Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Marc Prentki"'
Autor:
Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Côté, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S.R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrol
Externí odkaz:
https://doaj.org/article/79bea110421e4fefa73fb7ee3e0d54e0
Autor:
Elite Possik, Clémence Schmitt, Anfal Al-Mass, Ying Bai, Laurence Côté, Johanne Morin, Heidi Erb, Abel Oppong, Wahab Kahloan, J. Alex Parker, S. R. Murthy Madiraju, Marc Prentki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Glycerol-3-phosphate phosphatase is a recently discovered enzyme at the heart of metabolism. Here, the authors used C. elegans and showed that its activation promotes stress resistance, healthy aging and acts as a calorie restriction mimetic at norma
Externí odkaz:
https://doaj.org/article/7ec50e33ccdf4e78a7f7c66bddf1bd95
Autor:
Anfal Al-Mass, Pegah Poursharifi, Marie-Line Peyot, Roxane Lussier, Isabelle Chenier, Yat Hei Leung, Anindya Ghosh, Abel Oppong, Elite Possik, Yves Mugabo, Rasheed Ahmad, Robert Sladek, S.R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101609- (2022)
Objective: Glycerol-3-phosphate (Gro3P) phosphatase (G3PP) hydrolyzes Gro3P to glycerol that exits the cell, thereby operating a “glycerol shunt”, a metabolic pathway that we identified recently in mammalian cells. We have investigated the role o
Externí odkaz:
https://doaj.org/article/ef4e4aa106094673b2a836cb280c8599
Autor:
Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Sophia M Sdao, Shih Ming Huang, Sophie L Lewandowski, Halena R VanDeusen, Shawn M Davidson, Rebecca L Cardone, Marc Prentki, Richard G Kibbey, Matthew J Merrins
Publikováno v:
eLife, Vol 11 (2022)
Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondrial PEP c
Externí odkaz:
https://doaj.org/article/fa152f2fa3f04b6c9965e3c25ec9218f
Autor:
Anfal Al-Mass, Pegah Poursharifi, Marie-Line Peyot, Roxane Lussier, Emily J. Levens, Julian Guida, Yves Mugabo, Elite Possik, Rasheed Ahmad, Fahd Al-Mulla, Robert Sladek, S.R.Murthy Madiraju, Marc Prentki
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101471- (2022)
Objective: The recently identified glycerol-3-phosphate (Gro3P) phosphatase (G3PP) in mammalian cells, encoded by the PGP gene, was shown to regulate glucose, lipid and energy metabolism by hydrolyzing Gro3P and to control glucose-stimulated insulin
Externí odkaz:
https://doaj.org/article/a0ad8776085242cfa158276b9c6297e7
Autor:
Elite Possik, Anfal Al-Mass, Marie-Line Peyot, Rasheed Ahmad, Fahd Al-Mulla, S. R. Murthy Madiraju, Marc Prentki
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Cardiometabolic diseases, including type 2 diabetes, obesity and non-alcoholic fatty liver disease, have enormous impact on modern societies worldwide. Excess nutritional burden and nutri-stress together with sedentary lifestyles lead to these diseas
Externí odkaz:
https://doaj.org/article/3976edef258f41cfaceb22b4353f8d6e
Autor:
Pegah Poursharifi, Camille Attané, Yves Mugabo, Anfal Al-Mass, Anindya Ghosh, Clémence Schmitt, Shangang Zhao, Julian Guida, Roxane Lussier, Heidi Erb, Isabelle Chenier, Marie-Line Peyot, Erik Joly, Christophe Noll, André C. Carpentier, S.R. Murthy Madiraju, Marc Prentki
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Enhanced energy expenditure in brown (BAT) and white adipose tissues (WAT) can be therapeutic against metabolic diseases. We examined the thermogenic role of adipose α/β-hydrolase domain 6 (ABHD6), which hydrolyzes monoacylglycerol (MAG), by employ
Externí odkaz:
https://doaj.org/article/e11e5cce8e0b4e328113e9c46cedfd1c
Autor:
Anna Motterle, Sonia Gattesco, Marie-Line Peyot, Jonathan Lou S. Esguerra, Ana Gomez-Ruiz, D. Ross Laybutt, Patrick Gilon, Frédéric Burdet, Mark Ibberson, Lena Eliasson, Marc Prentki, Romano Regazzi
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1407-1418 (2017)
Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes dev
Externí odkaz:
https://doaj.org/article/3b8e45242e6146db91dafa93326fa629
Autor:
Alexandre Fisette, Stephanie Tobin, Léa Décarie-Spain, Khalil Bouyakdan, Marie-Line Peyot, S.R. Murthy Madiraju, Marc Prentki, Stephanie Fulton, Thierry Alquier
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1217-1226 (2016)
Summary: α/β-Hydrolase domain 6 (ABHD6) is a monoacylglycerol hydrolase that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG). Although complete or peripheral ABHD6 loss of function is protective against diet-induced obesity and insulin r
Externí odkaz:
https://doaj.org/article/38c0435357f247599bf5d59aad540d0a
Autor:
Shangang Zhao, Yves Mugabo, Gwynne Ballentine, Camille Attane, Jose Iglesias, Pegah Poursharifi, Dongwei Zhang, Thuy Anne Nguyen, Heidi Erb, Raphael Prentki, Marie-Line Peyot, Erik Joly, Stephanie Tobin, Stephanie Fulton, J. Mark Brown, S.R. Murthy Madiraju, Marc Prentki
Publikováno v:
Cell Reports, Vol 14, Iss 12, Pp 2872-2888 (2016)
Suppression of α/β-domain hydrolase-6 (ABHD6), a monoacylglycerol (MAG) hydrolase, promotes glucose-stimulated insulin secretion by pancreatic β cells. We report here that high-fat-diet-fed ABHD6-KO mice show modestly reduced food intake, decrease
Externí odkaz:
https://doaj.org/article/84a1d24e99c3458a8ee984390c17eca2