Effect of insulin insufficiency on ultrastructure and function in skeletal muscle

Autor: Chantal Kopecky, Michael Haug, Barbara Reischl, Nandan Deshpande, Bikash Manandhar, Thomas W. King, Victoria Lee, Marc R. Wilkins, Margaret Morris, Patsie Polly, Oliver Friedrich, Kerry‐Anne Rye, Blake J. Cochran

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 112-123 (2024)

Abstract Background Decreased insulin availability and high blood glucose levels, the hallmark features of poorly controlled diabetes, drive disease progression and are associated with decreased skeletal muscle mass. We have shown that mice with β�

Externí odkaz: https://doaj.org/article/c9be2adfa87a4331a6dbb7b63f6da60b

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Autor: Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a

Externí odkaz: https://doaj.org/article/6d65b18b91de403488fe5eca204df6be

RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3′UTR required for intermediate vancomycin resistance

Autor: Daniel G. Mediati, Julia L. Wong, Wei Gao, Stuart McKellar, Chi Nam Ignatius Pang, Sylvania Wu, Winton Wu, Brandon Sy, Ian R. Monk, Joanna M. Biazik, Marc R. Wilkins, Benjamin P. Howden, Timothy P. Stinear, Sander Granneman, Jai J. Tree

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, Mediati et al. apply RNase III-CLASH to multidrug-resistant Staphylococcus aureus to characterise the network of

Externí odkaz: https://doaj.org/article/d679ff7794784a6c999945fa7bd9395e

Raspberry ketone diet supplement reduces attraction of sterile male Queensland fruit fly to cuelure by altering expression of chemoreceptor genes

Autor: Mohammed Abul Monjur Khan, Nandan P. Deshpande, Lucas A. Shuttleworth, Terry Osborne, Damian Collins, Marc R. Wilkins, Geoff M. Gurr, Olivia L. Reynolds

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Sterile male Queensland fruit fly, Bactrocera tryoni (Froggatt), fed as immature adults on the plant compound raspberry ketone (RK), show a reduced attraction to cuelure, a synthetic analogue of RK used as an attractant in Male Annihilation

Externí odkaz: https://doaj.org/article/76f0429bc4f64789a72821467bd4e617

Respiratory viral co-infections among SARS-CoV-2 cases confirmed by virome capture sequencing

Autor: Ki Wook Kim, Ira W. Deveson, Chi Nam I. Pang, Malinna Yeang, Zin Naing, Thiruni Adikari, Jillian M. Hammond, Igor Stevanovski, Alicia G. Beukers, Andrey Verich, Simon Yin, David McFarlane, Marc R. Wilkins, Sacha Stelzer-Braid, Rowena A. Bull, Maria E. Craig, Sebastiaan J. van Hal, William D. Rawlinson

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Accumulating evidence supports the high prevalence of co-infections among Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients, and their potential to worsen the clinical outcome of COVID-19. However, there are few data on S

Externí odkaz: https://doaj.org/article/c4c03833f53f460894aa27160ccb23da