Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marc Ruoß"'
Autor:
Ensieh Zahmatkesh, Mohammad Hossein Ghanian, Ibrahim Zarkesh, Zahra Farzaneh, Majid Halvaei, Zahra Heydari, Farideh Moeinvaziri, Amnah Othman, Marc Ruoß, Abbas Piryaei, Roberto Gramignoli, Saeed Yakhkeshi, Andreas Nüssler, Mustapha Najimi, Hossein Baharvand, Massoud Vosough
Publikováno v:
Cells, Vol 10, Iss 6, p 1274 (2021)
Liver organoids (LOs) are receiving considerable attention for their potential use in drug screening, disease modeling, and transplantable constructs. Hepatocytes, as the key component of LOs, are isolated from the liver or differentiated from plurip
Externí odkaz:
https://doaj.org/article/8620bb99979345739ba86bdff8341fca
Autor:
Marc Ruoß, Silas Rebholz, Marina Weimer, Carl Grom-Baumgarten, Kiriaki Athanasopulu, Ralf Kemkemer, Hanno Käß, Sabrina Ehnert, Andreas K. Nussler
Publikováno v:
Journal of Functional Biomaterials, Vol 11, Iss 1, p 17 (2020)
Drug-induced liver toxicity is one of the most common reasons for the failure of drugs in clinical trials and frequent withdrawal from the market. Reasons for such failures include the low predictive power of in vivo studies, that is mainly caused by
Externí odkaz:
https://doaj.org/article/66a8f90c465b428099f9d0f4d8545525
Autor:
Zahra Heydari, Mustapha Najimi, Hamed Mirzaei, Anastasia Shpichka, Marc Ruoss, Zahra Farzaneh, Leila Montazeri, Abbas Piryaei, Peter Timashev, Roberto Gramignoli, Andreas Nussler, Hossein Baharvand, Massoud Vosough
Publikováno v:
Cells, Vol 9, Iss 2, p 304 (2020)
Organ and tissue shortage are known as a crucially important public health problem as unfortunately a small percentage of patients receive transplants. In the context of emerging regenerative medicine, researchers are trying to regenerate and replace
Externí odkaz:
https://doaj.org/article/65c3895557a64ac6bc4e679cc68308a3
Autor:
Marc Ruoß, Vanessa Kieber, Silas Rebholz, Caren Linnemann, Helen Rinderknecht, Victor Häussling, Marina Häcker, Leon H. H. Olde Damink, Sabrina Ehnert, Andreas K. Nussler
Publikováno v:
Methods and Protocols, Vol 3, Iss 1, p 1 (2019)
In order to increase the metabolic activity of human hepatocytes and liver cancer cell lines, many approaches have been reported in recent years. The metabolic activity could be increased mainly by cultivating the cells in 3D systems or co-cultures (
Externí odkaz:
https://doaj.org/article/f8a0e02bc5174a4fb5a845048f76f8eb
Autor:
Andras Franko, Sonja Hartwig, Jörg Kotzka, Marc Ruoß, Andreas K. Nüssler, Alfred Königsrainer, Hans-Ulrich Häring, Stefan Lehr, Andreas Peter
Publikováno v:
Nutrients, Vol 11, Iss 8, p 1795 (2019)
The liver plays a pivotal role in whole-body carbohydrate, lipid, and protein metabolism. One of the key regulators of glucose and lipid metabolism are hepatokines, which are found among the liver secreted proteins, defined as liver secretome. To elu
Externí odkaz:
https://doaj.org/article/cf7f744772b54111a3ee34650cb89b01
Autor:
Victor Häussling, Sebastian Deninger, Laura Vidoni, Helen Rinderknecht, Marc Ruoß, Christian Arnscheidt, Kiriaki Athanasopulu, Ralf Kemkemer, Andreas K. Nussler, Sabrina Ehnert
Publikováno v:
Bioengineering, Vol 6, Iss 3, p 67 (2019)
Human adipose-derived mesenchymal stem/stromal cells (Ad-MSCs) have great potential for bone tissue engineering. Cryogels, mimicking the three-dimensional structure of spongy bone, represent ideal carriers for these cells. We developed poly(2-hydroxy
Externí odkaz:
https://doaj.org/article/8eac14f953a94b4393f9b7787a4e3787
Autor:
Sabrina Ehnert, Romina H. Aspera-Werz, Marc Ruoß, Steven Dooley, Jan G. Hengstler, Silvio Nadalin, Borna Relja, Andreas Badke, Andreas K. Nussler
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2555 (2019)
Almost all patients with chronic liver diseases (CLD) show altered bone metabolism. Depending on the etiology, this manifests in a severe osteoporosis in up to 75% of the affected patients. Due to high prevalence, the generic term hepatic osteodystro
Externí odkaz:
https://doaj.org/article/2aee771e00fd4b9eba0424b458824537
Autor:
Marc Ruoß, Georg Damm, Massoud Vosough, Lisa Ehret, Carl Grom-Baumgarten, Martin Petkov, Silvio Naddalin, Ruth Ladurner, Daniel Seehofer, Andreas Nussler, Sahar Sajadian
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 347 (2019)
Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests of drug metabolism and toxicity. The aim of the present study was to modify liver cancer cel
Externí odkaz:
https://doaj.org/article/88bc65d48ec24517b52114e1aaf394ab
Autor:
Marc Ruoß, Victor Häussling, Frank Schügner, Leon H. H. Olde Damink, Serene M. L. Lee, Liming Ge, Sabrina Ehnert, Andreas K. Nussler
Publikováno v:
Bioengineering, Vol 5, Iss 4, p 86 (2018)
Due to pronounced species differences, hepatotoxicity of new drugs often cannot be detected in animal studies. Alternatively, human hepatocytes could be used, but there are some limitations. The cells are not always available on demand or in sufficie
Externí odkaz:
https://doaj.org/article/10ddd1bbea7c41e3ac8cb323bafb63f4
Autor:
Mohammad Majd Hammour, Amnah Othman, Romina Aspera-Werz, Bianca Braun, Michaela Weis-Klemm, Silvia Wagner, Silvio Nadalin, Tina Histing, Marc Ruoß, Andreas K. Nüssler
Publikováno v:
Archives of toxicology. 96(9)
The HepaRG cell line represents a successful model for hepatotoxicity studies. These cells are of human origin and are differentiated in vitro into mature and functional hepatocyte-like cells. The objective of this research was to compare two differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627e13da0010bae96413612c696b20bf
https://pubmed.ncbi.nlm.nih.gov/35748891
https://pubmed.ncbi.nlm.nih.gov/35748891