Predicting operative mortality in patients who undergo elective open thoracoabdominal aortic aneurysm repairCentral MessagePerspective

Autor: Kyle W. Blackburn, BS, Susan Y. Green, MPH, Allen Kuncheria, BA, Meng Li, PhD, Adel M. Hassan, BA, Brittany Rhoades, PhD, Scott A. Weldon, MA, Subhasis Chatterjee, MD, Marc R. Moon, MD, Scott A. LeMaire, MD, Joseph S. Coselli, MD

Publikováno v: JTCVS Open, Vol 22, Iss , Pp 95-103 (2024)

Background: We have developed a model aimed at identifying preoperative predictors of operative mortality in patients who undergo elective, open thoracoabdominal aortic aneurysm (TAAA) repair. We converted this model into an intuitive nomogram to aid

Externí odkaz: https://doaj.org/article/33c7d2d6d8a04050a4338be9194d6c75

Multiscale mapping of transcriptomic signatures for cardiotoxic drugs

Autor: Jens Hansen, Yuguang Xiong, Mustafa M. Siddiq, Priyanka Dhanan, Bin Hu, Bhavana Shewale, Arjun S. Yadaw, Gomathi Jayaraman, Rosa E. Tolentino, Yibang Chen, Pedro Martinez, Kristin G. Beaumont, Robert Sebra, Dusica Vidovic, Stephan C. Schürer, Joseph Goldfarb, James M. Gallo, Marc R. Birtwistle, Eric A. Sobie, Evren U. Azeloglu, Seth I. Berger, Angel Chan, Christoph Schaniel, Nicole C. Dubois, Ravi Iyengar

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiom

Externí odkaz: https://doaj.org/article/5c705931ae3749d8b0d5c464d5e8d788

Surgical Excision of a Cyclops Lesion After ACL Reconstruction in an Elite College Athlete

Autor: Adam J. Money MD, W. Michael Pullen MD, Marc R. Safran MD, Geoffrey D. Abrams MD, Seth L. Sherman MD

Publikováno v: Video Journal of Sports Medicine, Vol 4 (2024)

Background: Cyclops lesion after anterior cruciate ligament (ACL) reconstruction can appear on magnetic resonance imaging (MRI) in up to 30% of patients and is symptomatic in up to 9%. Arthroscopic cyclops removal can help restore motion and limit re

Externí odkaz: https://doaj.org/article/338d77d484d746498ef03510e61938bf

A modular protein language modelling approach to immunogenicity prediction.

Autor: Hugh O'Brien, Max Salm, Laura T Morton, Maciej Szukszto, Felix O'Farrell, Charlotte Boulton, Laurence King, Supreet Kaur Bola, Pablo D Becker, Andrew Craig, Morten Nielsen, Yardena Samuels, Charles Swanton, Marc R Mansour, Sine Reker Hadrup, Sergio A Quezada

Publikováno v: PLoS Computational Biology, Vol 20, Iss 11, p e1012511 (2024)

Neoantigen immunogenicity prediction is a highly challenging problem in the development of personalised medicines. Low reactivity rates in called neoantigens result in a difficult prediction scenario with limited training datasets. Here we describe I

Externí odkaz: https://doaj.org/article/d0648697accf4d3db851dc1ee5b36eb3

Optimised treatment of patients with enlarged lateral lymph nodes in rectal cancer: protocol of an international, multicentre, prospective registration study after extensive multidisciplinary training (LaNoReC)

