The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis

Autor: Marc Schoeler, Sandrine Ellero-Simatos, Till Birkner, Jordi Mayneris-Perxachs, Lisa Olsson, Harald Brolin, Ulrike Loeber, Jamie D. Kraft, Arnaud Polizzi, Marian Martí-Navas, Josep Puig, Antonio Moschetta, Alexandra Montagner, Pierre Gourdy, Christophe Heymes, Hervé Guillou, Valentina Tremaroli, José Manuel Fernández-Real, Sofia K. Forslund, Remy Burcelin, Robert Caesar

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate the impact of dietary lipids on human gut microbio

Externí odkaz: https://doaj.org/article/b3b8887947dd4c14b3e0120418bffa47

GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting

Autor: Marc Schoeler, Thomas Klag, Judith Wendler, Simon Bernhard, Michael Adolph, Andreas Kirschniak, Martin Goetz, Nisar Malek, Jan Wehkamp

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 11 (2018)

Background: To evaluate the benefits of teduglutide in a real-life setting, we analyzed the data of 14 patients with short bowel syndrome treated with teduglutide. Additionally, we studied glucagon-like peptide 2 (GLP-2) receptor expression in sample

Externí odkaz: https://doaj.org/article/449e672a0ee74b119649b46da966f762

Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity

Autor: Alba Carreras, Ara Koh, Anna Hallén, Fredrik Bäckhed, Maria Ilaria Faggi, Hao Wu, Robert Caesar, Antonio Molinaro, Marc Schoeler

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 37, Iss, Pp 100997-(2020)
Molinaro, A, Koh, A, Wu, H, Schoeler, M, Faggi, M I, Carreras, A, Hallen, A, Backhed, F & Caesar, R 2020, ' Hepatic expression of lipopolysaccharide-binding protein ( Lbp ) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity ', Molecular Metabolism, vol. 37, 100997 . https://doi.org/10.1016/j.molmet.2020.100997

Objective Gut-derived inflammatory factors can impair glucose homeostasis, but the underlying mechanisms are not fully understood. In this study, we investigated how hepatic gene expression is regulated by gut colonization status through myeloid diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d291130f495007f9efd551b2e85ce6d3
https://pubmed.ncbi.nlm.nih.gov/32305515

Treatment of short bowel syndrome with GLP-2-analogue Teduglutide - first clinical data from Tuebingen University Hospital, Germany

Autor: Marc Schoeler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8061daefaac3d375e3f4960cdf9c4094
https://doi.org/10.26226/morressier.57c53841d462b80296c9cb48