Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Marc S Halfon"'
Autor:
Hasiba Asma, Ellen Tieke, Kevin D Deem, Jabale Rahmat, Tiffany Dong, Xinbo Huang, Yoshinori Tomoyasu, Marc S Halfon
Publikováno v:
eLife, Vol 13 (2024)
Annotation of newly sequenced genomes frequently includes genes, but rarely covers important non-coding genomic features such as the cis-regulatory modules—e.g., enhancers and silencers—that regulate gene expression. Here, we begin to remedy this
Externí odkaz:
https://doaj.org/article/e329a1abf011431fb310d50491d5890d
Publikováno v:
PLoS Genetics, Vol 20, Iss 4, p e1010891 (2024)
Transcriptional cis-regulatory modules, e.g., enhancers, control the time and location of metazoan gene expression. While changes in enhancers can provide a powerful force for evolution, there is also significant deep conservation of enhancers for de
Externí odkaz:
https://doaj.org/article/f4ec029db60f4b87a39a6a680b29372d
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0304802 (2024)
The yellow fever mosquito Aedes aegypti is a major disease vector and an increasingly popular emerging model research organism. We present here an improved protocol for the collection, fixation, and preparation of A. aegypti embryos for immunohistoch
Externí odkaz:
https://doaj.org/article/64711a5e8ce543a5b2e89cfb1cf94104
Autor:
Michael L Weinstein, Chad M Jaenke, Hasiba Asma, Matthew Spangler, Katherine A Kohnen, Claire C Konys, Melissa E Williams, Ashley V Williams, Mark Rebeiz, Marc S Halfon, Thomas M Williams
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010653 (2023)
Animal traits develop through the expression and action of numerous regulatory and realizator genes that comprise a gene regulatory network (GRN). For each GRN, its underlying patterns of gene expression are controlled by cis-regulatory elements (CRE
Externí odkaz:
https://doaj.org/article/5c1efe1f4d224614941cd2bc9f03080d
Autor:
Taylor J Atkinson, Marc S Halfon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 9, Iss 13 (2014)
Metazoan life is dependent on the proper temporal and spatial control of gene expression within the many cells—essentially all with the identical genome—that make up the organism. While much is understood about how individual gene regulatory elem
Externí odkaz:
https://doaj.org/article/2a49754e281d4d938f838ba7846da5bd
Autor:
Beatriz Estrada, Sung E Choe, Stephen S Gisselbrecht, Sebastien Michaud, Lakshmi Raj, Brian W Busser, Marc S Halfon, George M Church, Alan M Michelson
Publikováno v:
PLoS Genetics, Vol 2, Iss 2, p e16 (2006)
An important but largely unmet challenge in understanding the mechanisms that govern the formation of specific organs is to decipher the complex and dynamic genetic programs exhibited by the diversity of cell types within the tissue of interest. Here
Externí odkaz:
https://doaj.org/article/d67d84d924ac42b0a755d3eb45df2677
Autor:
Hasiba Asma, Marc S. Halfon
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Identifying transcriptional enhancers and other cis-regulatory modules (CRMs) is an important goal of post-sequencing genome annotation. Computational approaches provide a useful complement to empirical methods for CRM discovery,
Externí odkaz:
https://doaj.org/article/0409e75761264623afb71546494075ec
Autor:
Isabella Schember, Marc S. Halfon
Publikováno v:
Cells, Vol 11, Iss 3, p 510 (2022)
A major driving force behind the evolution of species-specific traits and novel structures is alterations in gene regulatory networks (GRNs). Comprehending evolution therefore requires an understanding of the nature of changes in GRN structure and th
Externí odkaz:
https://doaj.org/article/cbb6ed2f6e474fc2a417d7496c4a4704
Autor:
Joseph Jaeger, Amanda Hellwig, Elizabeth Schiavoni, Bridget Brace-MacDonald, Natalie A. Lamb, Laurene Tumiel-Berhalter, Marc S. Halfon, Arun Vishwanath, Jennifer A. Surtees
PurposeInformation about genomics is increasingly available to mainstream society, with more and more emphasis on using genomic information to make health care decisions. To determine how prepared people are to use this knowledge to make critical hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d658283a7b19bc330c08003502de6a7c
https://doi.org/10.1101/2022.08.26.505444
https://doi.org/10.1101/2022.08.26.505444
Publikováno v:
Insects. 13(7)
We provide here an updated description of the REDfly (Regulatory Element Database for Fly) database of transcriptional regulatory elements, a unique resource that provides regulatory annotation for the genome of Drosophila and other insects. The geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32a3285d7bc72e030f4482f5fecdf07
https://pubmed.ncbi.nlm.nih.gov/35886794
https://pubmed.ncbi.nlm.nih.gov/35886794