Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marc R. Arnone"'
Autor:
Alastair J King, Marc R Arnone, Maureen R Bleam, Katherine G Moss, Jingsong Yang, Kelly E Fedorowicz, Kimberly N Smitheman, Joseph A Erhardt, Angela Hughes-Earle, Laurie S Kane-Carson, Robert H Sinnamon, Hongwei Qi, Tara R Rheault, David E Uehling, Sylvie G Laquerre
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67583 (2013)
Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK signalling and bypass the need for upstream stimuli occur with high prevalence in melanoma,
Externí odkaz:
https://doaj.org/article/f2ff4fc2ea6640b3bec689c5d38dc373
Autor:
Tara Renae Rheault, Kimberly N. Smitheman, Kimberly G. Petrov, Chao Han, George Adjabeng, Alex G. Waterson, Marc R. Arnone, Alastair J. King, David E. Uehling, Olivia W. Rossanese, Keith R. Hornberger, Scott Howard Dickerson, John Stellwagen, Cynthia M. Rominger, Robert A. Mook
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4436-4440
A potent series of inhibitors against the B-RafV600E kinase have been developed that show excellent activity in cellular assays and good oral bioavailability in rats. The key structural features of the series are an arylsulfonamide headgroup, a thiaz
Autor:
Robert A. Copeland, Zhihong Lai, Tia Lewis, Kang Yan, Peter J. Tummino, Lata T. Gooljarsingh, John J. Kerrigan, Robert H. Sinnamon, Kyung O. Johanson, Christine Fernandes, Marc R. Arnone, Michael Grooms, Hong Zhang, Alastair J. King, Robert B. Kirkpatrick
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7625-7630
Heat shock protein (Hsp)90 is emerging as an important therapeutic target for the treatment of cancer. Two analogues of the Hsp90 inhibitor geldanamycin are currently in clinical trials. Geldanamycin (GA) and its analogues have been reported to bind
Autor:
Robert H. Grafstrom, Charles F. Albright, Steven P. Seitz, Marvin Kendall, Zelda R. Wasserman, Weijun Pan, Marc R. Arnone
Publikováno v:
Journal of Biological Chemistry. 278:27820-27827
The MMP-11 proteinase, also known as stromelysin-3, probably plays an important role in human cancer because MMP-11 is frequently overexpressed in human tumors and MMP-11 levels affect tumorogenesis in mice. Unlike other MMPs, however, human MMP-11 d
Autor:
Marc R. Arnone, Ronald D. Snyder
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 503:21-35
Clastogenicity is frequently observed following treatment of mammalian cells with new chemical entities. This clastogenicity, unless proven otherwise, is assumed to result from the imperfect repair of DNA lesions produced from covalent chemical/DNA i
Autor:
Kelly E. Fedorowicz, Hongwei Qi, Angela Hughes-Earle, Joseph A. Erhardt, Robert H. Sinnamon, Marc R. Arnone, Tara Renae Rheault, Katherine G. Moss, Alastair J. King, Sylvie Laquerre, Jingsong Yang, David E. Uehling, Laurie S. Kane-Carson, Maureen R. Bleam, Kimberly N. Smitheman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e67583 (2013)
PLoS ONE, Vol 8, Iss 7, p e67583 (2013)
Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK signalling and bypass the need for upstream stimuli occur with high prevalence in melanoma,
Autor:
Laurie S. Kane-Carson, Kimberly N. Smitheman, Chao Han, Alex G. Waterson, Marc R. Arnone, Olivia W. Rossanese, David E. Uehling, John Stellwagen, Keith R. Hornberger, Robert A. Mook, Scott Howard Dickerson, Katherine G. Moss, Alastair J. King, Kimberly G. Petrov, Sylvie Laquerre, Ganesh S. Moorthy, George Adjabeng, Tara Renae Rheault
Hyperactive signaling of the MAP kinase pathway resulting from the constitutively active B-Raf(V600E) mutated enzyme has been observed in a number of human tumors, including melanomas. Herein we report the discovery and biological evaluation of GSK21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ece1513b9365faece7d7d536bde0c1
https://europepmc.org/articles/PMC4027516/
https://europepmc.org/articles/PMC4027516/
Autor:
Sarah Cox, Michael D. Boisclair, Charity L. Dean, Philip M. Czerniak, Pieter F. W. Stouten, David A. Nugiel, Steven P. Seitz, Chong-Hwan Chang, Catherine R. Burton, Marc R. Arnone, Lisa M. Sisk, Robert F. Kaltenbach, Barbara A. Harrison, Pamela A. Benfield, Robert H. Grafstrom, Jay A. Markwalder, Susan R. Sherk, Karen A. Rossi, Deborah Doleniak, Peter Worland, George L. Trainor
Publikováno v:
Journal of medicinal chemistry. 47(24)
Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones was identified that inhibit the cyclin-dependent kinase (CDK) 4/cyclin D1 complex-mediated phosphorylation of a protein substrate with IC(50
Autor:
Elisabeth A. Minthorn, Peter F. Lebowitz, Maureen R. Bleam, Marc R. Arnone, Sylvie Laquerre, Daniele Ouellet, Katherine G. Moss, Qi Liu
Publikováno v:
Cancer Research. 71:5035-5035
Background: GSK2118436 is a potent inhibitor of B-Raf, a signal transduction kinase in the MAPK pathway that can be mutated to become an oncogenic driver in several human cancers, including melanomas (70%). GSK2118436 inhibits in a dose dependant man
Autor:
Laurie S. Kane-Carson, John Stellwagen, George Adjabeng, David E. Uehling, Katherine G. Moss, Tara Renae Rheault, Bradley Heidrich, Robert A. Mook, Marc R. Arnone, Jessica Ward, Jingsong Yang, Keith R. Hornberger, Alex G. Waterson, Alastair J. King, Kimberly N. Smitheman, Chao Han, Sylvie Laquerre, Kelly E. Fisher
Publikováno v:
Molecular Cancer Therapeutics. 8:B88-B88
Activation of the Ras-Raf-MEK-ERK pathway has been implicated in a large range of human cancers. Growth factor receptor stimulation by extracellular ligands activates Ras, which then sets in motion a signal transduction cascade through the Raf, MEK a