Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Marc Piechaczyk"'
Autor:
Fabienne Bejjani, Emilie Evanno, Samantha Mahfoud, Claire Tolza, Kazem Zibara, Marc Piechaczyk, Isabelle Jariel-Encontre
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Background How transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers contacting the same gene promoter. In particular, it is not known whether they exert similar or
Externí odkaz:
https://doaj.org/article/b25711bde2a94d41951a8285f1786eab
Autor:
Beatriz Pérez-Benavente, Alihamze Fathinajafabadi, Lorena de la Fuente, Carolina Gandía, Arantxa Martínez-Férriz, José Miguel Pardo-Sánchez, Lara Milián, Ana Conesa, Octavio A. Romero, Julián Carretero, Rune Matthiesen, Isabelle Jariel-Encontre, Marc Piechaczyk, Rosa Farràs
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-35 (2022)
Abstract Background JUNB transcription factor contributes to the formation of the ubiquitous transcriptional complex AP-1 involved in the control of many physiological and disease-associated functions. The roles of JUNB in the control of cell divisio
Externí odkaz:
https://doaj.org/article/3a282b43f3554e168179534676a0acdc
Autor:
Ludovic Gabellier, Marion De Toledo, Mehuli Chakraborty, Dana Akl, Rawan Hallal, Mays Aqrouq, Giovanni Buonocore, Clara Recasens-Zorzo, Guillaume Cartron, Abigaïl Delort, Marc Piechaczyk, Denis Tempé, Guillaume Bossis
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
Acute myeloid leukemias (AML) are severe hematomalignancies with dismal prognosis. The post-translational modification SUMOylation plays key roles in leukemogenesis and AML response to therapies. Here, we show that TAK-981 (subasumstat), a first-in-c
Externí odkaz:
https://doaj.org/article/b6bdcf71115d4bb8be8915ca3cbc1c90
Autor:
Rosa Paolillo, Mathias Boulanger, Pierre Gâtel, Ludovic Gabellier, Marion De Toledo, Denis Tempé, Rawan Hallal, Dana Akl, Jérôme Moreaux, Hayeon Baik, Elise Gueret, Christian Recher, Jean-Emmanuel Sarry, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis
Publikováno v:
Haematologica, Vol 107, Iss 11 (2022)
Resistance to chemotherapeutic drugs is a major cause of treatment failure in acute myeloid leukemias (AML). To better characterize the mechanisms of chemoresistance, we first identified genes whose expression is dysregulated in AML cells resistant t
Externí odkaz:
https://doaj.org/article/693f4bfe8c834a5588ccd2b699cb8b45
Publikováno v:
Molecules, Vol 26, Iss 4, p 828 (2021)
One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is transcriptional control. This occurs via modification of virtually all classes of transcriptional actors, which include transcription factors, transcriptional c
Externí odkaz:
https://doaj.org/article/3457913ab9e0425187381873422fdf6a
Publikováno v:
Emerging Microbes and Infections, Vol 5, Iss 1, Pp 1-9 (2016)
Monoclonal antibodies (mAbs), which currently constitute the main class of biotherapeutics, are now recognized as major medical tools that are increasingly being considered to fight severe viral infections. Indeed, the number of antiviral mAbs develo
Externí odkaz:
https://doaj.org/article/a5b010bb8e8341618a0a0839d51432ad
Autor:
Guillaume Bossis, Jean-Emmanuel Sarry, Chamseddine Kifagi, Marko Ristic, Estelle Saland, François Vergez, Tamara Salem, Héléna Boutzen, Hayeon Baik, Frédérique Brockly, Mireia Pelegrin, Tony Kaoma, Laurent Vallar, Christian Récher, Stéphane Manenti, Marc Piechaczyk
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1815-1823 (2014)
Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought to induce cancer cell death through the generation of DNA double-strand breaks. Here, we report that one of their early effects is the loss of conjugation of t
Externí odkaz:
https://doaj.org/article/a065602d2f4f4979b6b770c84daff8bc
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 3895 (2019)
SUMO (Small Ubiquitin-related MOdifier) is a post-translational modifier of the ubiquitin family controlling the function and fate of thousands of proteins. SUMOylation is deregulated in various hematological malignancies, where it participates in bo
Externí odkaz:
https://doaj.org/article/f269bc2941ff4c5fa5b92f2ec4ca8fc1
Autor:
Henri-Alexandre Michaud, Tiphanie Gomard, Laurent Gros, Kevin Thiolon, Roudaina Nasser, Chantal Jacquet, Javier Hernandez, Marc Piechaczyk, Mireia Pelegrin
Publikováno v:
PLoS Pathogens, Vol 6, Iss 6, p e1000948 (2010)
Antiviral monoclonal antibodies (mAbs) represent promising therapeutics. However, most mAbs-based immunotherapies conducted so far have only considered the blunting of viral propagation and not other possible therapeutic effects independent of virus
Externí odkaz:
https://doaj.org/article/81054ed7d4bc41e5898a6c797b3603e3
Autor:
Tiphanie Gomard, Henri-Alexandre Michaud, Denis Tempé, Kevin Thiolon, Mireia Pelegrin, Marc Piechaczyk
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9585 (2010)
BACKGROUND: Dendritic cells (DCs) play a key role in the induction of adaptive and memory immune responses. Upon encounter with pathogens, they undergo a complex maturation process and migrate toward lymphoid organs where they stimulate immune effect
Externí odkaz:
https://doaj.org/article/5e2eb5ed204840aeb9341ccebf3d1619