Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Marc Valentine"'
Autor:
Kaitly J. Woodard, Phillip A. Doerfler, Kalin D. Mayberry, Akshay Sharma, Rachel Levine, Jonathan Yen, Virginia Valentine, Lance E. Palmer, Marc Valentine, Mitchell J. Weiss
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
We characterized the human β-like globin transgenes in two mouse models of sickle cell disease (SCD) and tested a genome-editing strategy to induce red blood cell fetal hemoglobin (HbF; α2γ2). Berkeley SCD mice contain four to 22 randomly arranged
Externí odkaz:
https://doaj.org/article/c7a2b29fe3814d94a95e8c2dce8aa30e
Autor:
Maged Zeineldin, Sara Federico, Xiang Chen, Yiping Fan, Beisi Xu, Elizabeth Stewart, Xin Zhou, Jongrye Jeon, Lyra Griffiths, Rosa Nguyen, Jackie Norrie, John Easton, Heather Mulder, Donald Yergeau, Yanling Liu, Jianrong Wu, Collin Van Ryn, Arlene Naranjo, Michael D. Hogarty, Marcin M. Kamiński, Marc Valentine, Shondra M. Pruett-Miller, Alberto Pappo, Jinghui Zhang, Michael R. Clay, Armita Bahrami, Peter Vogel, Seungjae Lee, Anang Shelat, Jay F. Sarthy, Michael P. Meers, Rani E. George, Elaine R. Mardis, Richard K. Wilson, Steven Henikoff, James R. Downing, Michael A. Dyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.
Externí odkaz:
https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd61
Autor:
Lu Wang, Daniel Hiler, Beisi Xu, Issam AlDiri, Xiang Chen, Xin Zhou, Lyra Griffiths, Marc Valentine, Abbas Shirinifard, András Sablauer, Suresh Thiagarajan, Marie-Elizabeth Barabas, Jiakun Zhang, Dianna Johnson, Sharon Frase, Michael A. Dyer
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2601-2614 (2018)
Summary: Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modif
Externí odkaz:
https://doaj.org/article/32826e1ff45b444b95904cbff6ba595c
Autor:
Martine F. Roussel, Charles J. Sherr, Richard J. Gilbertson, Jerold E. Rehg, Marc Valentine, Christopher Calabrese, Olivier Ayrault, Tamar Uziel, Frederique Zindy
Supplementary Figure 2 from Genetic Alterations in Mouse Medulloblastomas and Generation of Tumors De novo from Primary Cerebellar Granule Neuron Precursors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15abb3cb381189c57397b084834e692b
https://doi.org/10.1158/0008-5472.22366980
https://doi.org/10.1158/0008-5472.22366980
Autor:
Martine F. Roussel, Charles J. Sherr, Richard J. Gilbertson, Jerold E. Rehg, Marc Valentine, Christopher Calabrese, Olivier Ayrault, Tamar Uziel, Frederique Zindy
Mice lacking p53 and one or two alleles of the cyclin D–dependent kinase inhibitor p18Ink4c are prone to medulloblastoma development. The tumor frequency is increased by exposing postnatal animals to ionizing radiation at a time when their cerebell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8804d437ca67f306ea35b4966aa58520
https://doi.org/10.1158/0008-5472.c.6495369.v1
https://doi.org/10.1158/0008-5472.c.6495369.v1
Autor:
Martine F. Roussel, Charles J. Sherr, Richard J. Gilbertson, Jerold E. Rehg, Marc Valentine, Christopher Calabrese, Olivier Ayrault, Tamar Uziel, Frederique Zindy
Supplementary Figure 1 from Genetic Alterations in Mouse Medulloblastomas and Generation of Tumors De novo from Primary Cerebellar Granule Neuron Precursors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c37a25438ed8f5b9d3d52c9f5232da0
https://doi.org/10.1158/0008-5472.22366983.v1
https://doi.org/10.1158/0008-5472.22366983.v1
Autor:
Martine F. Roussel, Charles J. Sherr, Richard J. Gilbertson, Jerold E. Rehg, Marc Valentine, Christopher Calabrese, Olivier Ayrault, Tamar Uziel, Frederique Zindy
Supplementary Figure Legends 1-2 from Genetic Alterations in Mouse Medulloblastomas and Generation of Tumors De novo from Primary Cerebellar Granule Neuron Precursors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381ccc205f70a32898a8b68f3692b36b
https://doi.org/10.1158/0008-5472.22366977.v1
https://doi.org/10.1158/0008-5472.22366977.v1
Autor:
Martine F. Roussel, Charles J. Sherr, Richard J. Gilbertson, Jerold E. Rehg, Marc Valentine, Christopher Calabrese, Olivier Ayrault, Tamar Uziel, Frederique Zindy
Supplementary Table 1 from Genetic Alterations in Mouse Medulloblastomas and Generation of Tumors De novo from Primary Cerebellar Granule Neuron Precursors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df30a14ae30514a4739854e1bbd0ae46
https://doi.org/10.1158/0008-5472.22366974
https://doi.org/10.1158/0008-5472.22366974
Autor:
Jeffrey E. Rubnitz, Masayuki Umeda, Todd A. Alonzo, Jenny L. Smith, Sherif Abdelhamed, Jamie L. Maciaszek, Michael Rusch, Ilaria Iacobucci, M. Madan Babu, Jinghui Zhang, Pandurang Kolekar, Evadnie Rampersaud, Jing Ma, Guangchun Song, Gang Wu, Jeffery M. Klco, James R. Downing, Hiroto Inaba, Xiaotu Ma, Melvin Edward Thomas, Scott G. Foy, Evan Parganas, Yanling Liu, Yi-Cheng Wang, Marc Valentine, Bensheng Ju, Stanley Pounds, Juan Martin Barajas, Tamara Westover, Quang Tran, Huiyun Wu, Jonathan Miller, Amanda R. Leonti, Benjamin J. Huang, Michael P. Walsh, Virginia Valentine, Rhonda E. Ries, John Easton, Jason Myers, Andrew B. Kleist, Kohei Hagiwara, Delaram Rahbarinia, Xiao-Long Chen, Ryan Hiltenbrand, Soheil Meshinchi, Liqing Tian, Charles G. Mullighan, Yen-Chun Liu
Publikováno v:
Blood. 138:LBA-4
Children with acute myeloid leukemia (AML) have a dismal prognosis due to a high relapse rate; however, the molecular basis leading to relapsed pediatric AML has not yet been fully characterized. To define the spectrum of alterations common at relaps
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate