Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Marc Symons"'
Autor:
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Abstract Background Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therape
Externí odkaz:
https://doaj.org/article/c1a6ee476fc8474f99b9f1bb007fbe07
Autor:
Michelle P. Kallis, Caroline Maloney, Brandon Blank, Samuel Z. Soffer, Marc Symons, Bettie M. Steinberg
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background Osteosarcoma is a highly metastatic primary bone tumor that predominantly affects adolescents and young adults. A mainstay of treatment in osteosarcoma is removal of the primary tumor. However, surgical excision itself has been im
Externí odkaz:
https://doaj.org/article/44c648378cc6479da2be400cd7e610c4
Autor:
Zonghui Ding, Harshil Dhruv, Aneta Kwiatkowska-Piwowarczyk, Rosamaria Ruggieri, Jean Kloss, Marc Symons, Patrick Pirrotte, Jennifer M. Eschbacher, Nhan L. Tran, Joseph C. Loftus
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 10, Pp 1045-1058 (2018)
Glioblastoma multiforme (GBM) is the most common type of malignant brain tumors in adults and has a dismal prognosis. The highly aggressive invasion of malignant cells into the normal brain parenchyma renders complete surgical resection of GBM tumors
Externí odkaz:
https://doaj.org/article/d137ed84ba9c4ae983ff2f4b5a25f3c4
Autor:
Michelle De Witt, Alexander Gamble, Derek Hanson, Daniel Markowitz, Caitlin Powell, Saleh Al Dimassi, Mark Atlas, John Boockvar, Rosamaria Ruggieri, Marc Symons
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 50-56 (2017)
Abstract The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain tumor tissue, and moreover, it
Externí odkaz:
https://doaj.org/article/23f5ae1dbd7c45a4a3d2781470897b97
Autor:
Anthony J Hesketh, Caroline Maloney, Christopher A Behr, Morris C Edelman, Richard D Glick, Yousef Al-Abed, Marc Symons, Samuel Z Soffer, Bettie M Steinberg
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145197 (2015)
Metastatic Ewing Sarcoma carries a poor prognosis, and novel therapeutics to prevent and treat metastatic disease are greatly needed. Recent evidence demonstrates that tumor-associated macrophages in Ewing Sarcoma are associated with more advanced di
Externí odkaz:
https://doaj.org/article/39b1b778352e467ea54eb906a9826641
Autor:
Ian S Miller, Sebastien Didier, David W Murray, Tia H Turner, Magimairajan Issaivanan, Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95885 (2014)
Glioblastoma is the most malignant and lethal form of astrocytoma, with patients having a median survival time of approximately 15 months with current therapeutic modalities. It is therefore important to identify novel therapeutics. There is mounting
Externí odkaz:
https://doaj.org/article/c78d1e4261434b10b2046c406410ba86
Autor:
Bettie M. Steinberg, Marc Symons, Samuel Z. Soffer, Martin Lesser, Christopher Tzanavaris, Morris Edelman, Michelle P. Kallis, Caroline Maloney
Figure S2 shows that gefitinib has no effect on the size of the primary tumor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0795a32cdae9b672baf6670491fcaad4
https://doi.org/10.1158/1535-7163.22520638.v1
https://doi.org/10.1158/1535-7163.22520638.v1
Autor:
Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons, Shan Sun, Mingzhu He, Lisa Rosen, Magimairajan Vanan, Timothy C. Ryken, Michael E. Berens, Nhan L. Tran, Caitlin Powell, Daniel Markowitz
Lack of radiosensitization of M443 on normal brain cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9996a2a472a5ac4babc093a2e3e37c6f
https://doi.org/10.1158/1535-7163.22508880.v1
https://doi.org/10.1158/1535-7163.22508880.v1
Autor:
Bettie M. Steinberg, Marc Symons, Samuel Z. Soffer, Martin Lesser, Christopher Tzanavaris, Morris Edelman, Michelle P. Kallis, Caroline Maloney
Most patients with osteosarcoma have subclinical pulmonary micrometastases at diagnosis. Mounting evidence suggests that macrophages facilitate metastasis. As the EGFR has been implicated in carcinoma–macrophage cross-talk, in this study, we asked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231ee499074f720c3d91b84184412892
https://doi.org/10.1158/1535-7163.c.6542713.v1
https://doi.org/10.1158/1535-7163.c.6542713.v1
Autor:
Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons, Shan Sun, Mingzhu He, Lisa Rosen, Magimairajan Vanan, Timothy C. Ryken, Michael E. Berens, Nhan L. Tran, Caitlin Powell, Daniel Markowitz
Legends to Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0274bca6b7311f1d51a8ebe393342fd3
https://doi.org/10.1158/1535-7163.22508868
https://doi.org/10.1158/1535-7163.22508868