Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Marc W. Kirschner"'
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002453 (2024)
To achieve a stable size distribution over multiple generations, proliferating cells require a means of counteracting stochastic noise in the rate of growth, the time spent in various phases of the cell cycle, and the imprecision in the placement of
Externí odkaz:
https://doaj.org/article/4f9cd39d0d4348ca9a9b37992126f0bd
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Antiangiogenic therapy began as an effort to inhibit VEGF signaling, which was thought to be the sole factor driving tumor angiogenesis. It has become clear that there are more pro-angiogenic growth factors that can substitute for VEGF during tumor v
Externí odkaz:
https://doaj.org/article/0f0c4159d5b640939485cac0c285dbec
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cell dry mass is principally determined by the sum of biosynthesis and degradation. Measurable change in dry mass occurs on a time scale of hours. By contrast, cell volume can change in minutes by altering the osmotic conditions. How changes in dry m
Externí odkaz:
https://doaj.org/article/c36aaf146ba24a10a1b94a0090ec2aaf
Autor:
Hak-Min Kim, Jessica A. Weber, Nayoung Lee, Seung Gu Park, Yun Sung Cho, Youngjune Bhak, Nayun Lee, Yeonsu Jeon, Sungwon Jeon, Victor Luria, Amir Karger, Marc W. Kirschner, Ye Jin Jo, Seonock Woo, Kyoungsoon Shin, Oksung Chung, Jae-Chun Ryu, Hyung-Soon Yim, Jung-Hyun Lee, Jeremy S. Edwards, Andrea Manica, Jong Bhak, Seungshic Yum
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background Unique among cnidarians, jellyfish have remarkable morphological and biochemical innovations that allow them to actively hunt in the water column and were some of the first animals to become free-swimming. The class Scyphozoa, or
Externí odkaz:
https://doaj.org/article/e1fd26d5ff15424084977d4ca45721bc
Autor:
Douaa Mugahid, Marian Kalocsay, Xili Liu, Jonathan Scott Gruver, Leonid Peshkin, Marc W Kirschner
Publikováno v:
eLife, Vol 9 (2020)
The Hippo pathway regulates organ size, regeneration, and cell growth by controlling the stability of the transcription factor, YAP (Yorkie in Drosophila). When there is tissue damage, YAP is activated allowing the restoration of homeostatic tissue s
Externí odkaz:
https://doaj.org/article/5ba2af129bfc4e7c9cff75ede41cbfcf
Autor:
Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 721-736 (2017)
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation o
Externí odkaz:
https://doaj.org/article/c7e10a401bf44c62bebdf01874f9fdbe
Autor:
Wenyi Wei, Pier Paolo Pandolfi, Rutao Cui, Marc W. Kirschner, Roderick T. Bronson, Lian Xue, Min Sup Song, Pengda Liu, Christopher Ng, Jacqueline Fung, Kelsey Berry, Jesse M. Katon, Hiroyuki Inuzuka, Jing Liu, Ying Lu, Su-Jung Song, Jinfang Zhang, Qing Yin, Xiangpeng Dai, Juxiang Cao, Ming Chen, Lixin Wan
Depletion of FZR1 leads to BRAF stabilization and subsequent ERK activation. Supplementary Figure S2. Depletion of FZR1 triggers the onset of premature senescence in primary melanocytes. Supplementary Figure S3. APCFZR1 promotes BRAF ubiquitination a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cd0731522660e8f466b82fbc60bcf1
https://doi.org/10.1158/2159-8290.22531404.v1
https://doi.org/10.1158/2159-8290.22531404.v1
Autor:
Erik R. Hanschen, Tara N. Marriage, Patrick J. Ferris, Takashi Hamaji, Atsushi Toyoda, Asao Fujiyama, Rafik Neme, Hideki Noguchi, Yohei Minakuchi, Masahiro Suzuki, Hiroko Kawai-Toyooka, David R. Smith, Halle Sparks, Jaden Anderson, Robert Bakarić, Victor Luria, Amir Karger, Marc W. Kirschner, Pierre M. Durand, Richard E. Michod, Hisayoshi Nozaki, Bradley J. S. C. Olson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The undifferentiated Gonium pectorale represents the initial transition to multicellularity. Here, Bradley Olson, Erik Hanschen and colleagues describe the genome of Gonium pectorale, demonstrating that co-option of the retinoblastoma cell cycle regu
Externí odkaz:
https://doaj.org/article/992e5a79e84e4946ab532b4d08cda741
Autor:
Lev Y. Yampolsky, Yongmin Cho, Marc W. Kirschner, Cora E. Anderson, Millicent N. Ekwudo, Leonid Peshkin, Rachael A Jonas-Closs
Publikováno v:
Biogerontology. 23:85-97
Aging is a multifaceted process of accumulation of damages and waste in cells and tissues; age-related changes in mitochondria and in respiratory metabolism have been in the focus of aging research for decades. Here we investigated age-related change
Autor:
Miriam Bracha Ginzberg, Nancy Chang, Heather D'Souza, Nish Patel, Ran Kafri, Marc W Kirschner
Publikováno v:
eLife, Vol 7 (2018)
Cell size uniformity in healthy tissues suggests that control mechanisms might coordinate cell growth and division. We derived a method to assay whether cellular growth rates depend on cell size, by monitoring how variance in size changes as cells gr
Externí odkaz:
https://doaj.org/article/5c836f7e150042c1a45da7a79e6e4da7