Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marc R. Lake"'
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
N-terminal heterogeneity resulting from non-uniform signal peptide (SP) cleavage can potentially affect biologics property attributes and result in extended product development timelines. Few studies are available on engineering SPs systematically to
Externí odkaz:
https://doaj.org/article/a3718e3c3cd54daba8300f639253fa31
Autor:
Gaurang P Bhide, Natalie E Bohrer, Danying Song, Jeanne Cabel, Marc R Lake, John E Harlan, Laura J Miesbauer
Publikováno v:
Glycobiology.
Monoclonal antibodies comprise a major class of biologic therapeutics and are also extensively studied in immunology. Given the importance of glycans on antibodies, fluorescent labeling of enzymatically released glycans and their LC/MS analysis is ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e7f25022f8c7c4340c4b1f7e4f19231
https://doi.org/10.1093/glycob/cwad020
https://doi.org/10.1093/glycob/cwad020
Autor:
Catherine Zhang, Yoshiko Akamatsu, Alan F. Wahl, Han Kim, Ramesh Iyer, Jeanne M Cabel, Mien Sho, Nicole A. Belmar, Shiming Ye, Patricia Culp, Debra Chao, Marc R. Lake, Siu sze Tan, Cohen Diane Sau Mun, Yuni Fang, Diane Hollenbaugh, Danying Song, Donghee Choi, John Harlan
Publikováno v:
Cancer Immunology Research. 7:1864-1875
Agonistic CD40 monoclonal antibodies (mAb) have demonstrated some clinical activity, but with dose-limiting toxicity. To reduce systemic toxicity, we developed a bispecific molecule that was maximally active in the presence of a tumor antigen and had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ec3a582b90c7996eb5c7dbafda81db
https://doi.org/10.1158/2326-6066.cir-18-0805
https://doi.org/10.1158/2326-6066.cir-18-0805
Autor:
Ramesh Iyer, Ramkrishna Sadhukhan, Amy Greischar, Rui Wang, Jennifer Hardman, Denise C. Perron, B. Sielaff, Maria A. Argiriadi, Ievgeniia Dubrovska, Russell A. Judge, John Harlan, David A. Egan, Lei Gao, Marc R. Lake, Bradford L. McRae, Lorenzo Benatuil, Silvino Sousa
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-13 (2019)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of proinfla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5137f34cb690c34feab4bc20f55765f8
http://link.springer.com/article/10.1186/s12860-019-0213-4
http://link.springer.com/article/10.1186/s12860-019-0213-4
Autor:
Leyu Wang, Viktor Todorović, Ramkrishna Sadhukhan, C. Gerstein, Anil Vasudevan, Henning Stöckmann, Violeta L. Marin, Victoria E. Scott, Marc R. Lake, Paul L. Richardson
Publikováno v:
Journal of the American Chemical Society. 139(46)
Ligand-binding assays are the linchpin of drug discovery and medicinal chemistry. Cell-surface receptors and their ligands have traditionally been characterized by radioligand-binding assays, which have low temporal and spatial resolution and entail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b9b018f82e8732921a3229c8e5ae1c
https://pubmed.ncbi.nlm.nih.gov/29068676
https://pubmed.ncbi.nlm.nih.gov/29068676
Autor:
Steve Kakavas, Kathy M. Krueger, Ana Pereda-Lopez, Timothy A. Esbenshade, Brian R. Estvander, Marc R. Lake, Mark L. Chiu
Publikováno v:
Production of Membrane Proteins: Strategies for Expression and Isolation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c0215037911908ea2d6e50f460ee24
https://doi.org/10.1002/9783527634521.ch4
https://doi.org/10.1002/9783527634521.ch4
Autor:
Jun Guo, Cherrie K. Donawho, Uri S. Ladror, Tzu-Hsuan Huang, Gail Bukofzer, Medha J. Tomlinson, Alexander R. Shoemaker, Xin Lu, Yu Xiao, Bill Pappano, Ramesh B. Lyer, Marc R. Lake, John Harlan
Publikováno v:
Cancer Research. 78:2783-2783
Type 1 IFNs stimulates secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b669b08cb400f26fc329e5ee4e0f142e
https://doi.org/10.1158/1538-7445.am2018-2783
https://doi.org/10.1158/1538-7445.am2018-2783
Autor:
Paul L. Richardson, Victoria E. Scott, Marie E. Uchic, Larry Solomon, Edward T. Olejniczak, Karl A. Walter, Rachel Davis-Taber, Danying Song, Chaohong Sun, Leo W. Barrett, Ana Pereda-Lopez, Philip J. Hajduk, Marc R. Lake
Publikováno v:
Proceedings of the National Academy of Sciences. 104:7875-7880
The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor that contributes to many different cellular functions including neurotransmission, neuronal survival, and synaptic plasticity. The soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c62621b818f70dc9bd76d1e57a970e
https://doi.org/10.1073/pnas.0611397104
https://doi.org/10.1073/pnas.0611397104
Autor:
Wende Niforatos, Karl A. Walter, Marc R. Lake, Thomas F. Holzman, Jun Chen, Victoria E. Scott, Xu-Feng Zhang, Robert B. Moreland, Connie R. Faltynek, Torben R. Neelands
Publikováno v:
Molecular Pharmacology. 71:1209-1216
As a member of the transient receptor potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in nociceptive function and pain states. The endogenous ligands that activate TRPA1 remain unknown. However, various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1613e4384b8edc792bff2c3bbdb6d43
https://doi.org/10.1124/mol.106.033621
https://doi.org/10.1124/mol.106.033621
Publikováno v:
Plant Physiology and Biochemistry. 36:555-562
We cloned a cDNA encoding for the enzyme UDP-glucose-4-epimerase (EC 5.1.3.2; UDP-galactose-4-epimerase or ‘galactowaldenase’) in pea ( Pisum sativum L. cv. Wando). This enzyme functions in the interconversion of UDP-glucose and UDP-galactose. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f45f2169f2f2fee5fa6db41cd6f2ceac
https://doi.org/10.1016/s0981-9428(98)80002-8
https://doi.org/10.1016/s0981-9428(98)80002-8