Výsledky vyhledávání - "Marcel Apparu"

Determination of the enantiomeric purity and the configuration of β-aminoalcohols using (R)-2-fluorophenylacetic acid (AFPA) and fluorine-19 NMR: application to β-blockers

Autor: Pierre-Marc Léo, Sylvain Hamman, Younes Ben Tiba, Christian Coulombeau, Marcel Apparu

Publikováno v: Tetrahedron: Asymmetry. 11:2885-2898

A method has been developed for determining the enantiomeric purity and the absolute configuration of β-aminoalcohols of type ArOCH2CH(OH)CH2NHR (R=iPr, tBu). To determine enantiomeric purity, the amine function was first protected by a benzyl group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::185260719675e88be916b39127755b52
https://doi.org/10.1016/s0957-4166(00)00254-8

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Synthesis of Potentially β-Blocking Practolol Derivatives: (E +Z)-3-[4-(3-Iodoprop-2-enyloxycarbonylamino)phenoxy]-1-(isopropylamino)propan-2-ol

Autor: Pierre-Marc Léo, Marcel Apparu, Younes Ben Tiba, Daniel Fagret

Publikováno v: European Journal of Organic Chemistry. 2000:1007-1012

The iodinatied carbamates 3 (E + Z), with potential β-blocking properties, were synthesized. The first route chosen, from 4-aminophenol and the chloroformate β7, had to be abandoned because of the formation of the oxazolidinone 10 during the epoxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0caa23d9e555da690f4e89aaf2f445bb
https://doi.org/10.1002/(sici)1099-0690(200003)2000:6<1007::aid-ejoc1007>3.0.co

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Synthesis of an iodine-labelled analogue of practolol: (S)-3-[4-(4-iodobut-3-encarboxamido)phenoxy]-1-isopropylaminopropan-2-ol (AMI-9S)

Autor: Younes Ben Tiba, Jean Paul Mathieu, Marcel Apparu, Pierre-Marc Léo, Laurent Mauclaire

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 42:1195-1202

AMI-9S was synthesized in the S configuration with an enantiomeric purity of over 97% and labelled with iodine-123 with a specific activity of 300 Ci/mmol. Enantiomeric purity was determined by 19 F NMR spectroscopy following derivatisation using (R)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c22d55d7571d5ad6cb9082f8bf50ec9f
https://doi.org/10.1002/(sici)1099-1344(199912)42:12<1195::aid-jlcr275>3.0.co

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ChemInform Abstract: Synthesis of Potentially β-Blocking Practolol Derivatives: (E + Z)-3- [4-(3-Iodoprop-2-enyloxycarbonylamino)phenoxy] -1-(isopropylamino)propan-2-ol

Autor: Pierre-Marc Léo, Younes Ben Tiba, Marcel Apparu, Daniel Fagret

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e7ded2502716e547b4dda98c69995d3
https://doi.org/10.1002/chin.200020084

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Metabolism of methyl-branched iodo palmitic acids in cultured hepatocytes

Autor: Jean Chambaz, Sabine Coornaert, Dominique Pepin, Michel Vidal, Marcel Apparu, Ginette Thomas, Gilbert Bereziat, Claude Loriette

Publikováno v: European Journal of Nuclear Medicine. 15:367-372

The metabolic fate of methyl-branched iodo fatty acids was studied in primary culture of rat hepatocytes. We compared 16-iodo-2-R,S-methyl palmitic acid (2-Me), which can be β oxidized, with 16-iodo-3-R,S-methyl palmitic acid (3-Me) which can be β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12e0154d12b384201598aa326b3ef83
https://doi.org/10.1007/bf00449226

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Stereoselective syntheses of O- and S-nitrophenyl glycosides. Part III. Syntheses in the α-D-galactopyranose and α-maltose series

Autor: Hugues Driguez, Marcel Apparu, Michèle Blanc-Muesser, Jacques Defaye

Publikováno v: Canadian Journal of Chemistry. 59:314-320

The action of p-nitrophenol on penta-O-acetyl-β-D-galactopyranose in dichloromethane, in the presence of stannic tetrachloride, gave p-nitrophenyl α-D-galactoside in fair yield. This technique failed when o-nitrophenol was used. Tetra-O-acetyl-β-D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e2e0f8aafe9c73432e18cefa30cc9d2
https://doi.org/10.1139/v81-049

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Cyclizations of .omega.-allenyl radicals

Autor: Marcel Apparu, Jack K. Crandall

Publikováno v: The Journal of Organic Chemistry. 49:2125-2130

Preparation d'halogenures allenyliques de structure (CH 3 ) 2 C=C=CH(CH 2 ) n X avec n=3 a 6 et etude de leurs reactions avec (n-C 4 H 9 ) 3 SnH pour donner les radicaux correspondants dont on examine les cyclisateurs. Influence de la longueur de la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::076e8cd1a36335de089db3d97c7590cb
https://doi.org/10.1021/jo00186a009

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