Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Marcel A. T. M. van Vugt"'
Autor:
Mengting Chen, Shibo Yu, Tineke van der Sluis, Mieke C. Zwager, Carolien P. Schröder, Bert van der Vegt, Marcel A. T. M. van Vugt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Genomic instability, as caused by oncogene-induced replication stress, can lead to the activation of inflammatory signaling, involving the cGAS-STING and JAK-STAT pathways. Inflammatory signaling has been associated with pro-tumorigenic feat
Externí odkaz:
https://doaj.org/article/d931abde027d426887bcda922a8f92ae
Autor:
Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K. de Kanter, Yannick P. Kok, Marieke Everts, H. Rudolf de Boer, Anastasia Audrey, Femke J. Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana C. J. Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M. Lansdorp, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sister chromatid exchanges (SCEs) are considered to be products of homologous recombination repair. The authors show that SCEs can arise independently of homologous recombination due to processing of replication intermediates during mitosis.
Externí odkaz:
https://doaj.org/article/6a7ed7595d2b4f12a042a1aaa930abc6
Autor:
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tripe-negative breast cancers poorly respond to immune checkpoint inhibition therapy, due to their immune-hostile tumour microenvironment. Authors here show that the oncogene MYC plays a pivotal role in suppressing anti-tumour immunity via directly r
Externí odkaz:
https://doaj.org/article/07f7321be51a4bf993332239abb08b2b
Autor:
Carlos G. Urzúa-Traslaviña, Vincent C. Leeuwenburgh, Arkajyoti Bhattacharya, Stefan Loipfinger, Marcel A. T. M. van Vugt, Elisabeth G. E. de Vries, Rudolf S. N. Fehrmann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Our understanding of the function of many transcripts is still incomplete, limiting the interpretability of transcriptomic data. Here the authors use consensus-independent component analysis, together with a guilt-by-association approach, to improve
Externí odkaz:
https://doaj.org/article/4a0123198db1432b8cd7b6fe248572ba
Autor:
Arkajyoti Bhattacharya, Rico D. Bense, Carlos G. Urzúa-Traslaviña, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Copy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extrac
Externí odkaz:
https://doaj.org/article/8a30eeb79fbb4839b329f70a9a9b4653
Autor:
Irena Bočkaj, Tosca E. I. Martini, Eduardo S. de Camargo Magalhães, Petra L. Bakker, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, Saskia L. Meuleman, Marin T. Mondria, Colin Stok, Yannick P. Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J. C. Broekhuis, Hilda van den Bos, Diana C. J. Spierings, Femke C. A. Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A. T. M. van Vugt, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Externí odkaz:
https://doaj.org/article/f0f9f42a292e496a8dbe120dc4b20697
Autor:
Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt, Arnab Ray Chaudhuri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Replication fork degradation can result in genome instability. Here authors reveal a role for Rif1 protein in protecting stalled replication forks from undergoing extensive, DNA2-dependent, degradation.
Externí odkaz:
https://doaj.org/article/cb070f743a7d4af79f8d12d89e2dfee4
Autor:
Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The loss of homologous recombination (HR) genes such as BRCA1 and BRCA2 is deleterious to the survival of normal cells, yet it is tolerated in cancer cells. Here the authors identify TNFα signaling as a determinant of viability in BRCA2- inactivated
Externí odkaz:
https://doaj.org/article/fe87c5673305416fa0c30e5631b208ed
Autor:
Saskia H. Hanemaaijer, Iris C. Kok, Rudolf S. N. Fehrmann, Bert van der Vegt, Jourik A. Gietema, Boudewijn E. C. Plaat, Marcel A. T. M. van Vugt, Marije R. Vergeer, C. René Leemans, Johannes A. Langendijk, Jens Voortman, Jan Buter, Sjoukje F. Oosting
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). However, around one-third of the patients cannot complete cisplatin beca
Externí odkaz:
https://doaj.org/article/41c85e17066d44cbaa8705b2b5208976
Autor:
Xiaojuan Zhao, Qingfeng Huang, Marjory Koller, Matthijs D. Linssen, Wouter T. R. Hooghiemstra, Steven J. de Jongh, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann, Enmin Li, Wouter B. Nagengast
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9270 (2021)
Dysplasia and intramucosal esophageal squamous cell carcinoma (ESCC) frequently go unnoticed with white-light endoscopy and, therefore, progress to invasive tumors. If suitable targets are available, fluorescence molecular endoscopy might be promisin
Externí odkaz:
https://doaj.org/article/91bcf381f8214a56bb52ea8da147dba8