Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Marc de la Roche"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Joachim Hanna, Flavio Beke, Louise M. O’Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Th17 cells are critical players in the immunopathology of a range of autoimmune diseases. Here the authors implicate Hedgehog signaling in Th17 polarization and in the immunopathology of intestinal inflammation in murine models and suggest therapeuti
Externí odkaz:
https://doaj.org/article/37d7f063bb4e46ea82ad72c1a4b36302
Autor:
Manuela Urbischek, Helena Rannikmae, Thomas Foets, Katharina Ravn, Marko Hyvönen, Marc de la Roche
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1fff56d245eb4e0aad679a75fc240e63
Autor:
Mariann Bienz, Anthony Corfield, Douglas J. Winton, Marc Fiedler, Thomas Schwarz-Romond, Marc de la Roche, Michael Graeb, Ashraf E.K. Ibrahim, Ciara Metcalfe
APC mutations cause activation of Wnt/β-catenin signaling, which invariably leads to colorectal cancer. Similarly, overexpressed Dvl proteins are potent activators of β-catenin signaling. Screening a large tissue microarray of different staged colo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::598be0e702f84ee90dacb82f261085bb
https://doi.org/10.1158/0008-5472.c.6500046.v1
https://doi.org/10.1158/0008-5472.c.6500046.v1
PDF file - 4151K, Fig S1 Molecular targets of beta-catenin inhibitors. Fig S2 Efficacy and toxicity of beta-catenin inhibitors. Fig S3 Effects of TNKSi on Wnt signaling components. Fig S4 TNKSi-induced Axin degradasomes. Fig S5 TNKSi treatment of COL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf33e360c0541f647a9b5fbe5efd4ec
https://doi.org/10.1158/0008-5472.22400822
https://doi.org/10.1158/0008-5472.22400822
Autor:
Mariann Bienz, Anthony Corfield, Douglas J. Winton, Marc Fiedler, Thomas Schwarz-Romond, Marc de la Roche, Michael Graeb, Ashraf E.K. Ibrahim, Ciara Metcalfe
Supplementary Figures 3-6 from Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bc26d5db10f2c157ea5814084376b9
https://doi.org/10.1158/0008-5472.22381959
https://doi.org/10.1158/0008-5472.22381959
Autor:
Mariann Bienz, Anthony Corfield, Douglas J. Winton, Marc Fiedler, Thomas Schwarz-Romond, Marc de la Roche, Michael Graeb, Ashraf E.K. Ibrahim, Ciara Metcalfe
Supplementary Figure 2 from Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05082d58f28aa25ed093a14097004bcf
https://doi.org/10.1158/0008-5472.22381968.v1
https://doi.org/10.1158/0008-5472.22381968.v1
Autor:
Mariann Bienz, Anthony Corfield, Douglas J. Winton, Marc Fiedler, Thomas Schwarz-Romond, Marc de la Roche, Michael Graeb, Ashraf E.K. Ibrahim, Ciara Metcalfe
Supplementary Figure 8 from Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826f92f54d618e4ce2b24983c4b69141
https://doi.org/10.1158/0008-5472.22381962
https://doi.org/10.1158/0008-5472.22381962
Hyperactive β-catenin drives colorectal cancer, yet inhibiting its activity remains a formidable challenge. Interest is mounting in tankyrase inhibitors (TNKSi), which destabilize β-catenin through stabilizing Axin. Here, we confirm that TNKSi inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ffef9c69e1218b77693596ade4e55b
https://doi.org/10.1158/0008-5472.c.6505691.v1
https://doi.org/10.1158/0008-5472.c.6505691.v1
Autor:
Mariann Bienz, Anthony Corfield, Douglas J. Winton, Marc Fiedler, Thomas Schwarz-Romond, Marc de la Roche, Michael Graeb, Ashraf E.K. Ibrahim, Ciara Metcalfe
Supplementary Figure 1 from Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0564468277a8766f1105cb00250caa97
https://doi.org/10.1158/0008-5472.22381971.v1
https://doi.org/10.1158/0008-5472.22381971.v1