Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Marcel A. G. van der Heyden"'
Autor:
Arne van Hunnik, Vladimír Sobota, Stef Zeemering, Dragan Opacic, Billy Scaf, Elisa D’Alessandro, Karel Oyaert, Marion Kuiper, Jonas G. Diness, Ulrik S. Sørensen, James T. Milnes, Marcel A. G. van der Heyden, Thomas Jespersen, Ulrich Schotten, Sander Verheule
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionThe mechanisms leading to the conversion of atrial fibrillation (AF) to sinus rhythm are poorly understood. This study describes the dynamic behavior of electrophysiological parameters and conduction patterns leading to spontaneous and ph
Externí odkaz:
https://doaj.org/article/e2c1854f221946c0bbb48d1da7b3f23f
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Introduction Medical undergraduate students receive limited education on scholarly publishing. However, publishing experiences during this phase are known to influence study and career paths. The medical bachelor Honours Program (HP) at Utre
Externí odkaz:
https://doaj.org/article/bec0302fb496499ab9a1d03e6b11567a
Autor:
Meye Bloothooft, Bente Verbruggen, Fitzwilliam Seibertz, Marcel A. G. van der Heyden, Niels Voigt, Teun P. de Boer
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Background: The rapid delayed rectifier potassium current (IKr) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias. However, accurately measuring this current can be challenging in human-induced pluripotent
Externí odkaz:
https://doaj.org/article/ae8be112595044e9923a346cd08dfa5f
Autor:
Vera Loen, Valerie Y. H. Van Weperen, Henriëtte D. M. Beekman, Joanne J. A. Van Bavel, Veronique M. F. Meijborg, Jeanne G. Van der Waal, Ruben Coronel, Marcel A. G. van der Heyden, Marc A. Vos
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: An electrical storm of Torsade de Pointes arrhythmias (TdP) can be reproducibly induced in the anesthetized chronic AV-block (CAVB) dog by infusion of the IKr-blocker dofetilide. Earlier studies showed that these arrhythmias 1) arise from
Externí odkaz:
https://doaj.org/article/f3c24e5d74424f14adc1e879c8499656
Autor:
Joanne J. A. van Bavel, Henriëtte D. M. Beekman, Agnieszka Smoczyńska, Marcel A. G. van der Heyden, Marc A. Vos
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1147 (2023)
Long QT syndrome type 1 with affected IKs is associated with a high risk for developing Torsade de Pointes (TdP) arrhythmias and eventually sudden cardiac death. Therefore, it is of high interest to explore drugs that target IKs as antiarrhythmics. W
Externí odkaz:
https://doaj.org/article/a63cf35a26a84fcbb4a9b9d52105b162
Autor:
Willem B. van Ham, Carlijn M. Cornelissen, Elizaveta Polyakova, Stephanie M. van der Voorn, Merel L. Ligtermoet, Jantine Monshouwer-Kloots, Marc A. Vos, Alexandre Bossu, Eva van Rooij, Marcel A. G. van der Heyden, Toon A. B. van Veen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5373 (2023)
Chronic kidney disease (CKD) is represented by a diminished filtration capacity of the kidneys. End-stage renal disease patients need dialysis treatment to remove waste and toxins from the circulation. However, endogenously produced uremic toxins (UT
Externí odkaz:
https://doaj.org/article/20fef1c6344a436d977429f3697e1f8d
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 404 (2023)
Expression and activity of inwardly rectifying potassium (KIR) channels within the heart are strictly regulated. KIR channels have an important role in shaping cardiac action potentials, having a limited conductance at depolarized potentials but cont
Externí odkaz:
https://doaj.org/article/b93a9920ec99443da6ee60688f9d6b84
Autor:
Marien J. C. Houtman, Theres Friesacher, Xingyu Chen, Eva-Maria Zangerl-Plessl, Marcel A. G. van der Heyden, Anna Stary-Weinzinger
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channe
Externí odkaz:
https://doaj.org/article/f720fead0f634b2e88a84576c7772e8d
Autor:
Encan Li, Vera Loen, Willem B. van Ham, Willy Kool, Marcel A. G. van der Heyden, Hiroki Takanari
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associate
Externí odkaz:
https://doaj.org/article/81971e8dc2804b3c81a691cb0e8da07f
Autor:
Valerie Y. H. van Weperen, Albert Dunnink, Alexandre Bossu, Jet D. M. Beekman, Veronique M. F. Meijborg, Jacques M. T. de Bakker, Ruben Coronel, Rosanne Varkevisser, Marcel A. G. van der Heyden, Marc A. Vos
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
IntroductionTorsade de pointes arrhythmias (TdP) in the chronic atrioventricular block (CAVB) dog model result from proarrhythmic factors, which trigger TdP and/or reinforce the arrhythmic substrate. This study investigated electrophysiological and a
Externí odkaz:
https://doaj.org/article/bdacac999a3a459cabb1649d2d8663b1