Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Marc Schmidt"'
Autor:
Tea Babushku, Markus Lechner, Stefanie Ehrenberg, Ursula Rambold, Marc Schmidt-Supprian, Andrew J. Yates, Sanket Rane, Ursula Zimber-Strobl, Lothar J. Strobl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal Zone B (MZB) cells in mice, but the physiology underlying this differentiation pathway is still elusive. Here, we demonstrate that most B cells r
Externí odkaz:
https://doaj.org/article/6e11745d8d724719a32b1e692199e761
Autor:
Ina Rohwedder, Lou Martha Wackerbarth, Kristina Heinig, Annamaria Ballweg, Johannes Altstätter, Myriam Ripphahn, Claudia Nussbaum, Melanie Salvermoser, Susanne Bierschenk, Tobias Straub, Matthias Gunzer, Marc Schmidt-Supprian, Thomas Kolben, Christian Schulz, Averil Ma, Barbara Walzog, Matthias Heinig, Markus Sperandio
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with extrauterine life. By transcriptomic analysis
Externí odkaz:
https://doaj.org/article/e87a9995376c4685aecbb7a8084026ca
Autor:
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101626- (2022)
Objective: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory sign
Externí odkaz:
https://doaj.org/article/2bae8d5e2cd240e7ae3c80f88b871897
Autor:
Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Anja Arner, Daniela Senft, Vindi Jurinovic, Wen-Hsin Liu, Yuqiao Gao, Veronika Dill, Boris Fehse, Claudia D. Baldus, Lorenz Bastian, Lennart Lenk, Denis M. Schewe, Johannes W. Bagnoli, Binje Vick, Jan Philipp Schmid, Alexander Wilhelm, Rolf Marschalek, Philipp J. Jost, Cornelius Miething, Kristoffer Riecken, Marc Schmidt-Supprian, Vera Binder, Irmela Jeremias
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Preclinical molecular models are useful that mimic a patient´s response to targeted therapy. Here, the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft models of acute leukemia to identify indiv
Externí odkaz:
https://doaj.org/article/6e797a213a574904a9cff02ded829844
Autor:
Markus Lechner, Thomas Engleitner, Tea Babushku, Marc Schmidt-Supprian, Roland Rad, Lothar J. Strobl, Ursula Zimber-Strobl
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Notch signalling is central to marginal zone B cell development, but it is unclear what path this development takes in vivo. Here the authors use a mouse that lacks these cells to show that transgenic induction of Notch2 is sufficient for development
Externí odkaz:
https://doaj.org/article/a3cb7509c5204caea9c78545ccf13866
Autor:
Julia Weber, Jorge de la Rosa, Carolyn S. Grove, Markus Schick, Lena Rad, Olga Baranov, Alexander Strong, Anja Pfaus, Mathias J. Friedrich, Thomas Engleitner, Robert Lersch, Rupert Öllinger, Michael Grau, Irene Gonzalez Menendez, Manuela Martella, Ursula Kohlhofer, Ruby Banerjee, Maria A. Turchaninova, Anna Scherger, Gary J. Hoffman, Julia Hess, Laura B. Kuhn, Tim Ammon, Johnny Kim, Günter Schneider, Kristian Unger, Ursula Zimber-Strobl, Mathias Heikenwälder, Marc Schmidt-Supprian, Fengtang Yang, Dieter Saur, Pentao Liu, Katja Steiger, Dmitriy M. Chudakov, Georg Lenz, Leticia Quintanilla-Martinez, Ulrich Keller, George S. Vassiliou, Juan Cadiñanos, Allan Bradley, Roland Rad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Identification of cancer genes altered by non-genetic mechanisms in B-cell lymphoma is challenging. Here, the authors report the development of transposon tools to perform genome-wide recessive screens in vivo and validate identified putative tumor s
Externí odkaz:
https://doaj.org/article/3cd9593b5a3c449085e3011eabf08516
Autor:
Sang Jun Han, Ryan M. Williams, Mihwa Kim, Daniel A. Heller, Vivette D’Agati, Marc Schmidt-Supprian, H. Thomas Lee
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
We determined that renal proximal tubular (PT) NF-κB essential modulator (NEMO) plays a direct and critical role in ischemic acute kidney injury (AKI) using mice lacking renal PT NEMO and by targeted renal PT NEMO inhibition with mesoscale nanoparti
Externí odkaz:
https://doaj.org/article/aff838eae79d4083a6b184cfefa74e13
Autor:
Deepak Bararia, Johannes A. Hildebrand, Sebastian Stolz, Sarah Haebe, Stefan Alig, Christopher P. Trevisani, Francisco Osorio-Barrios, Michael D. Bartoschek, Michael Mentz, Alessandro Pastore, Erik Gaitzsch, Michael Heide, Vindi Jurinovic, Katharina Rautter, Jay Gunawardana, Muhammed B. Sabdia, Monika Szczepanowski, Julia Richter, Wolfram Klapper, Abner Louissaint, Jr., Christina Ludwig, Sebastian Bultmann, Heinrich Leonhardt, Sebastian Eustermann, Karl-Peter Hopfner, Wolfgang Hiddemann, Michael von Bergwelt-Baildon, Christian Steidl, Robert Kridel, Joshua W.D. Tobin, Maher K. Gandhi, David M. Weinstock, Marc Schmidt-Supprian, Menyhárt B. Sárosi, Martina Rudelius, Verena Passerini, Josef Mautner, Oliver Weigert
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We
Externí odkaz:
https://doaj.org/article/0a5e722ca6e94029b574353537c7475f
Autor:
Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β
Externí odkaz:
https://doaj.org/article/c4f9c099f3104cabbf026773512a17d1
Autor:
Sara Elhag, Christopher Stremmel, Annette Zehrer, Josefine Plocke, Roman Hennel, Michaela Keuper, Clarissa Knabe, Julia Winterhalter, Vanessa Gölling, Lukas Tomas, Tobias Weinberger, Maximilian Fischer, Lulu Liu, Franziska Wagner, Michael Lorenz, Konstantin Stark, Hans Häcker, Marc Schmidt-Supprian, Uwe Völker, Martin Jastroch, Kirsten Lauber, Tobias Straub, Barbara Walzog, Elke Hammer, Christian Schulz
Publikováno v:
Cells, Vol 10, Iss 12, p 3564 (2021)
Background: Tissue-resident macrophages have mixed developmental origins. They derive in variable extent from yolk sac (YS) hematopoiesis during embryonic development. Bone marrow (BM) hematopoietic progenitors give rise to tissue macrophages in post
Externí odkaz:
https://doaj.org/article/e412d572581a422fa50461043bf73b94