Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Marcel A. Vieira‐Lara"'
Autor:
Marcel A. Vieira-Lara, Marieke Warmerdam, Erik A. F. de Hulster, Marcel van den Broek, Jean-Marc Daran, Jack T. Pronk
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background Elimination of greenhouse gas emissions in industrial biotechnology requires replacement of carbohydrates by alternative carbon substrates, produced from CO2 and waste streams. Ethanol is already industrially produced from agricul
Externí odkaz:
https://doaj.org/article/7dc8c52f2b1a46d5ad2f5366feffcc01
Autor:
Christoff Odendaal, Emmalie A. Jager, Anne-Claire M. F. Martines, Marcel A. Vieira-Lara, Nicolette C. A. Huijkman, Ligia A. Kiyuna, Albert Gerding, Justina C. Wolters, Rebecca Heiner-Fokkema, Karen van Eunen, Terry G. J. Derks, Barbara M. Bakker
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Monogenetic inborn errors of metabolism cause a wide phenotypic heterogeneity that may even differ between family members carrying the same genetic variant. Computational modelling of metabolic networks may identify putative sourc
Externí odkaz:
https://doaj.org/article/c317aa533e824a27ae9be54b9fd0b3e9
Autor:
Marcel A. Vieira-Lara, Marleen B. Dommerholt, Wenxuan Zhang, Maaike Blankestijn, Justina C. Wolters, Fentaw Abegaz, Albert Gerding, Ydwine T. van der Veen, Rachel Thomas, Ronald P. van Os, Dirk-Jan Reijngoud, Johan W. Jonker, Janine K. Kruit, Barbara M. Bakker
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to
Externí odkaz:
https://doaj.org/article/a9716da0b74d420cb0e3c1ac024d69e9
Autor:
Fentaw Abegaz, Anne-Claire M F Martines, Marcel A Vieira-Lara, Melany Rios-Morales, Dirk-Jan Reijngoud, Ernst C Wit, Barbara M Bakker
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009259 (2021)
In this study we demonstrated through analytic considerations and numerical studies that the mitochondrial fatty-acid β-oxidation can exhibit bistable-hysteresis behavior. In an experimentally validated computational model we identified a specific r
Externí odkaz:
https://doaj.org/article/febc2d2c3e1e4399b08b47a1554814cc
CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases
Autor:
Roald A Lambrechts, Hein Schepers, Yi Yu, Marianne van der Zwaag, Kaija J Autio, Marcel A Vieira‐Lara, Barbara M Bakker, Marina A Tijssen, Susan J Hayflick, Nicola A Grzeschik, Ody CM Sibon
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-21 (2019)
Abstract PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defect
Externí odkaz:
https://doaj.org/article/d8554242c8ae4af6849ce730ce21786d
Autor:
Angela J. C. Tol, Kaja Hribar, Janine Kruit, Laura Bongiovanni, Marcel A. Vieira‐Lara, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Martijn Koehorst, Alain de Bruin, Barbara M. Bakker, Maaike H. Oosterveer, Eline M. van der Beek
Publikováno v:
Journal of Physiology, 601(10), 1761-1780. Wiley-Blackwell
Journal of Physiology, 601(10), 1761-1780. BLACKWELL PUBLISHING
Tol, A J C, Hribar, K, Kruit, J, Bongiovanni, L, Vieira-Lara, M A, Koster, M H, Kloosterhuis, N J, Havinga, R, Koehorst, M, de Bruin, A, Bakker, B M, Oosterveer, M H & van der Beek, E M 2023, ' Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model ', Journal of Physiology, vol. 601, no. 10, pp. 1761-1780 . https://doi.org/10.1113/JP284061
Journal of Physiology, 601(10), 1761-1780. BLACKWELL PUBLISHING
Tol, A J C, Hribar, K, Kruit, J, Bongiovanni, L, Vieira-Lara, M A, Koster, M H, Kloosterhuis, N J, Havinga, R, Koehorst, M, de Bruin, A, Bakker, B M, Oosterveer, M H & van der Beek, E M 2023, ' Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model ', Journal of Physiology, vol. 601, no. 10, pp. 1761-1780 . https://doi.org/10.1113/JP284061
Hyperglycaemia in pregnancy (HIP) is a pregnancy complication characterized by mild to moderate hyperglycaemia that negatively impacts short- and long-term health of mother and child. However, relationships between severity and timing of pregnancy hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1ee18648d2bd9e7fcfb867525e4768
https://dspace.library.uu.nl/handle/1874/429424
https://dspace.library.uu.nl/handle/1874/429424
Autor:
Marcel A. Vieira-Lara, Aaffien C. Reijne, Serj Koshian, Jolita Ciapaite, Fentaw Abegaz, Alzbeta Talarovicova, Theo H. van Dijk, Christian J. Versloot, Robert H.J. Bandsma, Justina C. Wolters, Albert K. Groen, Dirk-Jan Reijngoud, Gertjan van Dijk, Barbara M. Bakker
Publikováno v:
Diabetes.
