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of 4
pro vyhledávání: '"Marc Roddis"'
Publikováno v:
Journal of the American Society for Mass Spectrometry. 13:862-874
Collision induced dissociation sequential mass spectrometry was used to investigate the fragmentation of the heptaketide macrolide aglycones, 6-deoxyerythronolide B (6-dEB), erythronolide B (EB), and acetate-starter EB (Ac-EB). The fragmentations of
Autor:
Laurenz Kellenberger, Peter F. Leadlay, James Staunton, Jesus Cortes, Matthew Deacon, Lars H. Østergaard, Marc Roddis
Publikováno v:
Biochemistry. 41:2719-2726
Multiple ketoreductase activities play a crucial role in establishing the stereochemistry of the products of modular polyketide synthases (PKSs), but there has been little systematic scrutiny of catalysis by individual ketoreductases. To allow this,
Autor:
Alex G. Fallis, Stuart Warren, Ray V.H. Jones, Susan O'Sullivan, Claudio F. Sturino, Bird Paul, Marc Roddis, Martin S. Westwell, Julia M. Worrall, Jason Eames
Publikováno v:
Tetrahedron Letters. 36:1909-1912
The formation of the same cyclic ethers from the sulfenylation of unsaturated alcohols and from acid catalysed phenylthio migration on diols via the same intermediate can be explained by kinetic and thermodynamic control. Both reactions are synthetic
Autor:
Sandeep Handa, James Staunton, Kira J. Weissman, Peter F. Leadlay, Matthew Bycroft, Ulf Hanefeld, Marc Roddis, Elizabeth J. Frost, Máire C. Timoney, Annabel L. Cutter, Rebecca Harris
Publikováno v:
Chemistry & Biology. (12):743-754
Background: Modular polyketide synthases (PKSs) catalyse the biosynthesis of complex polyketides using a different set of enzymes for each successive cycle of chain extension. Directed biosynthesis starting from synthetic diketides is a potentially v