Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Marc Pfister"'
Autor:
Tatjana Welzel, Klervi Golhen, Andrew Atkinson, Verena Gotta, David Ternant, Jasmin B. Kuemmerle-Deschner, Christine Michler, Gilbert Koch, Johannes N. van den Anker, Marc Pfister, Andreas Woerner
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background In pediatric rheumatic diseases (PRD), adalimumab is dosed using fixed weight-based bands irrespective of methotrexate co-treatment, disease activity (DA) or other factors that might influence adalimumab pharmacokinetics (PK). In
Externí odkaz:
https://doaj.org/article/f2c51365bcf44787aa48f649528e7736
Autor:
Klervi Golhen, Michael Buettcher, Jörg Huwyler, John van den Anker, Verena Gotta, Kim Dao, Laura E. Rothuizen, Kevin Kobylinski, Marc Pfister
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1186 (2024)
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB
Externí odkaz:
https://doaj.org/article/12e1f1321610492b84aa70d719982c48
Autor:
Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M. Posfay-Barbe, John van den Anker, Marc Pfister
Publikováno v:
Swiss Medical Weekly, Vol 154, Iss 4 (2024)
BACKGROUND AND AIMS: Pharmacometric in silico approaches are frequently applied to guide decisions concerning dosage regimes during the development of new medicines. We aimed to demonstrate how such pharmacometric modelling and simulation can provide
Externí odkaz:
https://doaj.org/article/1e2536a16ca447fea78a789062ead18b
Autor:
Alexander Marx, Francesco Di Stefano, Heike Leutheuser, Kieran Chin-Cheong, Marc Pfister, Marie-Anne Burckhardt, Sara Bachmann, Julia E. Vogt
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundThe overarching goal of blood glucose forecasting is to assist individuals with type 1 diabetes (T1D) in avoiding hyper- or hypoglycemic conditions. While deep learning approaches have shown promising results for blood glucose forecasting i
Externí odkaz:
https://doaj.org/article/ee19f3ed8022461f862ecbc15de208f0
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 207-220 (2023)
Abstract Diabetic ketoacidosis (DKA), a frequent complication of type 1 diabetes (T1D), is characterized by hyperosmolar hypovolemia. The response of water‐regulating hormones arginine vasopressin (AVP; antidiuretic hormone) and aldosterone to DKA
Externí odkaz:
https://doaj.org/article/99c58f0f7700484d8b4fa19c3d811bb6
Autor:
Marion Anliker‐Ort, Chih‐hsuan Hsin, Andreas Krause, Marc Pfister, John van denAnker, Jasper Dingemanse, Priska Kaufmann
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract The novel oral complement factor 5a receptor 1 antagonist ACT‐1014‐6470 was well tolerated in single‐ and multiple‐ascending dose studies, including 24 h Holter electrocardiogram (ECG) recordings evaluating its cardiodynamics based o
Externí odkaz:
https://doaj.org/article/cdc8f1bde06c4137bec9135314155bb7
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 12, Pp 1638-1648 (2022)
Abstract Missing data create challenges in clinical research because they lead to loss of statistical power and potentially to biased results. Missing covariate data must be handled with suitable approaches to prepare datasets for pharmacometric anal
Externí odkaz:
https://doaj.org/article/41d2fb2990be42f0ad388eb4544e9aab
Autor:
Tatjana Welzel, Lea Oefelein, Marinka Twilt, Marc Pfister, Jasmin B. Kuemmerle-Deschner, Susanne M. Benseler
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background Biological treatment and treat-to-target approaches guide the achievement of inactive disease and clinical remission in Autoinflammatory Diseases (AID). However, there is limited evidence addressing optimal tapering strategies and
Externí odkaz:
https://doaj.org/article/6ef6b005ccaf4a5aba7fd1c169b0aead
Autor:
Britta Steffens, Gilbert Koch, Pascal Gächter, Fabien Claude, Verena Gotta, Freya Bachmann, Johannes Schropp, Marco Janner, Dagmar l'Allemand, Daniel Konrad, Tatjana Welzel, Gabor Szinnai, Marc Pfister
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
ObjectivesGraves' disease (GD) with onset in childhood or adolescence is a rare disease (ORPHA:525731). Current pharmacotherapeutic approaches use antithyroid drugs, such as carbimazole, as monotherapy or in combination with thyroxine hormone substit
Externí odkaz:
https://doaj.org/article/c3e9c3811567474e91030811eae525aa
Autor:
Julia Deichmann, Sara Bachmann, Marie-Anne Burckhardt, Marc Pfister, Gabor Szinnai, Hans-Michael Kaltenbach
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 2, p e1010289 (2023)
Accurate treatment adjustment to physical activity (PA) remains a challenging problem in type 1 diabetes (T1D) management. Exercise-driven effects on glucose metabolism depend strongly on duration and intensity of the activity, and are highly variabl
Externí odkaz:
https://doaj.org/article/3e2656e76b3c42d69a2b2e1d486ccdf4