Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marc-Raleigh Brescia"'
Autor:
Lan-Ying Qin, Kurt W. Saionz, Roland E. Dolle, Baldwin John J, Marc-Raleigh Brescia, Joan J. Zhang, James R. Wareing, Ian R. Henderson, Juerg Zimmermann, Axel Metzger, Pascal Rigollier, Hubert Gstach, Andrew G. Cole
Publikováno v:
Tetrahedron Letters. 51:4486-4489
A facile synthesis of novel 2-amino-6-arylmethyl-7-carboxamido-7,8-dihydropyrimido[5,4-f][1,4]thiazepin-5-ones is described. The synthesis was developed on solid phase and was applied to provide a series of analogs in good yield. The key reactions ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612c6229b945ede53f82e56c7f50e463
https://doi.org/10.1016/j.tetlet.2010.06.070
https://doi.org/10.1016/j.tetlet.2010.06.070
Autor:
Hubert Gstach, Andrew G. Cole, Ian R. Henderson, Baldwin John J, Juerg Zimmermann, Roland E. Dolle, Lan-Ying Qin, James R. Wareing, Wolfgang K.-D. Brill, Axel Metzger, Kurt W. Saionz, Marc-Raleigh Brescia
Publikováno v:
Tetrahedron Letters. 50:7082-7085
An efficient and general synthesis of substituted 2-amino-7,8-dihydropteridin-6(5H)-ones using a combination of solution-phase and solid-phase chemistry is described. Solution-phase chemistry was used to produce two pyrimidine regioisomers that were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226ff5b78225e18bf164076aa818b1f5
https://doi.org/10.1016/j.tetlet.2009.10.005
https://doi.org/10.1016/j.tetlet.2009.10.005
Autor:
Ilana L. Stroke, Michael Snider, Marc-Raleigh Brescia, Zahid Hussain, Kenneth C. Appell, Joan J. Zhang, Christopher A. Haskell, Srilatha Simhadri, Ian Henderson, Sofia Ribeiro, Maria L. Webb, Andrew G. Cole
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:200-203
The identification and evaluation of aryl-[1,4]diazepane ureas as functional antagonists of the chemokine receptor CXCR3 are described. Specific examples exhibit IC(50) values of approximately 60 nM in a calcium mobilization functional assay, and dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713c2527f033ea7a7a39473a8e766878
https://doi.org/10.1016/j.bmcl.2005.09.020
https://doi.org/10.1016/j.bmcl.2005.09.020
Publikováno v:
The Journal of Organic Chemistry. 66:4352-4355
Reduction of bicyclic ketal 1 gave functionalized pyran derivatives 7a or 7b in a highly stereoselective manner, depending upon the reduction conditions utilized. For example, treatment of ketal 1 with TiCl4/Et3SiH produced exclusively diol 7b with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131c1378e0944289b818d488488d96cd
https://doi.org/10.1021/jo010252y
https://doi.org/10.1021/jo010252y
Publikováno v:
The Journal of Organic Chemistry. 62:1257-1263
The regioselectivity of Pd-catalyzed malonate or sulfonylacetate addition to dihydropyran derivatives is highly dependent upon the substitution pattern of the dihydropyran nucleus and is governed by electronic, rather than steric factors. In certain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd9706e34808d519a4b089b63a8bd7c
https://doi.org/10.1021/jo961973d
https://doi.org/10.1021/jo961973d
Autor:
Christine R. Kaneski, Stephen E. Miller, Michael J. Harbour, Marc-Raleigh Brescia, Stephanie French
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 8, Pp 1441-1451 (1994)
With the goal of improving the detection of lysosomal sphingolipid hydrolases within intact cells, we have recently synthesized a new fluorophor, O-[4-(1-imidazolyl)butyl]-2,3-dicyano-1,4-hydroquinonyl beta-D-galactopyranoside (Im-DCH-beta-Gal). In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bfb0c7e34cc3c6d8a77fca39b03043
http://www.sciencedirect.com/science/article/pii/S0022227520400859
http://www.sciencedirect.com/science/article/pii/S0022227520400859
Publikováno v:
ChemInform. 28
The regioselectivity of Pd-catalyzed malonate or sulfonylacetate addition to dihydropyran derivatives is highly dependent upon the substitution pattern of the dihydropyran nucleus and is governed by electronic, rather than steric factors. In certain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e320883283bbd092da8db95ccfe97a70
https://doi.org/10.1002/chin.199729121
https://doi.org/10.1002/chin.199729121
Autor:
Brian F. Mcguinness, Marc-Raleigh Brescia, Guizhen Dong, Tara M. Stauffer, Nicole White, Neelima Mannava, Catherine M. Hicks, Ian R. Henderson, Elizabeth Quadros, Yuefei Shao, Andrew G. Cole, Earl F. Kimble, Pamela G. Wines, Laura L. Rokosz
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
A novel series of adenosine A2A receptor antagonists was identified by high-throughput screening of an encoded combinatorial compound collection. The initial hits were optimized for A2A binding affinity, A1 selectivity, and in vitro microsomal stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74b155205aef0e82d52016b6fec8fd5
https://pubmed.ncbi.nlm.nih.gov/20869242
https://pubmed.ncbi.nlm.nih.gov/20869242
Autor:
Marc-Raleigh Brescia, Philip DeShong
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4495fd814f3ec8e79cbf2c44fab5803d
https://doi.org/10.1002/chin.199836099
https://doi.org/10.1002/chin.199836099
Publikováno v:
ChemInform. 32
Reduction of bicyclic ketal 1 gave functionalized pyran derivatives 7a or 7b in a highly stereoselective manner, depending upon the reduction conditions utilized. For example, treatment of ketal 1 with TiCl4/Et3SiH produced exclusively diol 7b with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbee4073b95740c66d0ead225a977a3e
https://doi.org/10.1002/chin.200141030
https://doi.org/10.1002/chin.200141030