Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Marcel, Knossow"'
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101511- (2020)
Summary: Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as cell division, ciliogenesis, and intracellular trafficking. They assemble from αβ-tubulin heterodimers and disassemble in a process called dynamic in
Externí odkaz:
https://doaj.org/article/96120e22fab746a1ae4986209bdc9136
Publikováno v:
Protein Science. 24:1047-1056
Motile kinesins are motor proteins that move unidirectionally along microtubules as they hydrolyze ATP. They share a conserved motor domain (head) which harbors both the ATP- and microtubule-binding activities. The kinesin that has been studied most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b26ee4b2d5c3d634dae38155ca6c900
https://doi.org/10.1002/pro.2697
https://doi.org/10.1002/pro.2697
Autor:
Agata Nawrotek, Agathe Subtil, Beatriz G. Guimarães, Benoît Gigant, Christophe Velours, Marcel Knossow
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (36), pp.25199-25210. ⟨10.1074/jbc.M114.568436⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (36), pp.25199-25210. <10.1074/jbc.M114.568436>
Journal of Biological Chemistry, 2014, 289 (36), pp.25199-25210. ⟨10.1074/jbc.M114.568436⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (36), pp.25199-25210. ⟨10.1074/jbc.M114.568436⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (36), pp.25199-25210. <10.1074/jbc.M114.568436>
Journal of Biological Chemistry, 2014, 289 (36), pp.25199-25210. ⟨10.1074/jbc.M114.568436⟩
International audience; Although the actin network is commonly hijacked by pathogens, there are few reports of parasites targeting microtubules. The proposed member of the LcrE protein family from some Chlamydia species (e.g. pCopN from C. pneumoniae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b38ea22996992c18c09d502d0e72f7
https://doi.org/10.1074/jbc.m114.568436
https://doi.org/10.1074/jbc.m114.568436
Autor:
Ludovic Pecqueur, Magali Aumont-Nicaise, Andreas Plückthun, Shoeb Ahmad, Marcel Knossow, Birgit Dreier, Djemel Hamdane, Benoît Gigant
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, 〈10.1038/srep28922〉
'Scientific Reports ', vol: 6, pages: 28922-1-28922-14 (2016)
Scientific Reports, 2016, 6, ⟨10.1038/srep28922⟩
Scientific Reports, Nature Publishing Group, 2016, 6, ⟨10.1038/srep28922⟩
Scientific Reports, Nature Publishing Group, 2016, 6, 〈10.1038/srep28922〉
'Scientific Reports ', vol: 6, pages: 28922-1-28922-14 (2016)
Scientific Reports, 2016, 6, ⟨10.1038/srep28922⟩
Scientific Reports, Nature Publishing Group, 2016, 6, ⟨10.1038/srep28922⟩
Affinity maturation by random mutagenesis and selection is an established technique to make binding molecules more suitable for applications in biomedical research, diagnostics and therapy. Here we identified an unexpected novel mechanism of affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b3736213519d48e7afcde5663502c1
https://doi.org/10.1038/srep28922
https://doi.org/10.1038/srep28922
Autor:
Andreas Plückthun, Christian Duellberg, Ludovic Pecqueur, Birgit Dreier, Benoît Gigant, Qiyang Jiang, Thomas Surrey, Marcel Knossow, Chunguang Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (30), pp.12011-12016. ⟨10.1073/pnas.1204129109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (30), pp.12011-12016. ⟨10.1073/pnas.1204129109⟩
International audience; Microtubules are cytoskeleton filaments consisting of αβ-tubulin heterodimers. They switch between phases of growth and shrinkage. The underlying mechanism of this property, called dynamic instability, is not fully understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b8ee94617bef6c6c83437cffbcc9fb
https://doi.org/10.1073/pnas.1204129109
https://doi.org/10.1073/pnas.1204129109
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 68:927-934