Autor: Susan Van Dieren, Joost Nederend, Pieter J Tanis, Roel Hompes, Klaas Havenga, Melissa W Taggart, Robert Riedl, Michail Doukas, Evert-Jan G. Boerma, Marinke Westerterp, Corrie A M Marijnen, Jaap Stoker, Andrew Ruszkiewicz, Tsuyoshi Konishi, Jarno Melenhorst, Karin Muller, Krista Gerbrands, Michael Croft, Michael Wilks, Johanne G. Bloemen, Peter A. Neijenhuis, Koen C.M.J. Peeters, Miranda Kusters, Martijn Intven, Jan Peringa, Maria Verseveld, Eline G M van Geffen, Tania C Sluckin, Sanne-Marije J A Hazen, Karin Horsthuis, Geerard Beets, Marilyne M Lange, Regina G H Beets-Tan, Marc R. W. Engelbrecht, Elisabeth D. Geijsen, Philip Meijnen, Jurriaan B. Tuynman, Ingrid M. Bruijnzeel, Bas Lamme, Femke M. Alberts, Rogier M. P. H. Crolla, Joanne Verdult, Johan H. Wijsman, Charlotte S. van Kessel, Erik Jan Mulder, Jan Binne Hulshoff, Ivan M. Cherepanin, Hans F. J. Fabry, G. Y. Mireille, Frank J. M. Kemper, Fatih Polat, Jacobus W. A. Burger, Jeltsje S. Cnossen, Shira H. de Bie, Robbert J. I. Bosker, Aaldert K. Talsma, Leonora S. F. Boogerd, Marc J. P. M. Govaert, Merel M. Scheurkogel, Imogeen E. Antonisse, Joost Rothbarth, Marianne de Vries, Marcel A. H. Ribbert, Anthony W. H. van de Ven, Susan ter Borg, Jennifer W. Bradshaw, Heleen M. Ceha, Fleur I. de Korte, Andreas W. K. S. Marinelli, Tjeerd S. Aukema, Liselotte W. van Bockel, Aukje A. J. M. van Tilborg, Tom Rozema, Amarins Brandsma, Stefan Hoogendoorn, Saskia R. Offerman, Hanneke Vos, Henderik L. van Westreenen, Jeroen W. A. Leijtens, Fabian A. Holman, Laura A. Velema, L Els, van Persijn van Meerten, Frans C. H. Bakers, Iryna Samarska, Nina Šefčovičová, Maaike Berbée, Bastiaan B. Pultrum, Dennis B. Rouw, Matthew Albert, L. René Arensman, Hanneke Basart, Esther C. J. Consten, Bart C.T. van de Laar, Inne Somers, Paul M. Verheijen, Thomas A. Fassaert, Christiaan Hoff, Eino B. van Duyn, Ellen M. Hendriksen, Hugo A.J. Gielkens, Arend G. J. Aalbers, Brechtje A. Grotenhuis, Michalda S. Dunker, Anne M. van Geel, Christof Meischl, W. Hermien Schreurs, Patty H. Spruit, Michael F. Gerhards, Thomas M. Karsten, Eveline J.T. Krul, Sebastiaan van Koeverden, Andre J. A. Bremers, Heidi Rütten, Johannes H. W. de Wilt, Mariska den Hartogh, Vera Oppedijk, Jan Willem T. Dekker, Debora Eschbach-Zandbergen, Daphne Roos, Arjan van Tilburg, Ernst Jan, Spillenaar Bilgen, Nikki Knijn, Marnix A. J. de Roos, Ilse van Dop, Tracy Fitzsimmons, Hidde M. Kroon, Michael Penniment, Mitchell Raeside, Tarik Sammour, Steven J. Oosterling, Jeroen A. W. Tielbeek, Ronald J. C. L. M. Vuylsteke, Erik J. R. J. van der Hoeven, Anke B. Smits, Anniek H. Boer, Edgar J. B. Furnée, Robbert J. de Haas, Manon N. G. J. A. Braat, Wilhelmina M. U. van Grevenstein, Milan C. Richir, Patricia J. A. M. Brouwers, Tilly Leseman, Eric H. J. Belgers, Jasenko Krdzalic, Roy F. A. Vliegen

Publikováno v: BMJ Open, Vol 14, Iss 10 (2024)

Introduction Inadequate treatment of enlarged lateral lymph nodes (LLNs) in rectal cancer patients is associated with an increased lateral local recurrence (LLR) risk, despite neoadjuvant treatment and total mesorectal excision (TME) surgery. There i

Externí odkaz: https://doaj.org/article/340de40a283a4148be1229eb0c6c7cba