Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Marc Y Donath"'
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291950 (2023)
System xc-, encoded by Slc7a11, is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-factor for enzym
Externí odkaz:
https://doaj.org/article/624534ec57cb4bd6ad03c03c180b9620
Autor:
Mathis Komminoth, Marc Y Donath, Matthias Hepprich, Philipp Schuetz, Claudine A Blum, Beat Mueller, Jean-Luc Reny, Pauline Gosselin, Gautier Breville, Michael Brändle, Christoph Henzen, Jörg D Leuppi, Andreas D Kistler, Robert Thurnheer, Felix Beuschlein, Gottfried Rudofsky, Daniel Aeberli, Peter M Villiger, Stephan Böhm, Irina Chifu, Martin Fassnacht, Gesine Meyer, Jörg Bojunga, Marco Cattaneo, Constantin Sluka, Helga Schneider, Jonas Rutishauser, «TOASST» study group
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0281585 (2023)
BackgroundDespite the widespread use of glucocorticoids in inflammatory and autoimmune disorders, there is uncertainty about the safe cessation of long-term systemic treatment, as data from prospective trials are largely missing. Due to potential dis
Externí odkaz:
https://doaj.org/article/d92743c036874326b2015c43279634bd
Autor:
Fahim Ebrahimi, Sandrine A Urwyler, Philipp Schuetz, Beat Mueller, Luca Bernasconi, Peter Neyer, Marc Y Donath, Mirjam Christ-Crain
Publikováno v:
Endocrine Connections, Vol 8, Iss 6, Pp 701-708 (2019)
Background: Anti-inflammatory treatment with interleukin-1 (IL-1) antagonism decreases both cortisol and adrenocorticotropin hormone (ACTH) levels in individuals with obesity in short term. However, it remains unknown whether these effects persist up
Externí odkaz:
https://doaj.org/article/94e2fbe81fd841daa855bd8f64cb1cea
Autor:
Milica Popovic, Katharina Timper, Eleonora Seelig, Thierry Nordmann, Tobias E Erlanger, Marc Y Donath, Mirjam Christ-Crain
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217800 (2019)
ObjectiveStudies have suggested that arginine vasopressin (AVP) and its surrogate marker copeptin increase during exercise, independently of serum sodium and/or osmolality. In extreme cases, this can lead to runners-induced hyponatremia. Interleukin-
Externí odkaz:
https://doaj.org/article/ebfd0e1a09554fea898032292fe4a115
Autor:
Kaisa Hofwimmer, Joyce de Paula Souza, Narmadha Subramanian, Milica Vujičić, Leila Rachid, Hélène Méreau, Cheng Zhao, Erez Dror, Emelie Barreby, Niklas K. Björkström, Ingrid Wernstedt Asterholm, Marianne Böni-Schnetzler, Daniel T. Meier, Marc Y. Donath, Jurga Laurencikiene
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1
Externí odkaz:
https://doaj.org/article/ba5db9b693c1401681bcd5953d8aed76
Autor:
Cassandra Bazile, Magdy M. Abdel Malik, Courtney Ackeifi, Randy L. Anderson, Roy W. Beck, Marc Y. Donath, Sanjoy Dutta, Joseph A. Hedrick, Stephen R. Karpen, Thomas W. H. Kay, Thomas Marder, Marjana Marinac, Jennifer McVean, Robert Meyer, Jeremy Pettus, Teresa Quattrin, Ruud H. J. Verstegen, Joshua A. Vieth, Esther Latres
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β-cells in the pancreas. This destruction leads to chronic hyperglycemia, necessitating lifelong insulin therapy to manage blood glucose levels. Typ
Externí odkaz:
https://doaj.org/article/3d839e45f08449c58283852ff8e122f0
Autor:
Milica Wälchli-Popovic, Sophie Monnerat, Angela E. Taylor, Lorna C. Gilligan, Lina Schiffer, Wiebke Arlt, Deborah R. Vogt, Christian De Geyter, Nina Hutter, Marc Y. Donath, Gideon Sartorius, Mirjam Christ-Crain
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionChronic low-grade inflammation might contribute to hyperandrogenemia and metabolic complications in polycystic ovary syndrome (PCOS). The proinflammatory cytokine interleukin (IL)-1 stimulates androgen production from ovarian cells, where
Externí odkaz:
https://doaj.org/article/f9d69dc80b9d4028ad3e110759f5c3fa
Autor:
Thierry M Nordmann, Eleonora Seelig, Katharina Timper, Mareike Cordes, Michael Coslovsky, Henner Hanssen, Arno Schmidt-Trucksäss, Marc Y Donath
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139662 (2015)
Exercise increases muscle derived Interleukin–6 (IL–6) leading to insulin secretion via glucagon-like peptide–1. IL–1 antagonism improves glycemia and decreases systemic inflammation including IL–6 in patients with type 2 diabetes. However,
Externí odkaz:
https://doaj.org/article/42a18915e37244f8bf7fad5d8e6a9597
Autor:
Katharina Timper, Marc Y Donath
Publikováno v:
Swiss Medical Weekly, Vol 142, Iss 2930 (2012)
Already 600 years before Christ, type 2 diabetes was known as a disease of elevated blood sugar levels associated with obesity. Since then, it appears, our understanding of the disease has not changed much, aside from the replacement of tasting the p
Externí odkaz:
https://doaj.org/article/9d09a7c671ea43c98c3c25b643c9a778
Autor:
Sabine Rutti, Nadine S Sauter, Karim Bouzakri, Richard Prazak, Philippe A Halban, Marc Y Donath
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35801 (2012)
A decrease in functional beta-cell mass is a key feature of type 2 diabetes. Glucagon-like peptide 1 (GLP-1) analogues induce proliferation of rodent beta-cells. However, the proliferative capacity of human beta-cells and its modulation by GLP-1 anal
Externí odkaz:
https://doaj.org/article/074f2f63007e4b55b305d501dedae2f6