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Akademický článek

Protection against retrovirus pathogenesis by SR protein inhibitors.

Autor: Anne Keriel, Florence Mahuteau-Betzer, Chantal Jacquet, Marc Plays, David Grierson, Marc Sitbon, Jamal Tazi

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4533 (2009)

Indole derivatives compounds (IDC) are a new class of splicing inhibitors that have a selective action on exonic splicing enhancers (ESE)-dependent activity of individual serine-arginine-rich (SR) proteins. Some of these molecules have been shown to

Externí odkaz: https://doaj.org/article/0a57b7cf303048918271a83cfbad7407

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Impaired anti-leukemic immune response in PKCθ-deficient mice

Autor: Chantal Jacquet, Martin Villalba, Sandra Kaminski, Johan Garaude, Fernando Rodriguez, Robert A. Hipskind, Javier Hernandez, Alberto Anel, Seyma Charni, Juan Ignacio Aguilo, Marc Plays

Publikováno v: Molecular Immunology. 45:3463-3469

The cancer immunosurveillance hypothesis has found strong experimental support in recent years. It is believed that cytotoxic lymphocytes are important effectors in this process. PKCtheta plays an essential role in proliferation, activation and survi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e42edc1c8a8b75a74817c22f36678d5
https://doi.org/10.1016/j.molimm.2008.03.016

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Efficient Mother-to-Child Transfer of Antiretroviral Immunity in the Context of Preclinical Monoclonal Antibody-Based Immunotherapy

Autor: Marc Plays, Laurent Gros, Mireia Pelegrin, Marc Piechaczyk

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2006, 80 (20), pp.10191--200. ⟨10.1128/JVI.01095-06⟩

When mice under the age of 5 to 6 days are infected, the FrCas E retrovirus induces a neurodegenerative disease leading to death within 1 to 2 months. We have recently reported that transient treatment with a neutralizing monoclonal antibody (MAb) sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf1d55e9738c1b4453127844b36928f
https://doi.org/10.1128/jvi.01095-06

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Induction of Long-Term Protective Antiviral Endogenous Immune Response by Short Neutralizing Monoclonal Antibody Treatment

Autor: Marc Plays, Hanna Dreja, Marc Piechaczyk, Mireia Pelegrin, Laurent Gros, Anne Laure Fiser

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2005, 79 (10), pp.6272--80. ⟨10.1128/JVI.79.10.6272-6280.2005⟩

Long-term immune control of viral replication still remains a major challenge in retroviral diseases. Several monoclonal antibodies (MAbs) have already shown antiviral activities in vivo, including in the clinic but their effects on the immune system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c56a51d76154e815a0318a8311b8bbb
https://doi.org/10.1128/jvi.79.10.6272-6280.2005

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Control of regulatory T cells is necessary for vaccine-like effects of antiviral immunotherapy by monoclonal antibodies

Autor: Mireia Pelegrin, Marc Piechaczyk, Marc Plays, Roudaina Nasser, Laurent Gros

Publikováno v: Blood
Blood, American Society of Hematology, 2013, 121 (7), pp.1102--11. ⟨10.1182/blood-2012-06-432153⟩

Regulatory T cells (Tregs) down-regulate immunity and are associated with chronic viral infections, suggesting that their inhibition might be used to treat life-threatening diseases. Using the FrCasE mouse retroviral model, we have recently shown tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dba24a90e2ae086f8f51191d7b76ce
https://hal.archives-ouvertes.fr/hal-02193666

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Long-lasting protective antiviral immunity induced by passive immunotherapies requires both neutralizing and effector functions of the administered monoclonal antibody

Autor: Henri-Alexandre Michaud, Mireia Pelegrin, Marc Plays, Laurent Gros, Marc Piechaczyk, Roudaina Nasser

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2010, 84 (19), pp.10169--81. ⟨10.1128/JVI.00568-10⟩

Using FrCasEretrovirus-infected newborn mice as a model system, we have shown recently that a long-lasting antiviral immune response essential for healthy survival emerges after a short treatment with a neutralizing (667) IgG2a isotype monoclonal ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e1cad11c12b2dc0797d21fd363c3be
https://hal.archives-ouvertes.fr/hal-02193587

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Protection against Retrovirus Pathogenesis by SR Protein Inhibitors

Autor: Marc Plays, David S. Grierson, Marc Sitbon, Jamal Tazi, Anne Keriel, Florence Mahuteau-Betzer, Chantal Jacquet

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2009, 4 (2), pp.e4533. ⟨10.1371/journal.pone.0004533⟩
PLoS ONE, Public Library of Science, 2009, 4 (2), pp.e4533. 〈10.1371/journal.pone.0004533〉
PLoS ONE, Vol 4, Iss 2, p e4533 (2009)

International audience; Indole derivatives compounds (IDC) are a new class of splicing inhibitors that have a selective action on exonic splicing enhancers (ESE)-dependent activity of individual serine-arginine-rich (SR) proteins. Some of these molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317b0add5d95e077b956bdafe470b521
https://doi.org/10.1371/journal.pone.0004533

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