Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Marcel, Spaargaren"'
Autor:
Marthe Minderman, Hildo Lantermans, Carmen van der Zwaan, Arie J. Hoogendijk, Maartje van den Biggelaar, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a sign
Externí odkaz:
https://doaj.org/article/6567367aa7a8454c9dcdd166992c7d1a
Autor:
Marthe Minderman, Hildo C. Lantermans, Leonie J. Grüneberg, Saskia A. G. M. Cillessen, Richard J. Bende, Carel J. M. van Noesel, Marie José Kersten, Steven T. Pals, Marcel Spaargaren
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) is a protease and scaffold protein essential in propagating B-cell receptor (BCR) signaling to NF-κB. The deubiquitinating enzyme cylindromatosis (CYLD) is a recently discovered MA
Externí odkaz:
https://doaj.org/article/fa21a09a30c54eef9cb4825a4c293ec2
Autor:
Francesca Favaro, Demi Both, Ingrid A. M. Derks, Marcel Spaargaren, Cristina Muñoz-Pinedo, Eric Eldering
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-9 (2023)
Abstract Impairments in protein folding in the endoplasmic reticulum (ER) lead to a condition called ER stress, which can trigger apoptosis via the mitochondrial or the death receptor (extrinsic) pathway. There is controversy concerning involvement o
Externí odkaz:
https://doaj.org/article/e736815b837b4dfbba0af30109427fa2
Autor:
Martin F. M. de Rooij, Yvonne J. Thus, Nathalie Swier, Roderick L. Beijersbergen, Steven T. Pals, Marcel Spaargaren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Targeting integrin-mediated retention of malignant B cells in their protective microenvironment is an efficacious treatment for lymphoma and leukemia. Here, the authors present an unbiased loss-of-adhesion CRISPR screening method, identifying therape
Externí odkaz:
https://doaj.org/article/cf11224d056d474e933c4bbc83561105
Publikováno v:
Bio-Protocol, Vol 12, Iss 21 (2022)
Mature B-cell lymphomas are highly dependent upon the protective lymphoid organ microenvironment for their growth and survival. Targeting integrin-mediated homing and retention of the malignant B cells in the lymphoid organs, using the Bruton’s tyr
Externí odkaz:
https://doaj.org/article/97cb3683bdbf43d8b8fee200a6464e43
Autor:
Yvonne J. Thus, Martin F.M. de Rooij, Nathalie Swier, Roderick L. Beijersbergen, Jeroen E.J. Guikema, Marie-José Kersten, Eric Eldering, Steven T. Pals, Arnon P. Kater, Marcel Spaargaren
Publikováno v:
Haematologica, Vol 108, Iss 3 (2022)
BCL-2 family proteins are frequently aberrantly expressed in mantle cell lymphoma (MCL). Recently, the BCL-2-specific inhibitor venetoclax has been approved by the US Food and Drug Administration for chronic lymphocytic leukemia (CLL) and acute myelo
Externí odkaz:
https://doaj.org/article/44bb043e875f4dc08f5f043e88f5f9bc
Autor:
Zemin Ren, Hildo Lantermans, Annemieke Kuil, Willem Kraan, Fernando Arenzana-Seisdedos, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the chemokine CXCL12. CXCL12 regulates the homing to the BM niche by mediating th
Externí odkaz:
https://doaj.org/article/6fe651d0fce74e0a8a070beae4ab4b46
Autor:
Joost S. Vermaat, Sebastiaan F. Somers, Liesbeth C. de Wreede, Willem Kraan, Ruben A.L. de Groen, Anne M. R. Schrader, Emile D. Kerver, Cornelis G. Scheepstra, Henriëtte Berenschot, Wendy Deenik, Jurgen Wegman, Rianne Broers, Jan-Paul D. de Boer, Marcel Nijland, Tom van Wezel, Hendrik Veelken, Marcel Spaargaren, Arjen H. Cleven, Marie José Kersten, Steven T. Pals
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
The 2016 World Health Organization classification defines diffuse large B-cell lymphoma (DLBCL) subtypes based on Epstein-Barr virus (EBV) infection and oncogenic rearrangements of MYC/BCL2/BCL6 as drivers of lymphomagenesis. A subset of DLBCL, howev
Externí odkaz:
https://doaj.org/article/93ed3bb67e6c40e09d22bd1f61cc4a61
Autor:
Arnon P. Kater, Raluca Verona, Carel J.M. van Noesel, Eric Eldering, Homer C. Adams, Niels W.C.J. van de Donk, Christie P.M. Verkleij, Marcel Spaargaren, Koen de Heer, Lotte W.H.G. van Mil, An Ngo, Fleur S. Peters, Renate de Boer, Joanne M. Rietveld, Anne W.J. Martens
T-cell redirecting bispecific antibodies hold high promise for treatment of B-cell malignancies. B-cell maturation antigen (BCMA) exhibits high expression on normal and malignant mature B cells including plasma cells, which can be enhanced by inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49978e007ac5fb7c36005d8316e9123
https://doi.org/10.1158/2767-9764.c.6550694.v1
https://doi.org/10.1158/2767-9764.c.6550694.v1
Autor:
Arnon P. Kater, Raluca Verona, Carel J.M. van Noesel, Eric Eldering, Homer C. Adams, Niels W.C.J. van de Donk, Christie P.M. Verkleij, Marcel Spaargaren, Koen de Heer, Lotte W.H.G. van Mil, An Ngo, Fleur S. Peters, Renate de Boer, Joanne M. Rietveld, Anne W.J. Martens
Supplementary Table 1. CLL Patient characteristics. Supplementary Table 2. Healthy donor characteristics. Supplementary Table 3. MM patient characteristics. Supplementary Figure 1. γ-secretase inhibition increases BCMA levels but does not affect via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc8d79d31bbb2bed19c309d64008198
https://doi.org/10.1158/2767-9764.22544582
https://doi.org/10.1158/2767-9764.22544582