/1535-7163.22510063.v1
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but extremely lethal malignancy that mainly impacts young women. SCCOHT is characterized by a diploid genome with loss of SMARCA4 and lack of SMARCA2 expression, two mutually ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37952b52d6236e3e9efd5a279b26f72e
https://doi.org/10.1158/1535-7163.c.6539491
https://doi.org/10.1158/1535-7163.c.6539491