Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Marc Venet"'
Autor:
Dominique Jean-Pierre Mabire, Alain Philippe Poncelet, Anne Simone Josephine Lesage, Ludy van Beijsterveldt, François Paul Bischoff, Ria Wouters, Christophe Adelinet, Yvan Rene Simonnet, Sophie Coupa, Marc Venet
Publikováno v:
Journal of Medicinal Chemistry. 48:2134-2153
We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7727d62ed8ca5b6fa5eb08621ef93b
https://doi.org/10.1021/jm049499o
https://doi.org/10.1021/jm049499o
Autor:
Patrick Rene Angibaud, Eddy Jean Edgard Freyne, Christophe Meyer, Jacky Van Dun, Gerda Smets, Marc Venet, Isabelle Noëlle Constance Pilatte, Laurence Mevellec, Virginie Sophie Poncelet, Bruno Roux, Geert Mannens, Ashis K. Saha, David William End, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patricia Lezouret
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4361-4364
Replacement of the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA series by a 4-methyl-1,2,4-triazol-3-yl group gave us compounds with similar structure-activity relationship profiles showing that this triazole is potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c04ec35bf3fe1b70503850f6984927
https://doi.org/10.1016/j.bmcl.2003.09.043
https://doi.org/10.1016/j.bmcl.2003.09.043
Autor:
Gerda Smets, Laurence Mevellec, Michel Janicot, Pieter Van Remoortere, Bruno Roux, Yannick Aimé Eddy Ligny, Isabelle Noëlle Constance Pilatte, Jacky Van Dun, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patrick Rene Angibaud, Geert Mannens, Marc Venet, David William End, Philippe Muller, Christophe Meyer, Patricia Lezouret, Siegrid Damsch, Eddy Jean Edgard Freyne, Virginie Sophie Poncelet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4365-4369
A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d7d9eb0ec5e2c21ab43464526d04f9
https://doi.org/10.1016/j.bmcl.2003.08.080
https://doi.org/10.1016/j.bmcl.2003.08.080
Autor:
Isabelle Noëlle Constance Pilatte, Walter Wouters, Geert Mannens, Yannick Aimé Eddy Ligny, Marc Venet, Pieter Van Remoortere, David W. End, Philippe Muller, Ann Devine, Patrick Rene Angibaud, Gerda Smets, Jacky Van Dun, Xavier Bourdrez, Stacy Skrzat, Virginie Sophie Poncelet, Eddy Jean Edgard Freyne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1543-1547
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54561efa14f8a494a0c6d5b6e93280
https://doi.org/10.1016/s0960-894x(03)00180-x
https://doi.org/10.1016/s0960-894x(03)00180-x
Autor:
Gerard Charles Sanz, B Janssen, J. Van Dun, L Dillen, C. Van Hove, Walter Wouters, J Van heusden, P Moelans, H Bruwiere, R Van Ginckel, G Willemsens, B.-J. Van Der Leede, Wim Floren, Michel Janicot, Marc Venet
Publikováno v:
British Journal of Cancer
All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b534dd2944d23dbc3395a820b97d63
http://europepmc.org/articles/PMC2375285
http://europepmc.org/articles/PMC2375285
Publikováno v:
Current topics in medicinal chemistry. 3(10)
R115777 (R)-6-amino[(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone is a potent and selective inhibitor of farnesyl protein transferase with significant antitumor effects in vivo subsequent to oral adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dd6f3f8c717cf170d2b549607df2ed3
https://pubmed.ncbi.nlm.nih.gov/12769710
https://pubmed.ncbi.nlm.nih.gov/12769710
Autor:
Terence J. Van Raay, Norman A. Doggett, Gregory M. Landes, John M. Millholland, Luiz F. Onuchic, Glenn Miller, William R. Dackowski, Terry Watnick, Ramond M. Hakim, Gregory G. Germino, Katherine W. Kilnger, Marc Venet, Linda R. Petry, Timothy C. Burn, Feng Qian, Timothy D. Connors
Publikováno v:
Human molecular genetics. 4(4)
The complete genomic sequence of the gene responsible for the predominant form of polycystic kidney disease, PKD1, was determined to provide a framework for understanding the biology and evolution of the gene, and to aid in the development of molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997e47748ff3420366920130c432d60d
https://pubmed.ncbi.nlm.nih.gov/7633406
https://pubmed.ncbi.nlm.nih.gov/7633406
Autor:
Jean-Claude Hardy, Marc Venet
Publikováno v:
Tetrahedron Letters. 23:1255-1256
Refluxing the oximes ( 2 ) of naphtho-[1,8-bc] pyran-3(2H)-one and ( 6 ) of 3 (2H)-benzofuranone with alcoholic hydrogen chloride give the corresponding α-alkoxy-ketones 3 , 4 , 5 and α-chloroketone 7 respectively. This transformation appears to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe588ba721ba6a6fe2061cc4763b7588
https://doi.org/10.1016/s0040-4039(00)87075-6
https://doi.org/10.1016/s0040-4039(00)87075-6