Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marcel, Hrubša"'
Autor:
Alejandro Carazo, Marcel Hrubša, Lukáš Konečný, Catherine Gunaseelan, Jaka Fadraersada, Pavel Skořepa, Markéta Paclíková, František Musil, Jana Karlíčková, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alena Šmahelová, Vladimír Blaha, Přemysl Mladenka
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
AbstractPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was t
Externí odkaz:
https://doaj.org/article/240926563f954eb0a303bf7cf0825291
Autor:
Mst Shamima Parvin, Marcel Hrubša, Jaka Fadraersada, Alejandro Carazo, Jana Karlíčková, Lucie Cahlíková, Jakub Chlebek, Kateřina Macáková, Přemysl Mladěnka
Publikováno v:
Toxins, Vol 14, Iss 7, p 491 (2022)
Isoquinoline alkaloids have multiple biological activities, which might be associated with positive pharmacological effects as well as negative adverse reactions. As bleeding was suggested to be a side effect of the isoquinoline alkaloid berberine, w
Externí odkaz:
https://doaj.org/article/e3005161ac514ba2b27ae769110251cd
Autor:
Marcel Hrubša, Raúl Alva, Mst Shamima Parvin, Kateřina Macáková, Jana Karlíčková, Jaka Fadraersada, Lukáš Konečný, Monika Moravcová, Alejandro Carazo, Přemysl Mladěnka
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 117 (2022)
Flavonoids are associated with positive cardiovascular effects. However, due to their low bioavailability, metabolites are likely responsible for these properties. Recently, one of these metabolites, 4-methylcatechol, was described to be a very poten
Externí odkaz:
https://doaj.org/article/60172e55a63f4923982ab2576e429a7d
Autor:
Lukáš Konečný, Marcel Hrubša, Jana Karlíčková, Alejandro Carazo, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Vladimír Blaha, Milan Bláha, Přemysl Mladěnka
Publikováno v:
Cardiovascular Drugs and Therapy.
Background and aims It is well known that elevated cholesterol is associated with enhanced platelet aggregation and patients suffering from familial hypercholesterolemia (FH) have a high risk of thrombotic cardiovascular events. Although decreasing c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ba33f932a3cb1250ecd6e4ba3292e2
https://doi.org/10.1007/s10557-023-07455-y
https://doi.org/10.1007/s10557-023-07455-y
Autor:
Zuzana Lomozová, Václav Tvrdý, Marcel Hrubša, Maria Carmen Catapano, Kateřina Macáková, David Biedermann, Radim Kučera, Vladimír Křen, Přemysl Mladěnka, Kateřina Valentová
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 679 (2021)
2,3-Dehydrosilybin (DHS) was previously shown to chelate and reduce both copper and iron ions. In this study, similar experiments with 2,3-dehydrosilychristin (DHSCH) showed that this congener of DHS also chelates and reduces both metals. Statistical
Externí odkaz:
https://doaj.org/article/ac9a0b777f054c6cb1f5328f81bf3586
Autor:
Přemysl Mladěnka, Jana Karlíčková, Marcel Hrubša, Elma Veljović, Samija Muratović, Alejandro Carazo, Akash Shivling Mali, Selma Špirtović-Halilović, Luciano Saso, Milan Pour, Kemal Durić
Publikováno v:
Applied Sciences, Vol 10, Iss 14, p 4846 (2020)
Metal chelators can be potentially employed in the treatment of various diseases, ranging from metal overload to neoplastic conditions. Some xanthene derivatives were previously reported to complex metals. Thus, in a search for a novel iron or copper
Externí odkaz:
https://doaj.org/article/f793e56e3fbd40ef9aeb2ee8a6b2097e
Autor:
Alejandro Carazo, Marcel Hrubša, Lukáš Konečný, Pavel Skořepa, Markéta Paclíková, František Musil, Jana Karlíčková, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Mst Shamima Parvin, Alena Šmahelová, Vladimír Blaha, Přemysl Mladěnka
Publikováno v:
Seminars in Thrombosis and Hemostasis.
The process of platelet aggregation is often influenced by several factors including sex and age. A literature review confirmed the existence of sex-related differences in platelet aggregation. Although 68 out of 78 papers found such differences, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e76cfe187698b0ac7d393c95525c9d
https://doi.org/10.1055/s-0042-1756703
https://doi.org/10.1055/s-0042-1756703
Autor:
Lukáš Konečný, Marcel Hrubša, Jana Karlíčková, Alejandro Carazo, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alena Šmahelová, Vladimír Blaha, Milan Bláha, Přemysl Mladěnka
Publikováno v:
Nutrients. 15:1842
Elevated low-density lipoprotein (LDL) cholesterol levels lead to atherosclerosis and platelet hyperaggregability, both of which are known culprits of arterial thrombosis. Normalization of LDL cholesterol in familial hypercholesterolemia (FH) is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22ee567dae50b91b3c6ef02542dbb97
https://doi.org/10.3390/nu15081842
https://doi.org/10.3390/nu15081842
Autor:
Marcel Hrubša, Václav Tvrdý, Michal Kutý, Kateřina Valentová, Vladimír Křen, Přemysl Mladěnka
Publikováno v:
Journal of agricultural and food chemistry. 70(20)
The current chelation therapy has several drawbacks, including lack of selectivity, which could lead to trace metal depletion. Consequently, the proper function of metalloenzymes can be disrupted. Flavonoids possess chelating properties and hence int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc495978ac85f63f963cb27adbf08776
https://pubmed.ncbi.nlm.nih.gov/35544338
https://pubmed.ncbi.nlm.nih.gov/35544338
Autor:
Přemysl Mladěnka, Monika Moravcová, Marcel Hrubša, Zuzana Lomozová, Maria Carmen Catapano, Roberta Argento, Eduard Jirkovský, Radim Kučera, Laura Mercolini
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)).
Background:: Cobalt is an essential trace element, but it can also rarely cause cobalt toxicity due to its release from cobalt-containing medical devices. Currently, there are no approved selective cobalt chelators, which would represent an optimal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f3e46f7d19db42ed7396f6c66da36f
https://pubmed.ncbi.nlm.nih.gov/36201264
https://pubmed.ncbi.nlm.nih.gov/36201264