Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marc-Antoine Perrin"'
Autor:
Francoise Benedetti, Marc-Antoine Perrin, Franck Chouteau, Sebastien Bosc, Antony Bigot, Nicolas Champion
Publikováno v:
Organic Process Research & Development. 24:762-768
(+)-Oxo-tomaymycin, a naturally occurring substance of the pyrrolo-1,4-benzodiazepine family, was synthesized using a short and efficient route. The key construction of the seven-membered ring by a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c5a19dad282a2333f7635cb6998c957
https://doi.org/10.1021/acs.oprd.0c00009
https://doi.org/10.1021/acs.oprd.0c00009
Autor:
Magali Mathieu, Benoît Robert, Jean-Christophe Carry, Andreas Karlsson, Thomas Bertrand, Laurent Schio, Woody Sherman, Daniel D. Robinson, Hervé Minoux, Marc-Antoine Perrin, Frank Halley
Publikováno v:
Journal of Chemical Information and Modeling. 56:886-894
Phosphoinositide 3-kinases (PI3Ks) are involved in important cellular functions and represent desirable targets for drug discovery efforts, especially related to oncology; however, the four PI3K subtypes (α, β, γ, and δ) have highly similar bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7062d3dd30a4dff5b85c631a6da61290
https://doi.org/10.1021/acs.jcim.5b00641
https://doi.org/10.1021/acs.jcim.5b00641
Autor:
Josep-Lluís Tamarit, Ivo B. Rietveld, Benoît Robert, Maria Barrio, René Céolin, Marc-Antoine Perrin, Gérard Coquerel
Publikováno v:
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, Wiley, 2016, 105 (1), pp.64-70. ⟨10.1016/j.xphs.2015.10.015⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Universitat Politècnica de Catalunya (UPC)
Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, Wiley, 2016, 105 (1), pp.64-70. ⟨10.1016/j.xphs.2015.10.015⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Two polymorphs of the 1:1 fumarate salt of 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester, developed for the treatment of cognitive symptoms of schizophrenia and Alzheimer disease, have been characterized. The 2 crystal structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214a70f0b3a2c3089c731b78717692bb
https://doi.org/10.1016/j.xphs.2015.10.015
https://doi.org/10.1016/j.xphs.2015.10.015
Autor:
Robert A. Stavenger, Douglas L. Huseby, Astrid Rey, Stéphanie Versluys, Stéphane Renard, Pierre Despeyroux, Eric Bacqué, Christoph Poeverlein, Frédéric Jeannot, Jianzhong Huang, Thomas Germe, Sha Cao, Thomas Taillier, Anthony Maxwell, Imène Khichane, Diarmaid Hughes, Michael Mourez, Marc-Antoine Perrin
Publikováno v:
Journal of medicinal chemistry. 61(8)
In our quest for new antibiotics able to address the growing threat of multidrug resistant infections caused by Gram-negative bacteria, we have investigated an unprecedented series of non-quinolone bacterial topoisomerase inhibitors from the Sanofi p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20727283f80f27a607f169df53a3806f
https://pubmed.ncbi.nlm.nih.gov/29596745
https://pubmed.ncbi.nlm.nih.gov/29596745
Publikováno v:
International journal of pharmaceutics. 547(1-2)
Currently, the two technologies primarily used for the manufacturing of nano-crystalline suspensions using top down process (i.e. wet milling) are high pressure homogenization (HPH) and stirred bead milling (SBM). These two technologies are based upo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917787149c03e8e1adfda424bf8a6fb1
https://pubmed.ncbi.nlm.nih.gov/29787896
https://pubmed.ncbi.nlm.nih.gov/29787896
Autor:
Christophe Meyer, Marc-Antoine Perrin, Janine Cossy, Jean-Philippe Krieger, Dominique Lesuisse, Gino Ricci
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2017, 19 (10), pp.2706-2709. ⟨10.1021/acs.orglett.7b01051⟩
Organic Letters, American Chemical Society, 2017, 19 (10), pp.2706-2709. ⟨10.1021/acs.orglett.7b01051⟩
Structurally diverse macrocyclic pyridones can be efficiently synthesized by a rhodium(III)-catalyzed C–H activation/heterocyclization of ω-alkynyl α-substituted acrylic hydroxamates. The use of a O-pivaloyl hydroxamate as directing group was cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361fc9a72b8c052ed4c54e6ce71223d6
https://pubmed.ncbi.nlm.nih.gov/28485944
https://pubmed.ncbi.nlm.nih.gov/28485944
Autor:
Bruno Anxionnat, Benoit Robert, Pascal George, Gino Ricci, Marc-Antoine Perrin, Domingo Gomez Pardo, Janine Cossy
Publikováno v:
The Journal of Organic Chemistry. 79:5935-5938
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83f5cbc7a0bbf37096b7aadd0176a241
https://doi.org/10.1021/jo501209b
https://doi.org/10.1021/jo501209b
Autor:
Jean Pierre Marquette, Andreas Karlsson, Sylvie Monget, Thomas Bertrand, Jean Christophe Carry, Frank Halley, Marc Antoine Perrin, Jean Paul Nicolas, Tsiala Benard, Angela Virone-Oddos, Luc Bertin, Céline Amara, Hélène Bonnevaux, Laurence Delbarre, Gilles Doerflinger, Pierre Yves Abecassis, Youssef El-Ahmad, Véronique Charrier, Victor Certal, Bruno Filoche-Romme, Florence Gruss-Leleu, Sébastien Perron, Alexey Rak, Patrick Richepin, Stephane Guerif, Carlos Garcia-Echeverria, Loic Vincent, Nadine Michot, Magali Mathieu, Véronique Loyau, Olivier Lemaitre, Maurice Brollo, Christoph Lengauer, Houlfa Guizani, Laurent Schio, Fabienne Thompson, Cécile Delorme
Publikováno v:
Journal of Medicinal Chemistry. 57:903-920
Compelling molecular biology publications have reported the implication of phosphoinositide kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported a scientific rationale for the development of PI3Kβ-specific inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85553ea8c69d86eeaefddb3c7297b6
https://doi.org/10.1021/jm401642q
https://doi.org/10.1021/jm401642q
Publikováno v:
Organic Process Research & Development. 17:505-511
Cocrystallization as a purification step was the only way to isolate an active pharmaceutical ingredient with acceptable chemical and physical specifications. The process design controlling chemical quality and polymorphism issues is described, from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1387fa4a3f00550d86e2dc60404abcd
https://doi.org/10.1021/op300214p
https://doi.org/10.1021/op300214p
Publikováno v:
Annales Pharmaceutiques Françaises
Annales Pharmaceutiques Françaises, Elsevier Masson, 2016, 74 (2), pp.129-136. ⟨10.1016/j.pharma.2015.10.005⟩
Annales Pharmaceutiques Françaises, Elsevier Masson, 2016, 74 (2), pp.129-136. ⟨10.1016/j.pharma.2015.10.005⟩
The topological pressure-temperature phase diagram for the dimorphism of spiperone, a potent neuroleptic drug, has been constructed using literature data and improved crystal structures obtained with new crystallographic data from single-crystal X-ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686f51a99d2d153b9e829e7f471d25eb
https://hal-normandie-univ.archives-ouvertes.fr/hal-01928534
https://hal-normandie-univ.archives-ouvertes.fr/hal-01928534
