Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marcel, Grogg"'
Autor:
Itai Sharon, Sharon Pinus, Marcel Grogg, Nicolas Moitessier, Donald Hilvert, T. Martin Schmeing
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Cyanophycin synthetase CphA1 polymerizes Asp and Arg into the nitrogen reserve polymer cyanophycin using two active sites. Sharon et al. show CphA1 has a cryptic 3rd active site that cleaves cyanophycin into primers for self-sufficient biosynthesis.
Externí odkaz:
https://doaj.org/article/6933466f88e54f1c93fa676b699a67e6
Autor:
Linda M. D. Markus, Itai Sharon, Kim Munro, Marcel Grogg, Donald Hilvert, Mike Strauss, T. Martin Schmeing
Publikováno v:
Protein Science, 32 (7)
Cyanophycin is a natural polymer composed of a poly-aspartate backbone with arginine attached to each of the aspartate sidechains. Produced by a wide range of bacteria, which mainly use it as a store of fixed nitrogen, it has many promising industria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b302143d92bb460ca1cf9ee7129435ad
https://doi.org/10.1101/2023.04.15.537035
https://doi.org/10.1101/2023.04.15.537035
Autor:
Asfarul S. Haque, Marcel Grogg, Dieter Seebach, T. Martin Schmeing, Andres E. Leschziner, Donald Hilvert, Itai Sharon, Indrajit Lahiri
Publikováno v:
Nature Chemical Biology. 17:1101-1110
Cyanophycin is a natural biopolymer produced by a wide range of bacteria, consisting of a chain of poly-l-Asp residues with l-Arg residues attached to the β-carboxylate sidechains by isopeptide bonds. Cyanophycin is synthesized from ATP, aspartic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3419933ae6155440bab55d20017308
https://doi.org/10.1038/s41589-021-00854-y
https://doi.org/10.1038/s41589-021-00854-y
Autor:
Yasmin Lau, Henry Patrick Oamen, Marcel Grogg, Iuliia Parfenova, Juha Saarikangas, Robin Hannay, Richard Alan Nichols, Donald Hilvert, Yves Barral, Fabrice Caudron
Publikováno v:
Current Biology, 32 (5)
Prion-like proteins are involved in many aspects of cellular physiology, including cellular memory. In response to deceptive courtship, budding yeast escapes pheromone-induced cell-cycle arrest through the coalescence of the G1/S inhibitor Whi3 into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f67987b4b42ca6354afcc8a6a2dfb3e
http://hdl.handle.net/10138/343162
http://hdl.handle.net/10138/343162
Publikováno v:
ACS chemical biology. 17(3)
Cyanophycin is a biopolymer composed of long chains of β-Asp-Arg. It is widespread in nature, being synthesized by many clades of bacteria, which use it as a cellular reservoir of nitrogen, carbon, and energy. Two enzymes are known to produce cyanop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc777a53b2c623a983731724b0c54970
https://pubmed.ncbi.nlm.nih.gov/35179888
https://pubmed.ncbi.nlm.nih.gov/35179888
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1866:130217
Cyanophycinases are serine protease family enzymes which are required for the metabolism of cyanophycin, the natural polymer multi-L-arginyl-poly(L-aspartic acid). Cyanophycinases degrade cyanophycin to β-Asp-Arg dipeptides, which enables use of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ada3e521dafc45463e4b088cb506343
https://doi.org/10.1016/j.bbagen.2022.130217
https://doi.org/10.1016/j.bbagen.2022.130217
Autor:
Juha Saarikangas, Fabrice Caudron, Richard A. Nichols, Yasmin Lau, Yves Barral, Iuliia Parfenova, Donald Hilvert, Marcel Grogg
Publikováno v:
SSRN Electronic Journal.
Prion-like proteins are involved in many aspects of cellular physiology, including cellular memory. In response to deceptive courtship, budding yeast escapes pheromone induced cell cycle arrest through coalescence of the G1/S inhibitor Whi3 into a do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d54878c87138a4ac07fc9b8eb75c3ae7
https://doi.org/10.2139/ssrn.3689781
https://doi.org/10.2139/ssrn.3689781
Publikováno v:
Synthesis. 51:31-39
Novel guanidinium-rich oligopeptide derivatives R-[Adp(X)]8-NH2 are described, which consist of an octa-aspartic acid backbone with argininylated side chains that are derived from the biopolymer cyanophycin [H-(Adp)n-OH]. The Fmoc-Adp(X,Pbf)-OH build
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e088c2332fbe894913c38f757363fd4c
https://doi.org/10.1055/s-0037-1610202
https://doi.org/10.1055/s-0037-1610202
Autor:
Petra Hellwig, Alicia Schirer, Jérémy Ruiz, Régis Boehringer, Marcel Grogg, Vladimir Yu. Torbeev, Gunnar Jeschke, Donald Hilvert
Publikováno v:
Journal of Peptide Science. 22:290-304
Insoluble amyloid fibers represent a pathological signature of many human diseases. To treat such diseases, inhibition of amyloid formation has been proposed as a possible therapeutic strategy. d-Peptides, which possess high proteolytic stability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed488e5dcdf1e7ef35c3b3de7d20e013
https://doi.org/10.1002/psc.2861
https://doi.org/10.1002/psc.2861
Autor:
Christof Sparr, Marcel Grogg, Sergio Wittlin, Felix Kurth, Albert K. Beck, Dieter Seebach, Matthias Rottmann, Marc-Olivier Ebert, Pascal Mäser, Donald Hilvert, Petra S. Dittrich
Publikováno v:
Helvetica Chimica Acta
Helvetica Chimica Acta, 101 (10)
Helvetica Chimica Acta, 101 (10)
Oligo-arginines are thoroughly studied cell-penetrating peptides (CPPs, Figures 1 and 2). Previous in-vitro investigations with the octaarginine salt of the phosphonate fosmidomycin (herbicide and anti-malaria drug) have shown a 40-fold parasitaemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35c2bb51bf8e7ea76a6a8569012a84f