Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Marc S. Silver"'
1
Chemistry in a microenvironment of low pH, generated with the aid of an immobilized proteinase
Autor: John H. Haskell, Marc S. Silver
Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1039:25-32
α-Chymotrypsin, when immobilized in a collodion membrane, exhibits high activity and remarkable stability. When the immobilized proteinase is exposed to 15 mM ethyl N- acetyl - l - tyrosinate in dilute pH 8.5 buffer it generates a microenvironment w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1769a7778e1df063265e1787a46896a8
https://doi.org/10.1016/0167-4838(90)90222-2
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3
Enzyme-catalyzed condensation reactions which initiate the rapid peptic cleavage of substrates. 1. How the structure of an activating peptide determines its efficiency
Autor: Marc S. Silver, Susan L. T. James
Publikováno v: Biochemistry. 20:3177-3182
The addition of a small peptide can significantly increase the rate at which pepsin cleaves a substrate at pH 4.5. Why? In order to find out, we have determined spectrophotometrically the relative ability of over a dozen peptides to speed the initial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4d71ce26690f933f8d42e3e3789fc9
https://doi.org/10.1021/bi00514a029
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4
Direct observation of complexes formed between recA protein and a fluorescent single-stranded deoxyribonucleic acid derivative
Autor: Marc S. Silver, Alan R. Fersht
Publikováno v: Biochemistry. 21:6066-6072
The reaction of chloroacetaldehyde with single-stranded DNA (ssDNA) yields epsilon DNA, a highly fluorescent substance. The binding of recA protein to epsilon DNA nearly doubles its fluorescence yield. The enhanced fluorescence signals the formation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4bcd54c02a02dd9465bfd7101914ad
https://doi.org/10.1021/bi00267a007
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5
Surprising consequences of the tendency of pepsin to catalyze condensation reactions between small peptides
Autor: Susan L. T. James, Marc S. Silver
Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 743:13-22
Pepsin catalyzes numerous acyl-transfer reactions. Are peptic acyl-enzyme intermediates involved in such reactions? To start, we examine the cleavage of Leu-Trp-Met-Arg at pH 3.4–4.5 in the presence of 25 mM tryptophanamide. Substantial amounts of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5170a58033a9d9a2be44371749ee09a0
https://doi.org/10.1016/0167-4838(83)90412-0
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