Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marc P.M. Soutar"'
Autor:
Christin Luft, Marc P.M. Soutar, Robin Ketteler, Marthe H.R. Ludtmann, Emily Annuario, Helene Plun-Favreau, Liam Kempthorne, Selina Wray
Publikováno v:
Autophagy
Mitochondrial quality control is essential for maintaining a healthy population of mitochondria. Two proteins associated with Parkinson disease, the kinase PINK1 and the E3 ubiquitin ligase PRKN, play a central role in the selective degradation of he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fc96e5f36512a1ea3908ce6432e531
https://doi.org/10.1080/15548627.2019.1603549
https://doi.org/10.1080/15548627.2019.1603549
Autor:
Helene Plun-Favreau, Daniela Melandri, Charles Arber, Jonathan D. Rohrer, Christopher J. Holler, Thomas Kukar, Marc P.M. Soutar, Adrian M. Isaacs, Selina Wray, Jackie M. Casey
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6af360f23f12b0193f1cb2de04da432
https://doi.org/10.1002/alz.042104
https://doi.org/10.1002/alz.042104
Autor:
Bictash M, AB Singleton, Helene Plun-Favreau, Nicholas W. Wood, David Zhang, Monaghan Ae, Paul Whiting, Claudia Manzoni, Alan M. Pittman, Welsh Nj, Ryten M, Guelfi S, Mark R. Cookson, John Hardy, Benjamin O’Callaghan, Annuario E, Danyah Trabzuni, Patrick A. Lewis, Alexander J. Whitworth, Marc P.M. Soutar, Cornelis Blauwendraat, Sonia Gandhi, Demis A. Kia, Daniela Melandri, Pan Ks, Henry Houlden, D’Sa K
Parkinson’s disease (PD) is a common incurable neurodegenerative disease. The identification of genetic variants via genome-wide association studies (GWAS) has considerably advanced our understanding of the PD genetic risk. Understanding the functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a586a41c3816d5f348ac92485873c54
Autor:
Marc P.M. Soutar, E. I. Fedotova, Helene Plun-Favreau, A. V. Berezhnov, Andrey Y. Abramov, Valeriy P. Zinchenko, Maria S. Frolova
Publikováno v:
Journal of Biological Chemistry. 291:8701-8708
The specific autophagic elimination of mitochondria (mitophagy) plays the role of quality control for this organelle. Deregulation of mitophagy leads to an increased number of damaged mitochondria and triggers cell death. The deterioration of mitopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dd185e9ba50dcd5fdc0400081af9dd
https://doi.org/10.1074/jbc.m115.691774
https://doi.org/10.1074/jbc.m115.691774
Autor:
Marc P.M. Soutar, Sybille Dihanich, Rosella Abeti, Helene Plun-Favreau, Rina Bandopadhyay, Paola Giunti, Sharon A. Tooze, Adamantios Mamais, Patrick A. Lewis, Claudia Manzoni
Publikováno v:
Biochimica et Biophysica Acta
Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most important genetic contributors to Parkinson's disease. LRRK2 has been implicated in a number of cellular processes, including macroautophagy. To test whether LRRK2 has a role in regulating autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c281270ed6bf50e54b0e3353f73c3361
Autor:
Jennifer E. Gallagher, Rory J. McCrimmon, Marc P.M. Soutar, David L. Hamilton, Selma Dadak, Elizabeth Haythorne, Karen A Wright, Craig Beall, Fiona B. Ashford, Lisa Logie, Michael L.J. Ashford, Qingyou Du, Aleksandar Jovanović
Publikováno v:
Diabetologia
Aims/hypothesis Hypothalamic glucose-excited (GE) neurons contribute to whole-body glucose homeostasis and participate in the detection of hypoglycaemia. This system appears defective in type 1 diabetes, in which hypoglycaemia commonly occurs. Unfort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4e7bb62d5c19f5cc5de91b6adb5712
https://doi.org/10.1007/s00125-012-2617-y
https://doi.org/10.1007/s00125-012-2617-y
Autor:
Ritchie Williamson, Marc P.M. Soutar, Calum Sutherland, Mark Peggie, Woo Yang Kim, Hilary McLauchlan, William D. Snider, Charles James Hastie, Phillip R. Gordon-Weeks
Publikováno v:
Journal of Neurochemistry. 115:974-983
Mammalian glycogen synthase kinase-3 (GSK3) is generated from two genes, GSK3α and GSK3β, while a splice variant of GSK3β (GSK3β2), containing a 13 amino acid insert, is enriched in neurons. GSK3α and GSK3β deletions generate distinct phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4738ab515bc3eae652a0db98aca23cb8
https://doi.org/10.1111/j.1471-4159.2010.06988.x
https://doi.org/10.1111/j.1471-4159.2010.06988.x
Publikováno v:
ResearcherID
Collapsin response mediator protein-2 (CRMP2) was recently identified as a physiological substrate for GSK3 and Cdk5, two protein kinases suggested to exhibit greater activity in Alzheimer's disease (AD). Indeed, phosphorylation of CRMP2, at the resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43211221e5ac3137a094d3ef32de9a88
https://doi.org/10.2174/156720509788486572
https://doi.org/10.2174/156720509788486572
Autor:
Marc P.M. Soutar, Martin Balastik, Lidy van Aalten, Adam R. Cole, Makoto Rembutsu, Hilary McLauchlan, C. James Hastie, Mark Peggie, Calum Sutherland, Kun Ping Lu
Publikováno v:
Journal of Biological Chemistry. 283:18227-18237
Collapsin response mediator protein 2 (CRMP2) binds to microtubules and regulates axon outgrowth in neurons. This action is regulated by sequential phosphorylation by the kinases cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdec9470677e6a59ebb8c3e4177c16bf
https://doi.org/10.1074/jbc.m801645200
https://doi.org/10.1074/jbc.m801645200
Autor:
Farid Rahimi, Daniela Ponce, Magda N. Haase, Maria V. Gianelli, Giancarlo Rossi, Gal Bitan, Zdena Kristofikova, Catherine M. Roe, Susanne Aileen Funke, Jana Kenney, Paul Thornhill, Roland Brandt, Christian Tackenberg, Hyman M. Schipper, Giancarlo Pepeu, Georgios Anogianakis, Pavel Selinger, Martina Kutová, Vasileios Papaliagkas, Manuel Sarasa, Céline Souchay, Marc P.M. Soutar, Joan E. Haase, Felipe Salech, Calum Sutherland, Chris J. A. Moulin, Filip Spaniel, Ajay Gupta, Emerich Majer, Alfredo Raglio, Silvia Morante, Massimo Stefan, Adam R. Cole, Debomoy K. Lahiri, Gianfranco Liguri, Adnan Ghori, Walter A. Szarek, Pedro Pesini, Maria Grazia Giovannini, Vasileios Kimiskidis, Jana Mrzilkova, Petr Zach, Daniela Řípová, Dieter Willbold, Eva Birkmann, Maria I. Behrens, Yueh-Feng Y. Lu
Publikováno v:
Advances in Alzheimer's Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f91d92691f86c3e70dcb780022f141f1
https://doi.org/10.2174/97816080549541130101
https://doi.org/10.2174/97816080549541130101