Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Marcel, Hrubša"'
Autor:
Alejandro Carazo, Marcel Hrubša, Lukáš Konečný, Catherine Gunaseelan, Jaka Fadraersada, Pavel Skořepa, Markéta Paclíková, František Musil, Jana Karlíčková, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alena Šmahelová, Vladimír Blaha, Přemysl Mladenka
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
AbstractPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was t
Externí odkaz:
https://doaj.org/article/240926563f954eb0a303bf7cf0825291
Autor:
Lukáš Konečný, Marcel Hrubša, Jana Karlíčková, Alejandro Carazo, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alena Šmahelová, Vladimír Blaha, Milan Bláha, Přemysl Mladěnka
Publikováno v:
Nutrients, Vol 15, Iss 8, p 1842 (2023)
Elevated low-density lipoprotein (LDL) cholesterol levels lead to atherosclerosis and platelet hyperaggregability, both of which are known culprits of arterial thrombosis. Normalization of LDL cholesterol in familial hypercholesterolemia (FH) is not
Externí odkaz:
https://doaj.org/article/156359b5421848248bde0c4db94cc5ba
Autor:
Marcel Hrubša, Lukáš Konečný, Markéta Paclíková, Mst Shamima Parvin, Pavel Skořepa, František Musil, Jana Karlíčková, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alejandro Carazo, Alena Šmahelová, Vladimír Blaha, Přemysl Mladěnka
Publikováno v:
Nutrients, Vol 14, Iss 22, p 4798 (2022)
A polyphenol-rich diet has beneficial effects on cardiovascular health. However, dietary polyphenols generally have low bioavailability and reach low plasma concentrations. Small phenolic metabolites of these compounds formed by human microbiota are
Externí odkaz:
https://doaj.org/article/bfc55a3a0a63437689df8135ddb9e254
Autor:
Mst Shamima Parvin, Marcel Hrubša, Jaka Fadraersada, Alejandro Carazo, Jana Karlíčková, Lucie Cahlíková, Jakub Chlebek, Kateřina Macáková, Přemysl Mladěnka
Publikováno v:
Toxins, Vol 14, Iss 7, p 491 (2022)
Isoquinoline alkaloids have multiple biological activities, which might be associated with positive pharmacological effects as well as negative adverse reactions. As bleeding was suggested to be a side effect of the isoquinoline alkaloid berberine, w
Externí odkaz:
https://doaj.org/article/e3005161ac514ba2b27ae769110251cd
Autor:
Marcel Hrubša, Raúl Alva, Mst Shamima Parvin, Kateřina Macáková, Jana Karlíčková, Jaka Fadraersada, Lukáš Konečný, Monika Moravcová, Alejandro Carazo, Přemysl Mladěnka
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 117 (2022)
Flavonoids are associated with positive cardiovascular effects. However, due to their low bioavailability, metabolites are likely responsible for these properties. Recently, one of these metabolites, 4-methylcatechol, was described to be a very poten
Externí odkaz:
https://doaj.org/article/60172e55a63f4923982ab2576e429a7d
Autor:
Marcel Hrubša, Tomáš Siatka, Iveta Nejmanová, Marie Vopršalová, Lenka Kujovská Krčmová, Kateřina Matoušová, Lenka Javorská, Kateřina Macáková, Laura Mercolini, Fernando Remião, Marek Máťuš, Přemysl Mladěnka, on behalf of the OEMONOM
Publikováno v:
Nutrients, Vol 14, Iss 3, p 484 (2022)
This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5. These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can also be synthetized from amino acid tryptophan. All of these vitamins
Externí odkaz:
https://doaj.org/article/2b8551a8d81e487fa4c01bade8d289ee
Autor:
Václav Tvrdý, Marcel Hrubša, Eduard Jirkovský, David Biedermann, Michal Kutý, Kateřina Valentová, Vladimír Křen, Přemysl Mladěnka
Publikováno v:
Nutrients, Vol 13, Iss 12, p 4238 (2021)
Silymarin is known for its hepatoprotective effects. Although there is solid evidence for its protective effects against Amanita phalloides intoxication, only inconclusive data are available for alcoholic liver damage. Since silymarin flavonolignans
Externí odkaz:
https://doaj.org/article/3ab824834ed84756ab426df28469bdbb
Autor:
Lukáš Konečný, Marcel Hrubša, Jana Karlíčková, Alejandro Carazo, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Vladimír Blaha, Milan Bláha, Přemysl Mladěnka
Publikováno v:
Cardiovascular Drugs and Therapy.
Background and aims It is well known that elevated cholesterol is associated with enhanced platelet aggregation and patients suffering from familial hypercholesterolemia (FH) have a high risk of thrombotic cardiovascular events. Although decreasing c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ba33f932a3cb1250ecd6e4ba3292e2
https://doi.org/10.1007/s10557-023-07455-y
https://doi.org/10.1007/s10557-023-07455-y
Autor:
Zuzana Lomozová, Václav Tvrdý, Marcel Hrubša, Maria Carmen Catapano, Kateřina Macáková, David Biedermann, Radim Kučera, Vladimír Křen, Přemysl Mladěnka, Kateřina Valentová
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 679 (2021)
2,3-Dehydrosilybin (DHS) was previously shown to chelate and reduce both copper and iron ions. In this study, similar experiments with 2,3-dehydrosilychristin (DHSCH) showed that this congener of DHS also chelates and reduces both metals. Statistical
Externí odkaz:
https://doaj.org/article/ac9a0b777f054c6cb1f5328f81bf3586
Autor:
Přemysl Mladěnka, Jana Karlíčková, Marcel Hrubša, Elma Veljović, Samija Muratović, Alejandro Carazo, Akash Shivling Mali, Selma Špirtović-Halilović, Luciano Saso, Milan Pour, Kemal Durić
Publikováno v:
Applied Sciences, Vol 10, Iss 14, p 4846 (2020)
Metal chelators can be potentially employed in the treatment of various diseases, ranging from metal overload to neoplastic conditions. Some xanthene derivatives were previously reported to complex metals. Thus, in a search for a novel iron or copper
Externí odkaz:
https://doaj.org/article/f793e56e3fbd40ef9aeb2ee8a6b2097e