Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Marc R. Del Bigio"'
Autor:
Marc R. Del Bigio
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2024)
The history of research concerning ependymal cells is reviewed. Cilia were identified along the surface of the cerebral ventricles c1835. Numerous anatomical and histopathological studies in the late 1800’s showed irregularities in the ependymal su
Externí odkaz:
https://doaj.org/article/481625cb00924c1ea6a3daa808e58fa1
Autor:
Prashant Hariharan, Jeffrey Sondheimer, Alexandra Petroj, Jacob Gluski, Andrew Jea, William E. Whitehead, Sandeep Sood, Steven D. Ham, Brandon G. Rocque, Neena I. Marupudi, James P. McAllister, David Limbrick, Marc R. Del Bigio, Carolyn A. Harris
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background Implantation of ventricular catheters (VCs) to drain cerebrospinal fluid (CSF) is a standard approach to treat hydrocephalus. VCs fail frequently due to tissue obstructing the lumen via the drainage holes. Mechanisms driving obstr
Externí odkaz:
https://doaj.org/article/38e2917193ac4764999c8175445c5ce2
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-23 (2019)
Abstract Background Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be studied, it is critical to understand the post-mortem stability of the m
Externí odkaz:
https://doaj.org/article/b8418571732642d4b96d900880d1f962
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Rett Syndrome (RTT) is a rare and progressive neurodevelopmental disorder that is caused by de novo mutations in the X-linked Methyl CpG binding protein 2 (MECP2) gene and is subjected to X-chromosome inactivation. RTT is commonly associated with neu
Externí odkaz:
https://doaj.org/article/206a236184654a22828c914682f0aecf
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-7 (2018)
Abstract Prior research on 3-week hydrocephalic rats showed that behavioral deficits and white matter damage could be reduced by treatment with Ca2+ channel blocker nimodipine. We hypothesized that treatment with nimodipine would be also beneficial t
Externí odkaz:
https://doaj.org/article/a6667fa19a434c98a201a94bf1852745
Autor:
Margaret Stromecki, Nazanin Tatari, Ludivine Coudière Morrison, Ravinder Kaur, Jamie Zagozewski, Gareth Palidwor, Vijay Ramaswamy, Patryk Skowron, Matthias Wölfl, Till Milde, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski‐Ogilvie
Publikováno v:
Molecular Oncology, Vol 12, Iss 4, Pp 495-513 (2018)
Medulloblastoma (MB) is the most common malignant primary pediatric brain cancer. Among the most aggressive subtypes, Group 3 and Group 4 originate from stem/progenitor cells, frequently metastasize, and often display the worst prognosis, yet we know
Externí odkaz:
https://doaj.org/article/7bf98c7755da4eec9545cf267075d874
Autor:
Carl O. Olson, Shervin Pejhan, Daniel Kroft, Kimia Sheikholeslami, David Fuss, Marjorie Buist, Annan Ali Sher, Marc R. Del Bigio, Yehezkel Sztainberg, Victoria Mok Siu, Lee Cyn Ang, Marianne Sabourin-Felix, Tom Moss, Mojgan Rastegar
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Rett syndrome (RTT) is a severe and rare neurological disorder that is caused by mutations in the X-linked MECP2 (methyl CpG-binding protein 2) gene. MeCP2 protein is an important epigenetic factor in the brain and in neurons. In Mecp2-deficient neur
Externí odkaz:
https://doaj.org/article/d5ec5417e1f1402e90cc3f8fa5bb1e26
Autor:
Ravinder Kaur, Christopher Aiken, Ludivine Coudière Morrison, Radhika Rao, Marc R. Del Bigio, Shravanti Rampalli, Tamra Werbowetski-Ogilvie
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1295-1309 (2015)
Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor and is currently divided into four subtypes based on different genomic alterations, gene expression profiles and response to treatment: WNT, Sonic Hedgehog (SHH), Group 3
Externí odkaz:
https://doaj.org/article/7e2bdd6dd2694f62bfe3aa3c28fe64d9
Autor:
Vichithra R. B. Liyanage, Jessica S. Jarmasz, Nanditha Murugeshan, Marc R. Del Bigio, Mojgan Rastegar, James R. Davie
Publikováno v:
Biology, Vol 3, Iss 4, Pp 670-723 (2014)
Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins,
Externí odkaz:
https://doaj.org/article/f912d4666c46434ca808c1b797b5e8cb
Autor:
Ludivine Coudière Morrison, Robyn McClelland, Christopher Aiken, Melissa Bridges, Lisa Liang, Xin Wang, Domenico Di Curzio, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 384-398 (2013)
Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Major research efforts have focused on characterizing and targeting putative brain tumor stem or propagating cell populations from the tumor mass. However, less is known
Externí odkaz:
https://doaj.org/article/c705e165a84e4c54bfb64e66eae22e4e