Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Marc R, Friedländer"'
Autor:
Johan Reimegård, Marcel Tarbier, Marcus Danielsson, Jens Schuster, Sathishkumar Baskaran, Styliani Panagiotou, Niklas Dahl, Marc R. Friedländer, Caroline J. Gallant
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Here, the authors present SPARC, a scalable approach for simultaneously measuring mRNA expression levels and targeted intracellular protein levels in single cells. They use SPARC to measure dynamic expression changes in human cells during neuronal di
Externí odkaz:
https://doaj.org/article/f42cc4fcda564a3198a2a80c8aee12b4
Autor:
Marcel Tarbier, Sebastian D. Mackowiak, João Frade, Silvina Catuara-Solarz, Inna Biryukova, Eleni Gelali, Diego Bárcena Menéndez, Luis Zapata, Stephan Ossowski, Magda Bienko, Caroline J. Gallant, Marc R. Friedländer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Gene expression covariation can be studied by single-cell RNA sequencing. Here the authors analyze intrinsically covarying gene pairs by eliminating the confounding effects in single-cell experiments and observe covariation of proximal genes and miRN
Externí odkaz:
https://doaj.org/article/1b30aeb9e4ad4e72990215030189e092
Autor:
Wenjing Kang, Bastian Fromm, Anna J. Houben, Eirik Høye, Daniela Bezdan, Carme Arnan, Kim Thrane, Michaela Asp, Rory Johnson, Inna Biryukova, Marc R. Friedländer
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110015- (2021)
Summary: Previous large-scale studies have uncovered many features that determine the processing of microRNA (miRNA) precursors; however, they have been conducted in vitro. Here, we introduce MapToCleave, a method to simultaneously profile processing
Externí odkaz:
https://doaj.org/article/a48756e75c7e4b9698433294be9c47f4
Autor:
Judit Domingo-Prim, Martin Endara-Coll, Franziska Bonath, Sonia Jimeno, Rosario Prados-Carvajal, Marc R. Friedländer, Pablo Huertas, Neus Visa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The exosome is a ribonucleolytic complex that plays part in RNA processing and degradation. Here, the authors reveal an RNA clearance event in homologous recombination and show the function of EXOSC10, a component of the exosome, in the homeostasis o
Externí odkaz:
https://doaj.org/article/8660cb7f19ec4cacaf434de3f58eee41
Autor:
Xin Yan, Zhen Wang, Christopher A. Bishop, Karolin Weitkunat, Xiao Feng, Marcel Tarbier, Jiankai Luo, Marc R. Friedländer, Ralph Burkhardt, Susanne Klaus, Thomas E. Willnow, Matthew N. Poy
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 15-24 (2018)
Objective: The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in ada
Externí odkaz:
https://doaj.org/article/3a0c1c96f60c484fb637862e87d3c2aa
Autor:
Wenjing Kang, Yrin Eldfjell, Bastian Fromm, Xavier Estivill, Inna Biryukova, Marc R. Friedländer
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract We present here miRTrace, the first algorithm to trace microRNA sequencing data back to their taxonomic origins. This is a challenge with profound implications for forensics, parasitology, food control, and research settings where cross-cont
Externí odkaz:
https://doaj.org/article/47f900a9cfb6434682d1d9fd0af9ed9e
Autor:
Sergio Espeso-Gil, Aliaksei Z. Holik, Sarah Bonnin, Shalu Jhanwar, Sandhya Chandrasekaran, Roger Pique-Regi, Júlia Albaigès-Ràfols, Michael Maher, Jon Permanyer, Manuel Irimia, Marc R. Friedländer, Meritxell Pons-Espinal, Schahram Akbarian, Mara Dierssen, Philipp G. Maass, Charlotte N. Hor, Stephan Ossowski
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organiza
Externí odkaz:
https://doaj.org/article/3401930196b94c0bb26144c4e20bf5cc
Autor:
Fanny Langlet, Marcel Tarbier, Rebecca A. Haeusler, Stefania Camastra, Eleuterio Ferrannini, Marc R. Friedländer, Domenico Accili
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 49-60 (2018)
Objectives: Hepatic insulin resistance is a hallmark of type 2 diabetes and obesity. Insulin receptor signaling through AKT and FOXO has important metabolic effects that have traditionally been ascribed to regulation of gene expression. However, whet
Externí odkaz:
https://doaj.org/article/88dea607494c4d5a8f17c43347252fd5
Publikováno v:
RNA (New York, N.Y.). 28(6)
Over the last few years, the number of microRNAs in the human genome has become a controversially debated issue. Several publications reported thousands of putative novel microRNAs not included in the curated microRNA gene database MirGeneDB and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340242caede05ddc730676d5ef2f8074
https://pubmed.ncbi.nlm.nih.gov/35236776
https://pubmed.ncbi.nlm.nih.gov/35236776
Autor:
Anna E Masser, Wenjing Kang, Joydeep Roy, Jayasankar Mohanakrishnan Kaimal, Jany Quintana-Cordero, Marc R Friedländer, Claes Andréasson
Publikováno v:
eLife, Vol 8 (2019)
Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms
Externí odkaz:
https://doaj.org/article/da724e3aabc248c09d454e29b0a18d68