Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Marc W Nolte"'
Autor:
Jennifer Krupka, Frauke May, Thomas Weimer, Ingo Pragst, Christoph Kleinschnitz, Guido Stoll, Con Panousis, Gerhard Dickneite, Marc W Nolte
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146783 (2016)
BACKGROUND AND PURPOSE:Ischemic stroke provokes severe brain damage and remains a predominant disease in industrialized countries. The coagulation factor XII (FXII)-driven contact activation system plays a central, but not yet fully defined pathogeni
Externí odkaz:
https://doaj.org/article/9836f5b3bbb9458a890a7684b9626651
Autor:
Susann Cattepoel, Annette Gaida, Alain Kropf, Marc W Nolte, Reinhard Bolli, Sylvia M Miescher
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161826 (2016)
In relation to the recent trials of Intravenous Immunoglobulin (IVIG) in Alzheimer's Disease (AD) it was demonstrated that different IgG preparations contain varying amounts of natural anti-amyloid β (Aβ) antibodies as measured by ELISA. We therefo
Externí odkaz:
https://doaj.org/article/b43db3f3b2db41c39fbf2a3f39025a45
Autor:
Susann Cattepoel, Alexander Schaub, Miriam Ender, Annette Gaida, Alain Kropf, Ursula Guggisberg, Marc W Nolte, Louis Fabri, Paul A Adlard, David I Finkelstein, Reinhard Bolli, Sylvia M Miescher
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63162 (2013)
Intravenous Immunoglobulin (IVIG) has been proposed as a potential therapeutic for Alzheimer's disease (AD) and its efficacy is currently being tested in mild-to-moderate AD. Earlier studies reported the presence of anti-amyloid beta (Aβ) antibodies
Externí odkaz:
https://doaj.org/article/088171df589246178f0026ae2d98411a
Autor:
Claudia Duehrkop, Yara Banz, Rolf Spirig, Sylvia Miescher, Marc W Nolte, Martin Spycher, Richard A G Smith, Steven H Sacks, Robert Rieben
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72059 (2013)
BACKGROUND:Ischemia/reperfusion injury of lower extremities and associated lung damage may result from thrombotic occlusion, embolism, trauma, or surgical intervention with prolonged ischemia and subsequent restoration of blood flow. This clinical en
Externí odkaz:
https://doaj.org/article/cc69c3666e684bdaa8a06500b0f6f4f5
Autor:
Xi Chen, Dipti Pawaskar, Fiona Glassman, Mark Biondo, Frauke May, Anthony Roberts, Andrew McKenzie, Michael A. Tortorici, Marc W. Nolte, William J. Jusko
Publikováno v:
Clinical and Translational Science. 15:709-720
Factor XII (FXII) is a serine protease involved in multiple cascades, including the kallikrein-kinin system. It may play a role in diseases in which the downstream cascades are dysregulated, such as hereditary angioedema. Garadacimab (CSL312) is a fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c60ab1e3fef2cc740cfc6c314ad35ec
https://doi.org/10.1111/cts.13192
https://doi.org/10.1111/cts.13192
Autor:
Eva Eilers, Vanessa Göb, Con Panousis, Stefan Loroch, Frauke May, Cornelia Schumbrutzki, Bernhard Nieswandt, Ayesha A Baig, Marc W. Nolte, Sarah Beck, Albert Sickmann, David Stegner
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2835-2840
Background Effective inhibition of thrombosis without generating bleeding risks is a major challenge in medicine. Accumulating evidence suggests that this can be achieved by inhibition of coagulation factor XII (FXII), as either its knock-out or inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c937077235d03c710ed312d40c88ae
https://doi.org/10.1111/jth.15488
https://doi.org/10.1111/jth.15488
Autor:
Alex Bobik, Yung-Chih Chen, Maria Wallert, Hamid Hosseini, Angela Huang, Maria Tk Zaldivia, Amy K Searle, Ana Maluenda, Peter Kanellakis, Mark Biondo, Con Panousis, Xiaowei Wang, James D. McFadyen, Jonathan Noonan, Hadi Lioe, Karlheinz Peter, Marc W. Nolte, Paolo Rossato
Publikováno v:
Thrombosis and Haemostasis. 122:196-207
Background 3F7 is a monoclonal antibody targeting the enzymatic pocket of activated factor XII (FXIIa), thereby inhibiting its catalytic activity. Given the emerging role of FXIIa in promoting thromboinflammation, along with its apparent redundancy f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3968547d7313de7fcc026967c4071680
https://doi.org/10.1055/a-1663-8208
https://doi.org/10.1055/a-1663-8208
Autor:
Nadine J.A. Mattheij, Frauke Swieringa, Tom G. Mastenbroek, Michelle A. Berny-Lang, Frauke May, Constance C.F.M.J. Baaten, Paola E.J. van der Meijden, Yvonne M.C. Henskens, Erik A.M. Beckers, Dennis P.L. Suylen, Marc W. Nolte, Tilman M. Hackeng, Owen J.T. McCarty, Johan W.M. Heemskerk, Judith M.E.M. Cosemans
Publikováno v:
Haematologica, Vol 101, Iss 4 (2016)
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen bin
Externí odkaz:
https://doaj.org/article/a3218945d5764b0d8ab4b3ee2b832f09
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 3, Pp 342-354 (2008)
Neural transplantation has been investigated experimentally and clinically for the purpose of developing new treatment options for intractable epilepsy. In the present study we assessed the anticonvulsant efficacy and safety of bilateral allotranspla
Externí odkaz:
https://doaj.org/article/79be94f3de814d89b8ceb1febc2d1bad
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 1, Pp 206-218 (2006)
It is well known that epileptogenesis is associated with widespread neuronal network changes in brain regions adjacent to the seizure focus but also in remote structures including basal ganglia. Besides the superior colliculus, the pedunculopontine t
Externí odkaz:
https://doaj.org/article/19977115e0f1488395377c1f60c62a45