Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marc Pesant"'
Autor:
Marc Pesant, Christian Brochu, Rebekah J. Carson, Bruno Simoneau, Patricia Schroeder, Murray D. Bailey, Pierre R. Bonneau, Michael G. Cordingley, Catherine Chabot, Michel Garneau, Anne-Marie Faucher, Michael Bös, René Coulombe, Mathieu Parisien, Stephen W. Mason, Araz Jakalian, Jianmin Duan, Marc-André Poupart, Dominik Wernic, Sébastien Morin, François Bilodeau, Serge Landry, Yves Bousquet, Eric Malenfant, Stephen H. Kawai, Punit Bhardwaj, Ma’an Amad, Lee Fader, Youla S. Tsantrizos, Richard Bethell, Christiane Yoakim, Steven R. LaPlante, Paul J. Edwards, Ted Halmos, Craig Fenwick
Publikováno v:
ACS Medicinal Chemistry Letters. 5:422-427
An assay recapitulating the 3' processing activity of HIV-1 integrase (IN) was used to screen the Boehringer Ingelheim compound collection. Hit-to-lead and lead optimization beginning with compound 1 established the importance of the C3 and C4 substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bbe9a8b0f8d3640b1a6a0a1c772694
https://doi.org/10.1021/ml500002n
https://doi.org/10.1021/ml500002n
Autor:
Yongbo Hu, James Cutter, Naoki Asai, Taichi Abe, Hyeong-Wook Choi, Teiji Takigawa, Taiju Nakamura, Thomas Noland, Masanori Mizuno, Atsushi Endo, Marc Pesant, Michael D. Lewis, Takao Omae, Bryan M. Lewis, Kazuhiro Yoshizawa, Francis G. Fang, Tomohiro Watanabe, Shawn McKenna, William J. Christ, Naoki Ozeki, Brian Austad, Gordon D. Wilkie, Hirofumi Kuroda, Trevor Lee Calkins, Manabu Kubota, Akio Kayano, Yumi Asai, John D. Orr, Matthew J. Schnaderbeck, Farid Benayoud, Yuki Komatsu, Robert Costanzo, Silvio Campagna, Taeko Suzuki, Charles E. Chase, Yuichi Kimoto
Publikováno v:
Synlett. 24:327-332
Multikilogram manufacturing process of the Halaven® C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0b6f0e62a97eb1ab238ef7f2117e0
https://doi.org/10.1055/s-0032-1317920
https://doi.org/10.1055/s-0032-1317920
Autor:
Melissa J. MacDonald, Andre M. Beauchemin, Marc Pesant, Shu-Bin Zhao, Colin R. Hesp, Didier A. Bilodeau, M. Mehdi Zahedi
Publikováno v:
Organic letters. 17(20)
Catalysts possessing sufficient activity to achieve intermolecular alkene hydroaminations under mild conditions are rare, and this likely accounts for the scarcity of asymmetric variants of this reaction. Herein, highly diastereoselective hydroaminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cc87394ed6846d4fa3ebe4858c4f98
https://pubmed.ncbi.nlm.nih.gov/26417922
https://pubmed.ncbi.nlm.nih.gov/26417922
Publikováno v:
Tetrahedron Letters. 46:923-926
A strategy is outlined which enables preparation of novel laulimalide analogues at C.8 and C.11. A representative analogue, 8-(S)-methoxy-11-desmethyl laulimalide, was synthesized via this route.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a75ac61d36a4a69a3cc0a4fbe1ada79
https://doi.org/10.1016/j.tetlet.2004.12.056
https://doi.org/10.1016/j.tetlet.2004.12.056
Publikováno v:
Angewandte Chemie. 110:3454-3457
Die zeitliche Abfolge der π-Orbitalmischung bei der Diels-Alder-Cycloaddition von Butadien und Ethylen ist bei den beiden Hauptwechselwirkungen, namlich der HOMODien-LUMODienophil- und der HOMODienophil-LUMODien-Wechselwirkung, verschieden. Die C2-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d5968528cbcf5b9ce23bcb3a1ba7c22
https://doi.org/10.1002/(sici)1521-3757(19981204)110:23<3454::aid-ange3454>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19981204)110:23<3454::aid-ange3454>3.0.co
Autor:
Olivier Lepage, Martin Poirier, Christian Brochu, René Coulombe, Martin Marquis, Timothy A. Stammers, Oliver Hucke, Megan Bertrand-Laperle, George Kukolj, Marc Pesant, James Gillard, Serge Landry, Maude Poirier, Montse Llinas-Brunet, Marc-André Joly, Pierre L. Beaulieu, Pierre R. Bonneau, Ginette McKercher
Publikováno v:
Journal of medicinal chemistry. 57(5)
The design and preliminary SAR of a new series of 1H-quinazolin-4-one (QAZ) allosteric HCV NS5B thumb pocket 2 (TP-2) inhibitors was recently reported. To support optimization efforts, a molecular dynamics (MD) based modeling workflow was implemented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faeb18326199eafc018071f8d8bcdf3c
https://pubmed.ncbi.nlm.nih.gov/23773186
https://pubmed.ncbi.nlm.nih.gov/23773186
Publikováno v:
ChemInform. 44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732d71334d78edbfe76c9137fecf9bb6
https://doi.org/10.1002/chin.201327057
https://doi.org/10.1002/chin.201327057
Autor:
Léa Constantineau Forget, Cyrille Kuhn, Vida Gorys, Colette Boucher, Chantal Grand-Maître, Sylvain Bordeleau, Michael J. Little, Christian Brochu, Tim Guo, Marc Pesant, Michel Garneau, Megan Bertrand-Laperle, Catherine Spickler, Gulrez Fazal, Pascal Turcotte, Annick Gauthier, Eric Malenfant, Josée Bordeleau, Anne Decor, Jeff A. O'Meara, Ghiro Elise, Oliver Hucke
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(13)
We describe here the design, synthesis and biological evaluation of antiviral compounds acting against human rhinovirus (HRV). A series of aminothiazoles demonstrated pan-activity against the HRV genotypes screened and productive structure-activity r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e726058fc98e111b0fb3232d10f1f5ba
https://pubmed.ncbi.nlm.nih.gov/23726345
https://pubmed.ncbi.nlm.nih.gov/23726345
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 19(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3dff65015f5656e5526166c7859c4c4
https://pubmed.ncbi.nlm.nih.gov/23307591
https://pubmed.ncbi.nlm.nih.gov/23307591
Publikováno v:
Canadian Journal of Program Evaluation. 9:69-96
Abstract: Economic models of institutional analysis demonstrate that structural reforms exert very limited impacts on services and that margins for maneuver of policy instruments concerning financial and regulatory interventions are very narrow. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33b589f18da2e56308858f09b38994e
https://doi.org/10.3138/cjpe.09.005
https://doi.org/10.3138/cjpe.09.005