Diet modulates the development of insulin resistance during aging. This includes tissue-specific alterations in insulin signaling and mitochondrial function, which ultimately affect glucose homeostasis. Exercise stimulates glucose clearance, mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7ef6e7f90c7261cfdd9855cbfba791
https://doi.org/10.2337/db220746
https://doi.org/10.2337/db220746
Autor:
Melany Rios-Morales, Marcel A. Vieira-Lara, Esther Homan, Miriam Langelaar-Makkinje, Albert Gerding, Zhuang Li, Nicolette Huijkman, Patrick C.N. Rensen, Justina C. Wolters, Dirk-Jan Reijngoud, Barbara M. Bakker
Publikováno v:
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(11):166476, 1-13. Elsevier
BBA-Molecular Basis of Disease, 1868(11). ELSEVIER
Biochimica et biophysica acta-Molecular basis of disease, 1868(11):166476. ELSEVIER SCIENCE BV
BBA-Molecular Basis of Disease, 1868(11). ELSEVIER
Biochimica et biophysica acta-Molecular basis of disease, 1868(11):166476. ELSEVIER SCIENCE BV
Skeletal muscle insulin resistance is a key pathophysiological process that precedes the development of type 2 diabetes. Whereas an overload of long-chain fatty acids can induce muscle insulin resistance, butyrate, a short -chain fatty acid (SCFA) pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0569eeb58690e331ebb92090b7586a
https://doi.org/10.1016/j.bbadis.2022.166476
https://doi.org/10.1016/j.bbadis.2022.166476
Autor:
Wenxuan Zhang, Rachel E. Thomas, Johan W. Jonker, Justina C. Wolters, Fentaw Abegaz, Janine K. Kruit, Ronald van Os, Marleen B Dommerholt, Barbara M. Bakker, Dirk-Jan Reijngoud, Maaike Blankestijn, Ydwine T. van der Veen, Marcel A. Vieira-Lara, Albert Gerding
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
BMC Biology, 19(1):154. BioMed Central Ltd.
BMC Biology
Vieira-Lara, M A, Dommerholt, M B, Zhang, W, Blankestijn, M, Wolters, J C, Abegaz, F, Gerding, A, van der Veen, Y T, Thomas, R, van Os, R P, Reijngoud, D J, Jonker, J W, Kruit, J K & Bakker, B M 2021, ' Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload ', BMC Biology, vol. 19, no. 1, 154 . https://doi.org/10.1186/s12915-021-01082-5
BMC Biology, 19(1):154. BioMed Central Ltd.
BMC Biology
Vieira-Lara, M A, Dommerholt, M B, Zhang, W, Blankestijn, M, Wolters, J C, Abegaz, F, Gerding, A, van der Veen, Y T, Thomas, R, van Os, R P, Reijngoud, D J, Jonker, J W, Kruit, J K & Bakker, B M 2021, ' Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload ', BMC Biology, vol. 19, no. 1, 154 . https://doi.org/10.1186/s12915-021-01082-5
Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to the emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5588b5270296379509163fcde869ad4
https://doaj.org/article/a9716da0b74d420cb0e3c1ac024d69e9
https://doaj.org/article/a9716da0b74d420cb0e3c1ac024d69e9
Autor:
Francine J. Boonekamp, Ewout Knibbe, Marcel A. Vieira-Lara, Melanie Wijsman, Marijke A.H. Luttik, Karen van Eunen, Maxime den Ridder, Reinier Bron, Ana Maria Almonacid Suarez, Patrick van Rijn, Justina C. Wolters, Martin Pabst, Jean-Marc Daran, Barbara M. Bakker, Pascale Daran-Lapujade
Publikováno v:
Cell Reports, 39(13):111010. Cell Press
Cell reports, 39(13):111010. CELL PRESS
Cell Reports, 39(13)
Cell reports, 39(13):111010. CELL PRESS
Cell Reports, 39(13)
Although transplantation of single genes in yeast plays a key role in elucidating gene functionality in metazoans, technical challenges hamper humanization of full pathways and processes. Empowered by advances in synthetic biology, this study demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6c37ae17abceac71463ceb4835f8a8
https://research.rug.nl/en/publications/fd1fea1c-43e9-4bf4-94c3-16cc1942d876
https://research.rug.nl/en/publications/fd1fea1c-43e9-4bf4-94c3-16cc1942d876