Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Marc R, Fabian"'
Publikováno v:
Trends in Genetics. 39:401-414
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0769e94d3bf4ab5482847c1a4af9a033
https://doi.org/10.1016/j.tig.2023.01.009
https://doi.org/10.1016/j.tig.2023.01.009
Publikováno v:
eLife, Vol 9 (2020)
EDC4 is a core component of processing (P)-bodies that binds the DCP2 decapping enzyme and stimulates mRNA decay. EDC4 also interacts with mammalian MARF1, a recently identified endoribonuclease that promotes oogenesis and contains a number of RNA bi
Externí odkaz:
https://doaj.org/article/2a9d8c4dbd154405bd634fc367851e06
Publikováno v:
Nucleic Acids Research. 50:7623-7636
Processing bodies (P-bodies) are ribonucleoprotein granules that contain mRNAs, RNA-binding proteins and effectors of mRNA turnover. While P-bodies have been reported to contain translationally repressed mRNAs, a causative role for P-bodies in regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385b2b39321e70ebbacac9c29a1d152c
https://doi.org/10.1093/nar/gkac557
https://doi.org/10.1093/nar/gkac557
Deadenylation-dependent mRNA decapping and decay is the major cytoplasmic mRNA turnover pathway in eukaryotes. Many mRNA decapping and decay factors associate with each other via protein-protein interaction motifs. For example, the decapping enzyme D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::271dc9e528a0236e03c3ddd9f1d4bf26
https://doi.org/10.1101/2023.03.06.531261
https://doi.org/10.1101/2023.03.06.531261
Autor:
Tamiko Nishimura, Zoya Padamsi, Hana Fakim, Simon Milette, Wade H. Dunham, Anne-Claude Gingras, Marc R. Fabian
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1425-1436 (2015)
Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal decay machinery interacts with the 5′-terminal cap structure in order to engende
Externí odkaz:
https://doaj.org/article/dc837888b7fd488ba21070533cca1acb
Autor:
Sam Kajjo, Sahil Sharma, Shan Chen, William R Brothers, Megan Cott, Benedeta Hasaj, Predrag Jovanovic, Ola Larsson, Marc R Fabian
Publikováno v:
EMBO J
Gene expression is tightly regulated at the levels of both mRNA translation and stability. The poly(A)-binding protein (PABP) is thought to play a role in regulating these processes by binding the mRNA 3' poly(A) tail and interacting with both the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e85b729e4545083e83f7be2853051c5
https://europepmc.org/articles/PMC8922270/
https://europepmc.org/articles/PMC8922270/
Autor:
Benoit Coulombe, Elisabeth Meloche, Geneviève Bernard, Raphael Schiffmann, Claudia L. Kleinman, Marc R. Fabian, Marie-Josée Dicaire, Martin Teichmann, Karine Choquet, Adeline Vanderver, Diane Forget, Bernard Brais
Publikováno v:
The Journal of Biological Chemistry
RNA polymerase III (Pol III) is an essential enzyme responsible for the synthesis of several small noncoding RNAs, a number of which are involved in mRNA translation. Recessive mutations in POLR3A, encoding the largest subunit of Pol III, cause POLR3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2acbee3c24d1373ef98044be8c00cc
https://doi.org/10.1074/jbc.ra118.006271
https://doi.org/10.1074/jbc.ra118.006271
Autor:
Rima Ezzeddine, Matthew Dankner, Paul Savage, Steven Hebert, William Brothers, Matthew G. Annis, Sarah M. Maritan, Marc R. Fabian, Claudia Kleinman, Morag Park, Peter M. Siegel
Publikováno v:
Cancer Research. 82:2436-2436
Background: Cold-Inducible RNA Binding Protein (CIRBP) has been implicated in cancer initiation. Moreover, we have previously identified an association of CIRBP with the invasive growth of parenchymal brain metastases. Using a patient-derived xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3d35e458221aea29fd8f66f5d190af1
https://doi.org/10.1158/1538-7445.am2022-2436
https://doi.org/10.1158/1538-7445.am2022-2436
Autor:
Yuri V Svitkin, Akiko Yanagiya, Alexey E Karetnikov, Tommy Alain, Marc R Fabian, Arkady Khoutorsky, Sandra Perreault, Ivan Topisirovic, Nahum Sonenberg
Publikováno v:
PLoS Biology, Vol 11, Iss 5, p e1001564 (2013)
Translation control often operates via remodeling of messenger ribonucleoprotein particles. The poly(A) binding protein (PABP) simultaneously interacts with the 3' poly(A) tail of the mRNA and the eukaryotic translation initiation factor 4G (eIF4G) t
Externí odkaz:
https://doaj.org/article/5d4447b8a6e4451abab1f66500713155
Autor:
Marc R. Fabian, Hana Fakim
Publikováno v:
Methods in Molecular Biology ISBN: 9781071609347
Experiments in cell cultures have been useful for investigating a number of RNA endonucleases. However, endonuclease decay intermediates are often challenging to study in cellulo, as decay intermediates are rapidly degraded by exoribonucleases. Thus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afdfd73608363c82549b4c833810c64f
https://doi.org/10.1007/978-1-0716-0935-4_21
https://doi.org/10.1007/978-1-0716-0935-4_21