Výsledky vyhledávání - "Marc R Barnard"

Akademický článek

Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate.

Autor: Hung Chang, Ivan B Yanachkov, Edward J Dix, Milka Yanachkova, Youfu Li, Marc R Barnard, George E Wright, Alan D Michelson, Andrew L Frelinger

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94780 (2014)

Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antago

Externí odkaz: https://doaj.org/article/874ef7e91dfb4fdb80321881bbbe4d83

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Akademický článek

The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors.

Autor: Frank A J L Scheer, Alan D Michelson, Andrew L Frelinger, Heather Evoniuk, Erin E Kelly, Mary McCarthy, Lauren A Doamekpor, Marc R Barnard, Steven A Shea

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24549 (2011)

Platelets are involved in the thromboses that are central to myocardial infarctions and ischemic strokes. Such adverse cardiovascular events have day/night patterns with peaks in the morning (~9 AM), potentially related to endogenous circadian clock

Externí odkaz: https://doaj.org/article/5c6e187182134da1962b88c42b0d7713

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Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia

Autor: James B. Bussel, Michelle A. Berny-Lang, Emily Leven, Marc R. Barnard, W. Beau Mitchell, Alan D. Michelson, Andrew L. Frelinger, Hannah Tamary, Anja J. Gerrits, Sophie L. Brigstocke, Shoshana Revel-Vilk, Sabrina L. Carmichael

Publikováno v: Blood. 126:1367-1378

Because Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) patients have microthrombocytopenia, hemorrhage is a major problem. We asked whether eltrombopag, a thrombopoietic agent, would increase platelet counts, improve platelet acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e922b6bb491f36b81d41f3d076235e
https://doi.org/10.1182/blood-2014-09-602573

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Platelet activation in a population of critically ill dogs as measured with whole blood flow cytometry and thromboelastography

Autor: Scott P. Shaw, Armelle M. de Laforcade, Sean B. Majoy, Marc R. Barnard

Publikováno v: American Journal of Veterinary Research. 76:328-337

OBJECTIVE To determine whether critically ill dogs had increased platelet activation and whether the proportion of activated platelets correlated with severity of illness. ANIMALS 82 dogs in the intensive care unit of a veterinary teaching hospital a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b0b335bd31a7a4d809119c0ca7c725
https://doi.org/10.2460/ajvr.76.4.328

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Platelet Activation and Inhibition iN Sickle cell disease (PAINS) study

Autor: Andrew L. Frelinger, Alan D. Michelson, Joseph A. Jakubowski, Julie K. Brooks, Sabrina L. Zayas, Matthew M. Heeney, Michelle A. Berny-Lang, Marc R. Barnard

Publikováno v: Platelets. 25:27-35

Abstract 5147 Platelet activation/aggregation in sickle cell disease (SCD) may promote tissue ischemia, suggesting antiplatelet therapy may be useful. However, assessing platelet function and the effect of antiplatelet therapy in blood from SCD patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c212c749214eea852b3157b5f1317eb
https://doi.org/10.3109/09537104.2013.770136

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Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

Autor: Sai Nudurupati, Andrew L. Frelinger, Julie K. Brooks, Jingtao Wu, Ronald D. Lee, Michael Lampa, Anu Nigam, Marc R. Barnard, Darcy Mulford, Deepak L. Bhatt, Alan D. Michelson

Publikováno v: Journal of the American College of Cardiology. 61:872-879

Abstract 4356 Background: Platelet inhibition by clopidogrel is highly variable. Patients with reduced inhibition have increased risk for major adverse cardiovascular events. The aim of this study was to determine whether known genetic, drug, dietary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c99575a538b0c0d992100b72d946fc
https://doi.org/10.1016/j.jacc.2012.11.040

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Whole Blood Analysis of Leukocyte-Platelet Aggregates

Autor: Alan D. Michelson, Andrew L. Frelinger, Mark I. Furman, Marc R. Barnard, Lori A. Krueger

Publikováno v: Current Protocols in Cytometry

In inflammatory and thrombotic syndromes, platelets aggregate with circulating leukocytes, especially monocytes and neutrophils. This leukocyte-platelet aggregate formation is initiated primarily through platelet surface expression of P-selectin (CD6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e72b733a6cc0711fee4cf68fb486ecc
https://doi.org/10.1002/cpcy.8

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The Influence of Intermittent Hypoxemia on Platelet Activation in Obese Patients with Obstructive Sleep Apnea

Autor: Mark I. Furman, Alan D. Michelson, Marc R. Barnard, Shilpa Rahangdale, Victor Novack, Atul Malhotra, Andrew L. Frelinger, KE Stevenson, Susie Yim Yeh

Publikováno v: Journal of Clinical Sleep Medicine. :172-178

Objectives:Literature regarding platelet function in obstructive sleep apnea (OSA) has considerable limitations. Given the central role of platelets in atherothrombosis and the known cardiovascular...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7910f4e73ec6ba0ef6cce282d3cbcf04
https://doi.org/10.5664/jcsm.28105

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Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis

Autor: Andrew L. Frelinger, Karin Przyklenk, Hussien A. Al-Shamma, Michael Morgan, Matthew D. Linden, YouFu Li, Marc R. Barnard, John W. Adams, Alan D. Michelson, Peter Whittaker

Publikováno v: Journal of Thrombosis and Haemostasis. 8:331-340

Release of serotonin and activation of serotonin 5HT2A receptors on platelet surfaces is a potent augmentative stimulus for platelet aggregation. However, earlier-generation serotonin receptor antagonists were not successfully exploited as antiplatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3edf0d75e70939f58c81f12bd54cc2
https://doi.org/10.1111/j.1538-7836.2009.03693.x

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Association of Cyclooxygenase-1-Dependent and -Independent Platelet Function Assays With Adverse Clinical Outcomes in Aspirin-Treated Patients Presenting for Cardiac Catheterization

Autor: Andrew L. Frelinger, YouFu Li, Marc R. Barnard, Marsha L. Fox, Mark I. Furman, Douglas J. Christie, Matthew D. Linden, Alan D. Michelson

Publikováno v: Circulation. 120:2586-2596

Background— Poor clinical outcome in aspirin-treated patients has been termed aspirin resistance and may result from inadequate inhibition of platelet cyclooxygenase-1 (COX-1) by aspirin. The objectives of this study were to determine prospectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683dd041a7f1299038560959abb9439f
https://doi.org/10.1161/circulationaha.109.900589

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