Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marc Siggel"'
Autor:
Ewa Sitarska, Silvia Dias Almeida, Marianne Sandvold Beckwith, Julian Stopp, Jakub Czuchnowski, Marc Siggel, Rita Roessner, Aline Tschanz, Christer Ejsing, Yannick Schwab, Jan Kosinski, Michael Sixt, Anna Kreshuk, Anna Erzberger, Alba Diz-Muñoz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract To navigate through diverse tissues, migrating cells must balance persistent self-propelled motion with adaptive behaviors to circumvent obstacles. We identify a curvature-sensing mechanism underlying obstacle evasion in immune-like cells. S
Externí odkaz:
https://doaj.org/article/505ca1c735d5448bb63418ff9ca18075
Publikováno v:
SoftwareX, Vol 25, Iss , Pp 101636- (2024)
Cryogenic electron microscopy (cryo-EM) is a key method in structural and cell biology. Analysis of cryo-EM images requires interpretation of noisy, low-resolution densities, which relies on identifying the most probable orientation of macromolecules
Externí odkaz:
https://doaj.org/article/e7e73be7765043318cae0e89b15250d7
Autor:
Josie L. Ferreira, Vojtěch Pražák, Daven Vasishtan, Marc Siggel, Franziska Hentzschel, Annika M. Binder, Emma Pietsch, Jan Kosinski, Friedrich Frischknecht, Tim W. Gilberger, Kay Grünewald
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al. show that Plasmodium does not adhere to a single
Externí odkaz:
https://doaj.org/article/1ec7f99f7ae54d35a6fecfd9f8a89cab
Autor:
Miao Yu, Maziar Heidari, Sofya Mikhaleva, Piau Siong Tan, Sara Mingu, Hao Ruan, Christopher D. Reinkemeier, Agnieszka Obarska-Kosinska, Marc Siggel, Martin Beck, Gerhard Hummer, Edward A. Lemke
Publikováno v:
Nature
The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol1. The central channel of the NPC is filled with hundreds of intrinsically disordered proteins (IDPs) called FG-nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb8110ec2d6f700b049e0d29b16baea
https://doi.org/10.1038/s41586-023-05990-0
https://doi.org/10.1038/s41586-023-05990-0
Autor:
Sergio Lembo, Léanne Strauss, Dorothy Cheng, Joseph Vermeil, Marc Siggel, Mauricio Toro-Nahuelpan, Chii Jou Chan, Jan Kosinski, Matthieu Piel, Olivia Du Roure, Julien Heuvingh, Julia Mahamid, Alba Diz-Muñoz
Animal cell shape changes are controlled by the actomyosin cortex, a peripheral actin network tethered to the plasma membrane by membrane-to-cortex attachment (MCA) proteins. Previous studies have focused on how myosin motors or actin turnover can ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff9c6de9bbc1a81d7542118a3b7c6f6
https://doi.org/10.1101/2023.01.31.526409
https://doi.org/10.1101/2023.01.31.526409
Publikováno v:
The Journal of Chemical Physics
Lipid membranes are integral building blocks of living cells and perform a multitude of biological functions. Currently, molecular simulations of cellular-scale membrane remodeling processes at atomic resolution are extremely difficult, due to their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09471764e5b082f62fe94e4754e6eb39
https://pubmed.ncbi.nlm.nih.gov/36347673
https://pubmed.ncbi.nlm.nih.gov/36347673
Autor:
Josie L Ferreira, Vojtěch Pražák, Daven Vasishtan, Marc Siggel, Franziska Hentzschel, Emma Pietsch, Jan Kosinski, Friedrich Frischknecht, Tim W. Gilberger, Kay Grünewald
The malaria parasite undergoes a series of extensive morphological changes within its human host and mosquito vector. A scaffold of microtubules beneath a peripheral double membrane establishes and maintains the distinct shapes of all infectious form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::451bbdd28a3c1f04bdb8c9f131554c73
https://doi.org/10.1101/2022.04.13.488170
https://doi.org/10.1101/2022.04.13.488170
Autor:
Beata Turonova, Martin Beck, Florian Schmidt, Marc Siggel, Katarzyna Buczak, Agnieszka Obarska-Kosinska, Shyamal Mosalaganti, Gerhard Hummer, Christian E. Zimmerli, Wim J. H. Hagen, Erica Margiotta, Jan Kosinski, Marie-Therese Mackmull
Nuclear pore complexes (NPCs) mediate nucleocytoplasmic transport. Their intricate 120 MDa architecture remains incompletely understood. Here, we report a near-complete structural model of the human NPC scaffold with explicit membrane and in multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74c67cf01cff9d23a20fcf1334cd233a
https://doi.org/10.1101/2021.10.26.465776
https://doi.org/10.1101/2021.10.26.465776
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance For living cells to function, proteins must efficiently navigate the densely packed cytosol. Protein diffusion is slowed down by high viscosity and can come to a complete halt because of nonspecific binding and aggregation. Using molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43531d6c833d15af274c61e0c16a4c7c
http://europepmc.org/articles/PMC6525548
http://europepmc.org/articles/PMC6525548
Autor:
Shyamal Mosalaganti, Agnieszka Obarska-Kosinska, Marc Siggel, Reiya Taniguchi, Beata Turoňová, Christian E Zimmerli, Katarzyna Buczak, Florian H Schmidt, Erica Margiotta, Marie-Therese Mackmull, Wim J H Hagen, Gerhard Hummer, Jan Kosinski, Martin Beck
Publikováno v:
Microscopy and Microanalysis. 28:1114-1114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b873f8fdae405509671f77da4fb8ce0
https://doi.org/10.1017/s1431927622004706
https://doi.org/10.1017/s1431927622004706