Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [18F]-FEOBV

Autor: Pedro Rosa-Neto, Marc-André Bédard, Meghmik Aghourian, Jean-Paul Soucy, Rebekah Wickens, Alain Dagher, Camille Legault-Denis, Étienne Aumont

Publikováno v: Parkinsonism & Related Disorders. 91:162-166

Background Severe cholinergic degeneration is known to occur in Parkinson's disease (PD) and is thought to play a primary role in the cognitive decline associated with this disease. Although cholinergic losses occur in all patients with PD, cognitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::644194822fee242307b79d8e90c78da6
https://doi.org/10.1016/j.parkreldis.2021.09.018

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Autor: Justine Y. Hansen, Golia Shafiei, Ross D. Markello, Kelly Smart, Sylvia M. L. Cox, Martin Nørgaard, Vincent Beliveau, Yanjun Wu, Jean-Dominique Gallezot, Étienne Aumont, Stijn Servaes, Stephanie G. Scala, Jonathan M. DuBois, Gabriel Wainstein, Gleb Bezgin, Thomas Funck, Taylor W. Schmitz, R. Nathan Spreng, Marian Galovic, Matthias J. Koepp, John S. Duncan, Jonathan P. Coles, Tim D. Fryer, Franklin I. Aigbirhio, Colm J. McGinnity, Alexander Hammers, Jean-Paul Soucy, Sylvain Baillet, Synthia Guimond, Jarmo Hietala, Marc-André Bédard, Marco Leyton, Eliane Kobayashi, Pedro Rosa-Neto, Melanie Ganz, Gitte M. Knudsen, Nicola Palomero-Gallagher, James M. Shine, Richard E. Carson, Lauri Tuominen, Alain Dagher, Bratislav Misic

Publikováno v: Nature neuroscience 25(11), 1569-1581 (2022). doi:10.1038/s41593-022-01186-3
Hansen, J Y, Shafiei, G, Markello, R D, Smart, K, Cox, S M L, Nørgaard, M, Beliveau, V, Wu, Y, Gallezot, J-D, Aumont, É, Servaes, S, Scala, S G, DuBois, J M, Wainstein, G, Bezgin, G, Funck, T, Schmitz, T W, Spreng, R N, Galovic, M, Koepp, M J, Duncan, J S, Coles, J P, Fryer, T D, Aigbirhio, F I, McGinnity, C J, Hammers, A, Soucy, J-P, Baillet, S, Guimond, S, Hietala, J, Bedard, M-A, Leyton, M, Kobayashi, E, Rosa-Neto, P, Ganz, M, Knudsen, G M, Palomero-Gallagher, N, Shine, J M, Carson, R E, Tuominen, L, Dagher, A & Misic, B 2022, ' Mapping neurotransmitter systems to the structural and functional organization of the human neocortex ', Nature Neuroscience, vol. 25, pp. 1569–1581 . https://doi.org/10.1038/s41593-022-01186-3

Funder: Helmholts International BigBrain Analytics & Learning Laboratory
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f38b473f0a2f07ec39cd40777f19ff9
https://hdl.handle.net/2128/32625

Brain cholinergic alterations in idiopathic REM sleep behaviour disorder: a PET imaging study with 18F-FEOBV

Autor: Camille Legault-Denis, Meghmik Aghourian, Marc-André Bédard, Jean-Paul Soucy, Ronald B. Postuma, Jean-François Gagnon, Amélie Pelletier, Jacques Montplaisir

Publikováno v: Sleep Medicine. 58:35-41

Background REM sleep behaviour disorder (RBD) occurs frequently in patients with synucleinopathies such as Parkinson's disease, dementia with Lewy body, or multiple system atrophy, but may also occur as a prodromal stage of those diseases; and is ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7a304f71f6978b42a861e36b57faa79
https://doi.org/10.1016/j.sleep.2018.12.020

Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV

Autor: Serge Gauthier, Marc-André Bédard, Pedro Rosa-Neto, Jean-Paul Soucy, Alexey Kostikov, Camille Legault-Denis, Paul Gravel, Meghmik Aghourian

Publikováno v: Molecular Psychiatry. 22:1531-1538

18F-fluoroethoxybenzovesamicol (FEOBV) is a new PET radiotracer that binds to the vesicular acetylcholine transporter. In both animals and healthy humans, FEOBV was found sensitive and reliable to characterize presynaptic cholinergic nerve terminals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f88f416fb934a5b8e17573179ac104fd
https://doi.org/10.1038/mp.2017.183

Structural alteration of brain cholinergic systems in a prodromal state of synucleinopathy: The idiopathic REM sleep behaviour disorder

Autor: Camille Legault-Denis, Meghmik Aghourian, Jacques Montplaisir, Jean-Paul Soucy, Marc-André Bédard, Ronald B. Postuma, Rebekah Wickens

Publikováno v: Parkinsonism & Related Disorders. 79:e13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa8840f2ee4130a1ba293a8172057328
https://doi.org/10.1016/j.parkreldis.2020.06.074