Vinca-domain ligands are compounds that bind to tubulin at its inter-heterodimeric interface and favour heterogeneous protofilament-like assemblies, giving rise to helices and rings. This is the basis for their inhibition of microtubule assembly, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60050d779cb1a2c5a1cb50cac5f34dad
https://doi.org/10.1107/s0907444912017143
https://doi.org/10.1107/s0907444912017143
Autor:
Benoît Gigant, Fuming Zhang, Marcel Knossow, Ting Shen, Yuncong Lv, Chunguang Wang, Hureshitanmu Kuerban, Raphael Guerois, Weiyi Wang
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (30), pp.18721-31. 〈10.1074/jbc.M115.646919〉
Journal of Biological Chemistry, 2015, 290 (30), pp.18721-31. ⟨10.1074/jbc.M115.646919⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (30), pp.18721-31. ⟨10.1074/jbc.M115.646919⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (30), pp.18721-31. 〈10.1074/jbc.M115.646919〉
Journal of Biological Chemistry, 2015, 290 (30), pp.18721-31. ⟨10.1074/jbc.M115.646919⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (30), pp.18721-31. ⟨10.1074/jbc.M115.646919⟩
International audience; Kinesin-13 proteins depolymerize microtubules in an ATP hydrolysis-dependent manner. The coupling between these two activities remains unclear. Here, we first studied the role of the kinesin-13 subfamily-specific loop 2 and of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07e7ba92e661f5fc78fbd5828b2ed69
https://hal.archives-ouvertes.fr/hal-01446760
https://hal.archives-ouvertes.fr/hal-01446760
Autor:
Chunguang Wang, Marcel Knossow, André Sobel, Benoît Gigant, Raimond B. G. Ravelli, Patrick A. Curmi, Fanny Roussi, Michel O. Steinmetz
Publikováno v:
Nature
Nature, Nature Publishing Group, 2005, 435 (7041), pp.519-522. ⟨10.1038/nature03566⟩
Nature, 2005, 435 (7041), pp.519-522. ⟨10.1038/nature03566⟩
Nature, Nature Publishing Group, 2005, 435 (7041), pp.519-522. ⟨10.1038/nature03566⟩
Nature, 2005, 435 (7041), pp.519-522. ⟨10.1038/nature03566⟩
International audience; Vinblastine is one of several tubulin-targeting Vinca alkaloids that have been responsible for many chemotherapeutic successes since their introduction in the clinic as antitumour drugs. In contrast with the two other classes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be00bf4bb2e25896ff9a4aace2cb299b
https://doi.org/10.1038/nature03566
https://doi.org/10.1038/nature03566
Autor:
Michael C. Marden, Thomas Haertlé, Jeanne Grosclaude, Marcel Knossow, Pascale Debey, Frederic Eghiaian, Human Rezaei
Publikováno v:
Productions Animales (17), 45-50. (2004)
Productions animales
Productions animales, Institut National de la Recherche Agronomique, 2004, 17, pp.45-50
Productions animales
Productions animales, Institut National de la Recherche Agronomique, 2004, 17, pp.45-50
Le polymorphisme génétique de la protéine prion ovine associé à des degrés divers de résistance ou de sensibilité à la tremblante ouvre une voie féconde pour comprendre le lien entre les propriétés structurales de la protéine et le méca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58286b7c8144c3796ff31dab8da7e15f
https://doi.org/10.20870/productions-animales.2004.17.hs.3626
https://doi.org/10.20870/productions-animales.2004.17.hs.3626
Autor:
Benoît Gigant, Jérôme Coutant, Martin Gaudier, Eric Guittet, Marcel Knossow, Marie-France Carlier, Maud Hertzog, Dominique Didry, Gérard Didelot, Thomas Preat, Carine van Heijenoort
Publikováno v:
Cell. 117(5):611-623
The widespread beta-thymosin/WH2 actin binding domain has versatile regulatory properties in actin dynamics and motility. beta-thymosins (isolated WH2 domain) maintain monomeric actin in a "sequestered" nonpolymerizable form. In contrast, when repeat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b058a4838f8f3eeca0447c17ac2382c2