Zobrazeno 1 - 10 of 124 pro vyhledávání: '"Marc R Mansour"'
1
Akademický článek
A modular protein language modelling approach to immunogenicity prediction.
Autor: Hugh O'Brien, Max Salm, Laura T Morton, Maciej Szukszto, Felix O'Farrell, Charlotte Boulton, Laurence King, Supreet Kaur Bola, Pablo D Becker, Andrew Craig, Morten Nielsen, Yardena Samuels, Charles Swanton, Marc R Mansour, Sine Reker Hadrup, Sergio A Quezada
Publikováno v: PLoS Computational Biology, Vol 20, Iss 11, p e1012511 (2024)
Neoantigen immunogenicity prediction is a highly challenging problem in the development of personalised medicines. Low reactivity rates in called neoantigens result in a difficult prediction scenario with limited training datasets. Here we describe I
Externí odkaz: https://doaj.org/article/d0648697accf4d3db851dc1ee5b36eb3
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2
Akademický článek
Therapeutic targeting of 'undruggable' MYC
Autor: Victor Llombart, Marc R Mansour
Publikováno v: EBioMedicine, Vol 75, Iss , Pp 103756- (2022)
Summary: c-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is dysregulated in ≈70% of human cancers and strong evidence implicates ab
Externí odkaz: https://doaj.org/article/c718c7ed00ef4887a7436619da8de720
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3
Akademický článek
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain
Autor: Shuning He, Marc R Mansour, Mark W Zimmerman, Dong Hyuk Ki, Hillary M Layden, Koshi Akahane, Evisa Gjini, Eric D de Groh, Antonio R Perez-Atayde, Shizhen Zhu, Jonathan A Epstein, A Thomas Look
Publikováno v: eLife, Vol 5 (2016)
Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in Nf1-deficient mice is independent of Nf1’s role in down-modulating RAS-MAPK signaling. We demonstrate in zebrafish that nf1 loss leads to aberrant ac
Externí odkaz: https://doaj.org/article/5441f057e8b24f8894e688432b587875
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5
Akademický článek
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma
Autor: Stien De Coninck, Renate De Smedt, Beatrice Lintermans, Lindy Reunes, Hansen J. Kosasih, Alexandra Reekmans, Lauren M. Brown, Nadine Van Roy, Bruno Palhais, Juliette Roels, Malaika Van der Linden, Jo Van Dorpe, Panagiotis Ntziachristos, Frederik W. van Delft, Marc R. Mansour, Tim Pieters, Tim Lammens, Barbara De Moerloose, Charles E. de Bock, Steven Goossens, Pieter Van Vlierberghe
Publikováno v: Haematologica, Vol 109, Iss 5 (2023)
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are rare aggressive hematologic malignancies. Current treatment consists of intensive chemotherapy leading to 80% overall survival but is associated with severe tox
Externí odkaz: https://doaj.org/article/a08f66779ce943b3bf87b6b00741dfb3
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7
Akademický článek
Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish
Autor: Evisa Gjini, Chang-Bin Jing, Ashley T. Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J. Rodig, Marc R. Mansour, Keith Joung, A. Thomas Look
Publikováno v: Disease Models & Mechanisms, Vol 12, Iss 5 (2019)
Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 (ASXL1) gene are common genetic abnormalities in human myeloid malignancies and induce clonal expansion of mutated hematopoietic stem cells (HSCs). To und
Externí odkaz: https://doaj.org/article/ee5630c8439a4a52a7085e238f64e4e8
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