Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Marc Y, Donath"'
Autor:
Kaisa Hofwimmer, Joyce de Paula Souza, Narmadha Subramanian, Milica Vujičić, Leila Rachid, Hélène Méreau, Cheng Zhao, Erez Dror, Emelie Barreby, Niklas K. Björkström, Ingrid Wernstedt Asterholm, Marianne Böni-Schnetzler, Daniel T. Meier, Marc Y. Donath, Jurga Laurencikiene
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1
Externí odkaz:
https://doaj.org/article/ba5db9b693c1401681bcd5953d8aed76
Autor:
Cassandra Bazile, Magdy M. Abdel Malik, Courtney Ackeifi, Randy L. Anderson, Roy W. Beck, Marc Y. Donath, Sanjoy Dutta, Joseph A. Hedrick, Stephen R. Karpen, Thomas W. H. Kay, Thomas Marder, Marjana Marinac, Jennifer McVean, Robert Meyer, Jeremy Pettus, Teresa Quattrin, Ruud H. J. Verstegen, Joshua A. Vieth, Esther Latres
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β-cells in the pancreas. This destruction leads to chronic hyperglycemia, necessitating lifelong insulin therapy to manage blood glucose levels. Typ
Externí odkaz:
https://doaj.org/article/3d839e45f08449c58283852ff8e122f0
Autor:
Milica Wälchli-Popovic, Sophie Monnerat, Angela E. Taylor, Lorna C. Gilligan, Lina Schiffer, Wiebke Arlt, Deborah R. Vogt, Christian De Geyter, Nina Hutter, Marc Y. Donath, Gideon Sartorius, Mirjam Christ-Crain
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionChronic low-grade inflammation might contribute to hyperandrogenemia and metabolic complications in polycystic ovary syndrome (PCOS). The proinflammatory cytokine interleukin (IL)-1 stimulates androgen production from ovarian cells, where
Externí odkaz:
https://doaj.org/article/f9d69dc80b9d4028ad3e110759f5c3fa
Publikováno v:
Journal of Medical Case Reports, Vol 18, Iss 1, Pp 1-5 (2024)
Abstract Background Amiodarone-induced thyroid dysfunction (AIT) is a side-effect associated with the use of Amiodarone for the treatment of refractory arrythmias. Resulting hyperthyroidism can precipitate cardiac complications, including cardiac isc
Externí odkaz:
https://doaj.org/article/e85f93ee33c24c6eaa1357cc3ec468d3
Autor:
Dan Yedu Quansah, Antje Horsch, Leah Gilbert, Marc Y. Donath, Jardena J. Puder, the MySweetheart research group
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background Women with gestational diabetes mellitus (GDM) have higher insulin resistance and/or reduced secretion, an increased risk of future diabetes and cardiovascular disease, which may be due to a pathological activation of the innate i
Externí odkaz:
https://doaj.org/article/e96a7c02c1c644ffb4c2d4cd7ad4cf10
Autor:
Fabian Wirth, Fabrice D. Heitz, Christine Seeger, Ioana Combaluzier, Karin Breu, Heather C. Denroche, Julien Thevenet, Melania Osto, Paolo Arosio, Julie Kerr-Conte, C. Bruce Verchere, François Pattou, Thomas A. Lutz, Marc Y. Donath, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated
Externí odkaz:
https://doaj.org/article/68eb80d31bdf42208e648a12724a93bf
Autor:
Laura Steiger, Zora Baumann, Lena Keller, Marianne Böni-Schnetzler, Marc Y. Donath, Daniel T. Meier
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102664- (2023)
Summary: Diabetes mellitus is a disease of the hormone-secreting endocrine pancreas. However, increasing evidence suggests that the exocrine pancreas is also involved in the pathogenesis of diabetes. In this protocol, we describe how to harvest both
Externí odkaz:
https://doaj.org/article/a4adfa6dee714ee5bc7936496ec3c8fc
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmune checkpoint inhibitor (ICI) treatment has become important for treating various cancer types, including metastatic renal cell carcinoma. However, ICI treatment can lead to endocrine immune-related adverse events (irAEs) by overstimula
Externí odkaz:
https://doaj.org/article/5533861235464a58bc0518814c1bcc62
Autor:
Daniel T. Meier, Leila Rachid, Sophia J. Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loïc Sauteur, Denise V. Winter, Christelle Le Foll, Catherine Brégère, Raphael Guzman, Alex Odermatt, Marianne Böni-Schnetzler, Marc Y. Donath
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Defective insulin secretion is observed early in the development of diabetes. Here the authors report that β cell-specific deficiency of the insulin prohormone convertase 1/3 (PC1/3) leads not only to hyperglycemia, but also to hyperphagic obesity i
Externí odkaz:
https://doaj.org/article/c2d52d524de146cb95b1f820a6251d26
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291950 (2023)
System xc-, encoded by Slc7a11, is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-factor for enzym
Externí odkaz:
https://doaj.org/article/624534ec57cb4bd6ad03c03c180b9620